Anatomic Pathology

A.Y. 2019/2020
6
Max ECTS
76
Overall hours
SSD
MED/08
Language
Italian
Learning objectives
The course aims to provide students with the tools to learn the pathological basis of organ and apparatus diseases and to be able to integrate macroscopic changes, histological and cytological modifications and molecular alterations into the clinical picture. The course will also describe the main diagnostic procedures in surgical pathology, the professional tasks, responsibilities and fields of activity of the pathologist. Teaching approach will be strictly integrated with that applied in the pathology modules of the system disease courses.
Expected learning outcomes
At the end of the course, the student has to
· become acquainted with the most important diagnostic tools (exfoliative and aspirative cytology, histology, cytology, frozen section) and techniques (immunohistochemistry and molecular pathology) of the surgical pathology;
· be aware of the possible applications of such tools in preventive medicine (cytological and molecular screening), in clinical diagnostics and in the evaluation of prognostic and predictive parameters;
· be able to properly interpret and integrate in the clinic the information provided by the pathology report for an appropriate therapeutic decision-making process.
Course syllabus and organization

Linea: Policlinico

Responsible
Course syllabus
Pathology of the skin
Inflammatory disorders of the skin
Non-melanocytic tumors
Melanocytic tumors

Pathology of the breast
Inflammatory lesions
Pre-neoplastic lesions
Benign and malignant tumors

Pathology of the Central Nervous System
Cerebral Edema, Hydrocephalus, Trauma
Cerebrovascular Disease
Infections
Demyelinating Diseases
Neurodegenerative Diseases
Tumors

Pathology of the Urinary Tract and Male Genital System
Glomerular Diseases
Tubular and Interstitial Diseases
Vascular Diseases
Neoplasms of the Kidney
Ureters
Urinary Bladder
Testis and Epididymis
Prostate

Pathology of the head and neck
Tumors of the oral cavity
Tumors of the salivary glands


Pathology of the bone, joints and soft tissues tumors
Tumors of the bone
Tumors of the soft tissues


Pathology of the female genital tract
Pathology of the cervix
Pathology of the uterus
Functional Endometrial Disorders
Endometriosis and adenomyosis
Endometrial Hyperplasia
Tumors of the endometrium and myometrium
Pathology of the ovary
Non-neoplastic and functional
Cysts of the ovary
tumors of the ovary
Gestational and placental disorders

Pathology of the thymus and mediastinum

Transplantation pathology
Prerequisites for admission
To have attended lessons of Anatomic Pathology in the courses of SPA I and SPA II
Teaching methods
Lectures, journal club, professionalizing activities
Teaching Resources
Robbins and Cotran. PATHOLOGIC BASIS OF DISEASE (9th Edition)
Assessment methods and Criteria
Oral test
MED/08 - PATHOLOGY - University credits: 6
Informal teaching: 16 hours
Lessons: 60 hours
Shifts:
Gruppo 1
Professor: Fusco Nicola
Gruppo 2
Professor: Fusco Nicola
Gruppo 3
Professor: Fusco Nicola
Gruppo 4
Professor: Fusco Nicola
Gruppo 5
Professor: Croci Giorgio Alberto
Gruppo 6
Professor: Croci Giorgio Alberto

