System diseases 3

A.Y. 2019/2020
14
Max ECTS
168
Overall hours
SSD
BIO/12 MED/07 MED/08 MED/12 MED/13 MED/36
Language
English
Learning objectives
The course is designed to address, with systematic and multidisciplinary approach the diseased of endocrine and gastrointestinal systems. The endocrinology module is designed to teach the students the appropriate skills to diagnose patients with endocrine disorders, to interpret endocrine tests and manage acute and chronic conditions. The gastroenterology module addresses disorders and diseases of the Gastrointestinal Tract, including the Liver and the Pancreas with a systematic approach and is designed to make students familiar with clinical presentation and differential diagnosis of GI diseases.
Aside to Endocrine and Gastrointestinal module, there are (similarly to SD1 and SD2) the moduls of radiology and nuclear medicine modules, clinical biochemistry, microbiology and pathology modules. The imaging issues related to the clinical topics of endocrinology and gastroenterology, the clinical biochemistry module introduce the laboratory tests used to diagnose and monitor endocrine and gastrointestinal disorders, the role, the pathogenic mechanism and the laboratory methods available for rapid diagnosis of the gastrointestinal and endocrine diseases (including the liver) related etiology agents and the pathological features of neoplastic and non-neoplastic lesions of endocrine and gastrointestinal diseases will be addressed. The pathological changes of the liver and of the pancreas in the course of neoplastic, infectious and inflammatory diseases are addressed.
Expected learning outcomes
Students are expected to:
- identify the typical and atypical features of endocrine disorders, their presentation, clinical course and expected outcome. - interpret endocrine tests and manage acute and chronic conditions.
- describe aetiologies, pathogenetic mechanisms, morphological changes of neoplastic proliferations of the pituitary gland, thyroid gland, parathyroid glands and adrenal gland
- describe pathological classification and prognostic markers of the neuroendocrine tumors.
-describe aetiologies, pathogenetic mechanisms and morphological changes of non-neoplastic diseases of the endocrine system.
- interpret endocrine tests and manage acute and chronic conditions.
-identify the typical and atypical features of gastrointestinal disorders, their presentation, differential diagnosis, clinical course and expected outcome.
-describe aetiologies, pathogenetic mechanisms and morphological changes of non-neoplastic diseases of the gastrointestinal tract
-describe the aetiologies, pathogenetic mechanisms, morphological changes, prognostic and predictive factors of esophageal, gastric and intestinal tumors.
- describe the pathological changes of the liver in hepatitis and cirrhosis and tumors and tumor-like lesions.
-describe the pathological changes of the inflammatory and neoplastic conditions of the pancreas
- interpret the laboratory tests used to diagnose and monitor endocrine and gastrointestinal disorders.
-interpret the imaging issues related to the clinical topics of endocrinology and gastroenterology.
- describe the pathogenic mechanism and the laboratory methods for rapid diagnosis of the gastrointestinal and endocrine diseases related etiology agents.
Course syllabus and organization

Unique edition

Responsible
Prerequisites for admission
To take the System Diseases 3 exam, students must have already passed all the exams of the first and second year (Fundamentals of Basic Sciences, Cells, Molecules and Genes 1 and 2, Human Body, Functions and Mechanisms of Diseases).
Assessement methods and criteria
Student assessment is based on a combination of written and oral examinations.
The written exam is a multiple choice test focused on the topics of the modules: Clinical Biochemistry, Microbiology, Pathology (10 questions for each subject). Only students who successfully pass the written tests of all subjects (threshold 7/10) are allowed to take the oral examination, focused on the modules: Diagnostic Imaging, Endocrinology and Gastroenterology.
The oral examination must be passed in the same session as the written examination.
The students must undergo both written and oral examination on the same day. If the student does not pass successfully the oral examination, the positive result at the written test is valid only within the same session.
The final mark is the average of the marks obtained in the three oral examinations weighted for the number of credits of each discipline.
The exam is deemed to be passed successfully if the final grade is equal to or higher than 18/30. In the event of a full grade (30/30) honors (lode) may be granted with the consent of all the professors.
Registration to the exam through SIFA is mandatory.
Gastroenterology
Course syllabus
ENDOCRINOLOGY AND METABOLISM
Lecture 1 - Impact of endocrinology on general health
Lecture 2 - Hypothalamus and Pituitary
Lecture 3 - Hypothalamus and pituitary: hypopituitarism
Lecture 4 - Thyroid function and hypothyroidism
Lecture 5 - Thyroid dysfunction: hyperthyroidism
Lecture 6 - Diagnostic problems of thyroid conditions and rare thyroid diseases
Lecture 7 - Thyroid goiter, nodules and cancers
Lecture 8 - Obesity, disorders of lipid metabolism and nutrition disorders
Lecture 9 - Diabetes Mellitus type 1 and 2
Lecture 10 - Hypoglycemia and differential diagnosis
Lecture 11 - Diabesity and gouts
Lecture 12 - Urbanization, life style changes and metabolic diseases
Lecture 13 - Male reproductive endocrinology
Lecture 14 - Female reproductive endocrinology
Lecture 15 - Adrenal function and diseases
Lecture 16 - Discussion of clinical cases and adrenal imaging and Pathology
Lecture 17 - Disorders of calcium homeostatsis
Lecture 18 - Multiple Endocrine Neoplasia and neuroendocrine tumors
Lecture 19: Metabolic Bone disorders
Lecture 20 - Pathology of the Thyroid
Lecture 21 - Pathology of the pituitary gland and adrenal gland
Lecture 22 Neuroendocrine tumors
Lecture 22 - Pathogenic role of microbes in endocrine diseases - part 1
Lecture 23 - Pathogenic role of microbes in endocrine diseases - part 2
Interactive clinical case discussion
Interactive clinical case discussion

