System diseases 2

A.Y. 2019/2020
12
Max ECTS
144
Overall hours
SSD
BIO/12 MED/07 MED/08 MED/10 MED/15 MED/36
Language
English
Learning objectives
The System Diseases 2 course takes the students into clinical medicine with the study of the "Blood Diseases" (Hematology) and the "Diseases of the Respiratory System" (Pneumology). Such studies will be dealt on a comprehensive basis, i.e. including Diagnostic Imaging, Pathology, Clinical Biochemistry and Microbiology, in relation to the diseases of the organ.
The students will aquire knowledge on:
-the basic concept of laboratory test which will be integrated with new methodologies to be translated in the near future in clinical laboratory: clinical enzymology, methodologies utilized to monitor proteins, antibodies and RNA messengers.
-basic concepts related to new and high throughput technologies applied to biological fluids for markers monitoring.
-the most important aspect of respiratory medicine, examining prevalence, risk factors, pathophysiological and clinical aspect of the most important lung diseases.
- the analysis of the most relevant respiratory disease entities from pathogenesis to clinical features to diagnostic approach and principles of treatment.
- the respiratory diseases during differential diagnosis in routine clinical practice, and perform/interpret the correct laboratory tests to exclude/confirm the diagnosis and for clinical management.
-the most relevant hematological disease entities from pathogenesis to clinical features to diagnostic approach and principles of treatment.
-the relevance of infectious diseases on the pathogenesis of hematological malignancies and during the various stages of cancer treatment
- the imaging techniques and interpretation of radiologic studies.
- the pathogenetic mechanisms, morphologic changes, evolution and complications of obstructive, restrictive diseases of the lung together with pulmonary infections and neoplastic diseases of lung and pleura.
Expected learning outcomes
Students are expected to achieve general and specific requirements:
- report main diagnostics imaging modalities used to evaluate the respiratory system (X-ray, ultrasound, computed tomography [CT]).
- describe the normal anatomy on a chest radiograph, the normal anatomy on a chest CT and how and when to perform a contrast-enhanced or non-contrast CT and understand when ultrasound should be used in the lung.
-recognize the main abnormalities on a chest radiograph and the main abnormalities on a CT of the chest related to the main respiratory diseases
-describe pathogenetic mechanisms, morphologic changes, evolution and complications of respiratpry and hematologic diseases.
- recognize the pathogenesis, clinical features, diagnostic approach and principles of treatment of the most relevant respiratory disease entities.
- Report indications, technique and complications of image-guided pulmonary interventional procedures.
- Recognize the main features of imaging of thrombosis and pulmonary thromboembolism and related interventional procedures - intravascular thrombolysis, vena cava filters.
- describe the basic concept of laboratory test.
- describe the role of bone marrow biopsy in the diagnosis of myeloid neoplasms, their ontogenetic process and the updated classification
-recognize the pathogenesis, clinical features, diagnostic approach and principles of treatment of the most relevant hematologic disease entities.
Course syllabus and organization

