The course aims to provide notions that allow the student to acquire the knowledge related to the main biochemical-molecular aspects that are the basis of the biotransformation processes of xenobiotics and of the related molecular mechanisms of biotransformation regulation.
Expected learning outcomes
At the end of the course, the student must be able to illustrate the main metabolic pathways of biotransformation, and to have developed a critical awareness that may be useful in reading and interpreting scientific articles that will be also objective of the final discussion.
Lesson period: First semester
(In case of multiple editions, please check the period, as it may vary)
The liver: structure, metabolic functions, detoxifying function, liver damage and biochemical markers of liver function. Xenobiotics: Phase I, II, III Biotransformation Reactions. Cytochromes P450 (CYP), classification, polymorphisms and drug-metabolic induction. Transcription and regulation of gene transcription in eukaryotes. Nuclear receptors: general characteristics and history. Nuclear receptors activated by xenobiotics: SXR, PXR, CAR, AHR and PPARs. Receptors for endogenous molecules and endocrine disruptors
Prerequisites for admission
Knowledge of general biochemistry and human anatomy and physiology
Lectures and analysis of the literature relating to one or more nuclear receptors