Linea: San Donato

Responsible
Course syllabus
PRINCIPAL PROCEDURES AND TECHNIQUES in PATHOLOGy - Cytological and histological examinations; frozen intraoperative examinations. Histological, histochemical, immunohistochemical and molecular biology techniques - Notess on mortuary police regulation and autopsy.
CARDIOVASCULAR PATHOLOGY - Arteriosclerosis. Pathological bases, macro- and microscopic evolutionary aspects and complications of myocardial infarction, heart attack and chronic ischemic heart disease.
RESPIRATORY PATHOLOGY - Alveolar and interstitial pneumonia. Pneumoconiosis. Lung granulomatous disease. Primary and post-primary tuberculosis. - Histological and cytological diagnosis of lung cancer, histological classification of lung cancers, tumor stages and evaluation of predictive parameters of response to systemic treatments - Pleural mesothelioma.
PATHOLOGY OF THE DIGESTIVE TRACT - Cancers of the salivary glands. Classification and morphology of precancerous lesions of the oral cavity, esophagus, stomach and intestine - Morphological bases and tumor stage of oral, esophageal, gastric and intestinal cancers - Definition and histological classification of the polyps of the large intestine - chronic and acute pancreatitis. Histological classification of exocrine and endocrine tumors of the pancreas - chronic blood stasis, chronic hepatitis, cirrhosis and primary liver cancers.
PATHOLOGY OF THE HEMATOPOIETIC AND LYMPHOID SYSTEMS - Differential diagnosis of lymphadenitis - Classifications of Hodgkin's and nonHodgkin's lymphomas. - Pathological stage of lymphomas, diagnostic role of bone marrow aspiration and biopsy
ENDOCRINE PATHOLOGY - morphological bases of thyroid nodules, histological classification and characteristics of thyroid cancers; validity and limitations of cytological diagnosis - morphological bases of differential diagnosis between hyperplasia, benign and malignant tumors in endocrine pathology
PATHOLOGY OF URINARY TRACT AND MALE GENITAL SYSTEM - Acute and chronic nephritis and glomerulonephritis. Morphological features of kidney failure. Histological classification, morphological characteristics, evolution and stage of kidney and bladder cancer. Benign hyperplasia and prostate cancer. Testicular cancers.
NEUROPATHOLOGY - Morphological features of increased intracranial pressure (anatomical and pathological bases of hydrocephalus) - Hetiogenesis, morphology and evolution of intracranial hemorrhages and cerebral infarction - Pathological bases of brain infectious diseases (meningitis, meningoencephalitis, encephalitis, abscesses) - Histological classification and diagnosis of intracranial tumors.
DERMATOPATOLOGY - Basocellular and squamocellular carcinomas - morphological characteristics of benign nevi, dysplastic nevi and melanomas. Minimum criteria for differential diagnosis - Histological classification and staging systems of melanomas.
PATHOLOGY OF BONE AND SOFT TISSUES - Classification and pathological characteristics of bonetumors (osteoma, osteochondroma, chondroma, osteosarcoma, chondrosarcoma, giant cell cancer and Ewing's tumor - Histogenesis, morphological criteria of benignity and malignancy, grading of soft tissue sarcomas.
BREAST PATHOLOGY - Differential diagnosis of breast lumps- Epidemiology, pathogenesis, evolution, histological classification and pathological prognostic factors of breast cancer - Diagnostic role of cytology by fine needle aspiration, needle biopsy and intraoperative examination. Predictive factors of response to different systemic treatments.
PATHOLOGY OF FEMALE GENITAL TRACT- Definition of CIN, dysplasia, koilocytosis, in situ carcinoma, micro-invasive and invasive cervical carcinoma - Role of HPV in cancer etiopathogenesis. Prevention and early diagnosis strategies for cervical cancer - hyperplasia and endometrial cancers. Uterine leiomyoma and leiomyosarcoma- Ovarian tumors -Pathology of pregnancy.
Prerequisites for admission
Human Anatomy, Physiology, General Pathology
Teaching methods
Frontal lessons supported by visual means. Professional training activities in the Department
Teaching Resources
V. Kumar, A.K. Abbas, N. Fausto, J.C. Aster: Robbins e Cotran - Le basi patologiche delle malattie.
Assessment methods and Criteria
Oral test
MED/08 - PATHOLOGY - University credits: 6
Informal teaching: 16 hours
Lessons: 60 hours

Linea: San Giuseppe

Responsible
Course syllabus
Pathology of the skin
Inflammatory disorders of the skin
Non-melanocytic tumors
Melanocytic tumors

Pathology of the breast
Inflammatory lesions
Pre-neoplastic lesions
Benign and malignant tumors

Pathology of the Central Nervous System
Cerebral Edema, Hydrocephalus, Trauma
Cerebrovascular Disease
Infections
Demyelinating Diseases
Neurodegenerative Diseases
Tumors

Pathology of the Urinary Tract and Male Genital System
Glomerular Diseases
Tubular and Interstitial Diseases
Vascular Diseases
Neoplasms of the Kidney
Ureters
Urinary Bladder
Testis and Epididymis
Prostate

Pathology of the head and neck
Tumors of the oral cavity
Tumors of the salivary glands


Pathology of the bone, joints and soft tissues tumors
Tumors of the bone
Tumors of the soft tissues


Pathology of the female genital tract
Pathology of the cervix
Pathology of the uterus
Functional Endometrial Disorders
Endometriosis and adenomyosis
Endometrial Hyperplasia
Tumors of the endometrium and myometrium
Pathology of the ovary
Non-neoplastic and functional
Cysts of the ovary
tumors of the ovary
Gestational and placental disorders

Pathology of the thymus and mediastinum
Prerequisites for admission
To have attended lessons of Anatomic Pathology in the courses of SPA I and SPA II .
Teaching methods
Lectures, professionalizing activities in the ward of Anatomic Pathology.
Teaching Resources
Robbins and Cotran. PATHOLOGIC BASIS OF DISEASE (9th Edition)
Assessment methods and Criteria
Oral test
MED/08 - PATHOLOGY - University credits: 6
Informal teaching: 16 hours
Lessons: 60 hours
Professor: Pelosi Giuseppe
Educational website(s)
Professor(s)
Reception:
By appointment
European Institute of Oncology (IEO)
Reception:
Monday 12.00-13.00
Interhospital Pathology Division, Science and Technology Park, Via Fantoli 16/15, 20138 Milano