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Anthocyanins and cardiovascular risk, the beneficial effect of red fruits21-10-2016

The Journal of Translational Medicine published a study of the University of Milan, that explores the protective role of anthocyanins, commonly found in red fruits, versus cardiovascular diseases.

The Journal of Translational Medicine published a study of the University of Milan, coordinated by Daniele Cusi, Laura Soldati, Cristina Barlassina and Maurizio Turiel within the Eu funded Athena Project (AnThocyanin and polyphenols bioactive for Health Enhancement through Nutritional Advancement), with the aim to explore the protective role of anthocyanins, commonly found in red fruits, versus cardiovascular diseases.

The nutrigenetic study, conducted on 443 healthy volunteers recruited in two healthcare centers in Milano (Italy), highlighted the protective role of genetic variants in PON1 towards cardiovascular risk under high polyphenols consumption. 

Volunteers underwent a rigorous clinical examination and demographic data, information on diet, lifestyle and personal medical history werecollected. A blood sample was also taken for biochemistry and genetic analysis.

Researchers investigated the interaction between 18 independent tagging SNPs in PON1 gene, traditionally linked to lipid profile and cardiovascular risk, and polyphenols intake on common biomarkers of cardiovascular risk (HDL, LDL, cholesterol, triglycerides and atherogenic index of plasma).

Protective genotypes in 4 independent polymorphisms were identified, that presented a significant association with increased HDL level under high anthocyanins intake.

The PON1 variants could represent novel biomarkers to stratify individuals who might benefit from targeted dietary recommendation for health promotion and strategies of preventive medicine.

The research project is ongoing for the investigation of further candidate genes.


For information
The University of Milan
Department of Health Sciences
Dr: Laura Soldati
laura.soldati@unimi.it