Single session

Responsible
Prerequisites for admission
To take the System Diseases 2 exam, students must have already passed all the exams of the first and second year (Fundamentals of Basic Sciences, Cells, Molecules and Genes 1 and 2, Human Body, Functions and Mechanisms of Diseases).
Assessment methods and Criteria
Student assessment is based on a combination of written and oral examinations.
The written exam is a multiple choice test focused on the topics of the modules: Clinical Biochemistry, Microbiology, Pathology (10 questions for each subject). Only students who successfully pass the written tests of all subjects (threshold 7/10) are allowed to take the oral examination, focused on the modules: Diagnostic Imaging, Respiratory Diseases and Blood Diseases.
The oral examination must be passed in the same session as the written examination.
The students must undergo both written and oral examination on the same day. If the student does not pass successfully the oral examination, the positive result at the written test is valid only within the same session.
The final mark is the average of the marks obtained in the three oral examinations weighted for the number of credits of each discipline.
The exam is deemed to be passed successfully if the final grade is equal to or higher than 18/30. In the event of a full grade (30/30) honors (lode) may be granted with the consent of all the professors.
Registration to the exam through SIFA is mandatory.
Blood diseases
Course syllabus
CLINICAL BIOCHEMISTRY:
Lecture 1. Clinical Enzymology
Lecture 2. Diagnostic tools in clinical laboratory for disease onset and progression. Real Time PCR
Lecture 3. Diagnostic tools in clinical laboratory for disease onset and progression; test Elisa
Lecture 4. Plasma protein profile and high throughput technologies and
Lecture 5. Hypoxia adaptation: molecular mechanisms and monitoring
Lecture 6. Sarcopenia and cachexia: the relevance of muscle mass loss in metabolic disorder, cancer and aging.
RESIRATORY DISEASES:
Lecture 1. Pulmonary function tests and imaging
Lecture 2. Chronic Obstructive Pulmonary Disease - COPD
Lecture 3. Asthma
Lecture 4. Diffuse parenchymal lung diseases (DPLD)
Lecture 5. Obstructive and Restrictive lung diseases
Lecture 6. Respiratory infections, including pneumonia
Lecture 7. Respiratory diseases and microbial infection
Lecture 8. Tuberculosis (TB), Latent TB Infection (LTBI) and non-tuberculous mycobacteria (NTM)
Lecture 9. Bronchiectasis (Bx) and Cystic Fibrosis (CF)
Lecture 10. Sleep and Sleep disorders
Lecture 11. Pulmonary Vascular Diseases (PVDs)
Lecture 12. Thoracic Tumours (TT)
Lecture 13. Lung cancer
Lecture 14. Pathology of the pleura
Lecture 15. Pleural diseases
Lecture 16. Acute and chronic respiratory failure (RF)
Case studies
HEMATOLOGY:
Lecture 1. Introduction to the course
Lecture 2. Overview of hemostasis and thrombosis
Lecture 3. Bleeding syndromes
Lecture 4. Thrombotic disorders and thrombotic microangiopathies
Lecture 5. Imaging of thrombosis and pulmonary thromboembolism and related interventional procedures - intravascular thrombolysis, vena cava filters
Lecture 6. Principles of erythropoiesis and hypo-regenerative anemias
Lecture 7. Hemoglobinopathies, red cell enzymopathies and membrane disorders
Lecture 8. Hemolitic anemias and transfusional medicine
Lecture 9. Ph-negative and Ph+ myeloproliferative syndromes
Lecture 10. Acute myeloid and lymphoid leukemias
Lecture 11. Myelodysplastic and bone marrow failure syndromes
Lecture 12. Plasma cell disorders
Lecture 13. Microbes and hematologic diseases
Lecture 14 - Lymphoid neoplasms I part
Lecture 15 - Lymphoid neoplasms II part
Lecture 16. Clinical approach to lymphadenopathies and splenomegaly
Lecture 17. Hodgkin Lymphoma
Lecture 18. Non-Hodgkin lymphomas
Lecture 19. Chronic lymphoid leukemia
Lecture 20. Infections in the pathogenesis of hematological neoplasms
Lecture 21.PET in the staging and restaging of lymphomas
Lecture 22. Types and indications to bone marrow transplantation
Lecture 23. Infections in the immunocompromised host
Lecture 24. The role of bone marrow biopsy in the diagnosis of myeloid neoplasms
Lecture 25. Normal hemopoeisis and bone marrow microenvironment, including laboratory techniques in hematology
Lecture 26. From theory to practice
Lecture 27. From theory to practice: approach to hematological emergencies
Lecture 28. From theory to practice
Teaching methods
Lectures, Clinical cases, Case studies. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Teaching Resources
· Harrison's Principles of Internal Medicine, 20th Edition, McGraw Hill, 2018 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Robbins and Cotran. Pathologic Basis Of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Hematology Pathophysiology, Diagnosis and Treatment. Tura, Cavo, Zinzani. Società Editrice Esculapio 2018
· Teaching material from the individual lectures
· Website: www.uptodate.com
Respiratory diseases
Course syllabus
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Blood diseases.
Teaching methods
Lectures, Clinical cases, Case studies. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Teaching Resources
· Harrison's Principles of Internal Medicine, 20th Edition, McGraw Hill, 2018 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Robbins and Cotran. Pathologic Basis Of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Hematology Pathophysiology, Diagnosis and Treatment. Tura, Cavo, Zinzani. Società Editrice Esculapio 2018
· Teaching material from the individual lectures
· Website: www.uptodate.com
Pathology
Course syllabus
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Blood diseases.
Teaching methods
Lectures, Clinical cases, Case studies. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Teaching Resources
· Harrison's Principles of Internal Medicine, 20th Edition, McGraw Hill, 2018 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Robbins and Cotran. Pathologic Basis Of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Hematology Pathophysiology, Diagnosis and Treatment. Tura, Cavo, Zinzani. Società Editrice Esculapio 2018
· Teaching material from the individual lectures
· Website: www.uptodate.com
Radiology
Course syllabus
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Blood diseases.
Teaching methods
Lectures, Clinical cases, Case studies. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Teaching Resources
· Harrison's Principles of Internal Medicine, 20th Edition, McGraw Hill, 2018 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Robbins and Cotran. Pathologic Basis Of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Hematology Pathophysiology, Diagnosis and Treatment. Tura, Cavo, Zinzani. Società Editrice Esculapio 2018
· Teaching material from the individual lectures
· Website: www.uptodate.com
Microbiology
Course syllabus
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Blood diseases.
Teaching methods
Lectures, Clinical cases, Case studies. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Teaching Resources
· Harrison's Principles of Internal Medicine, 20th Edition, McGraw Hill, 2018 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Robbins and Cotran. Pathologic Basis Of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Hematology Pathophysiology, Diagnosis and Treatment. Tura, Cavo, Zinzani. Società Editrice Esculapio 2018
· Teaching material from the individual lectures
· Website: www.uptodate.com
Clinical biochemistry
Course syllabus
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Blood diseases.
Teaching methods
Lectures, Clinical cases, Case studies. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Teaching Resources
· Harrison's Principles of Internal Medicine, 20th Edition, McGraw Hill, 2018 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Robbins and Cotran. Pathologic Basis Of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Hematology Pathophysiology, Diagnosis and Treatment. Tura, Cavo, Zinzani. Società Editrice Esculapio 2018
· Teaching material from the individual lectures
· Website: www.uptodate.com
Blood diseases
MED/15 - BLOOD DISEASES - University credits: 4
Lessons: 48 hours
Clinical biochemistry
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 12 hours
Professor: Gelfi Cecilia
Microbiology
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 1
Lessons: 12 hours
Pathology
MED/08 - PATHOLOGY - University credits: 1
Lessons: 12 hours
Radiology
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 12 hours
Respiratory diseases
MED/10 - RESPIRATORY DISEASES - University credits: 4
Lessons: 48 hours
Educational website(s)
Professor(s)
Reception:
To be arranged by e-mail
Pad. Granelli, CTMO, Fondazione Ospedale Maggiore Policlinico, Milan
Reception:
Monday 12.00-13.00
Interhospital Pathology Division, Science and Technology Park, Via Fantoli 16/15, 20138 Milano
Reception:
Upon email contact
IRCCS Istituto Ortopedico Galeazzi, Radiology Unit, floor -2