GASTROENTEROLOGY
Session 1. Course Presentation & Frontier Lecture
Session 2. System Diseases: Esophagus
Session 3. Approach to the patient with dysphagia and gastric symptoms
Session 4. Pathology of the esophagus
Session 5. System Diseases: Stomach and Duodenum
Session 6. Approach to Patients with GI bleeding
Session 7. Pathology of the stomach
Session 8. System Diseases: Pancreas
Session 9. Pathology of the pancreas
Session 10. Approach to the patient with Liver disease
Session 11. Liver diseases due to infectious Agents
Session 12. Clinical consequences of Liver diseases
Session 13. System Diseases: Immune mediated Liver diseases
Session 14. System Diseases: Inherited liver diseases
Session 15. Metabolic and toxic liver diseases
Session 16. Diseases of the biliary tract
Session 17 - Pathology of the liver
Session 18 System Diseases: Small and Large Intestine - Part 1
Session 19. Frontier Lecture/Seminar: Intestinal epithelium: a multifunctional machinery
Session 20. Approach to the patients with chronic diarrhea
Session 21. Uses and abuses of laboratory tests, with special reference to neoplastic markers
Session 22. System Diseases: Small and Large Intestine Part 2
Session 23. Non-neoplastic diseases of the small intestine and large bowel
Session 24. Tumours of the small and Large intestine
Session 25. Etiology, pathogenesis and laboratory diagnosis of viral diseases of gastrointestinal tract including the liver
Session 26. Etiology, pathogenesis and laboratory diagnosis of parasitic, fungine and bacterial diseases of gastrointestinal tract including the liver
Session 27 - Appendix and the anal canal
Session 28 - Molecular pathology of tumours of the gastrointestinal tract
Session 29. The pathology report in gastrointestinal pathology
Teaching methods
Lectures, Clinical cases, Seminars, Grand Rounds, Case studies and Laboratory skills. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Bibliography
· Harrison's Principles of Internal Medicine, 20th Edition, McGraw Hill, 2018 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Endotext: The best Clinical Endocrinology source in the world, and FREE. (www.endotext.org)
· Sleisenger And Fordtran's Gastrointestinal And Liver Disease, 10th edition
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Robbins and Cotran. Pathologic basis of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
Endocrinology
Course syllabus
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Gastroenterology
Teaching methods
Lectures, Clinical cases, Seminars, Grand Rounds, Case studies and Laboratory skills. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Bibliography
· Harrison's Principles of Internal Medicine, 20th Edition, McGraw Hill, 2018 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Endotext: The best Clinical Endocrinology source in the world, and FREE. (www.endotext.org)
· Sleisenger And Fordtran's Gastrointestinal And Liver Disease, 10th edition
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Robbins and Cotran. Pathologic basis of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
Pathology
Course syllabus
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Gastroenterology
Teaching methods
Lectures, Clinical cases, Seminars, Grand Rounds, Case studies and Laboratory skills. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Bibliography
· Harrison's Principles of Internal Medicine, 20th Edition, McGraw Hill, 2018 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Endotext: The best Clinical Endocrinology source in the world, and FREE. (www.endotext.org)
· Sleisenger And Fordtran's Gastrointestinal And Liver Disease, 10th edition
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Robbins and Cotran. Pathologic basis of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
Radiology
Course syllabus
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Gastroenterology
Teaching methods
Lectures, Clinical cases, Seminars, Grand Rounds, Case studies and Laboratory skills. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Bibliography
· Harrison's Principles of Internal Medicine, 20th Edition, McGraw Hill, 2018 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Endotext: The best Clinical Endocrinology source in the world, and FREE. (www.endotext.org)
· Sleisenger And Fordtran's Gastrointestinal And Liver Disease, 10th edition
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Robbins and Cotran. Pathologic basis of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
Microbiology
Course syllabus
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Gastroenterology
Teaching methods
Lectures, Clinical cases, Seminars, Grand Rounds, Case studies and Laboratory skills. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Bibliography
· Harrison's Principles of Internal Medicine, 20th Edition, McGraw Hill, 2018 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Endotext: The best Clinical Endocrinology source in the world, and FREE. (www.endotext.org)
· Sleisenger And Fordtran's Gastrointestinal And Liver Disease, 10th edition
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Robbins and Cotran. Pathologic basis of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
Clinical Biochemistry
Course syllabus
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Gastroenterology
Teaching methods
Lectures, Clinical cases, Seminars, Grand Rounds, Case studies and Laboratory skills. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Bibliography
· Harrison's Principles of Internal Medicine, 20th Edition, McGraw Hill, 2018 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Endotext: The best Clinical Endocrinology source in the world, and FREE. (www.endotext.org)
· Sleisenger And Fordtran's Gastrointestinal And Liver Disease, 10th edition
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Robbins and Cotran. Pathologic basis of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
Clinical Biochemistry
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 12 hours
Endocrinology
MED/13 - ENDOCRINOLOGY AND METABOLISM - University credits: 4
Lessons: 48 hours
Gastroenterology
MED/12 - GASTROENTEROLOGY - University credits: 4
Lessons: 48 hours
Microbiology
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 1
Lessons: 12 hours
Professor: Alteri Claudia
Pathology
MED/08 - PATHOLOGY - University credits: 2
Lessons: 24 hours
Radiology
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 2
Lessons: 24 hours
Educational website(s)
Professor(s)
Reception:
By appointment
European Institute of Oncology (IEO)
Reception:
Monday 12.00-13.00
Interhospital Pathology Division, Science and Technology Park, Via Fantoli 16/15, 20138 Milano
Reception:
Upon email contact
IRCCS Istituto Ortopedico Galeazzi, Radiology Unit, floor -2