The lectures and the individual laboratory training of Drug Analysis II and Laboratory of Drug Analysis II are aimed at providing the student with the knowledge and the practice of chemical and instrumental methods for the identification of the substances reported in European Pharmacopoeia monographs, improving his critical skills in approaching analytical challenges in the pharmaceutical field.
At the end of the course, the student will be able to understand the theoretical aspects of the principal techniques of identification and analysis of pharmaceutical substances and to properly apply them so as to answer the questions of the conclusive written examination.
Recognition of organic and metallorganic substances of pharmaceutical interest Introduction to the analysis of organic compounds. Organoleptic examination. Combustion tests and residue analysis, recognition of metals in organometallic substances registered in the F.U. Preparation of Lassaigne's solution for the detection of nitrogen, sulfur, halogens, phosphorus. Solubility of organic substances: solubility in water and reactive solvents; classification of substances based on their solubility. Assays for the recognition of functional groups in organic substances: alcohols, aldehydes, ketones, polyalcohols, sugars, carboxylic acids, α-oxyacids, phenols, amines, amino acids, esters, amides. Examination of the substances registered in the F.U. Pharmaceutical substance classes: general and specific tests for alkaloids, sulpha, xanthine, glycosides, various substances. Recognition of inorganic substances of pharmaceutical interest.