Medicinal Chemistry 1

A.Y. 2019/2020
Lesson for
10
Max ECTS
80
Overall hours
SSD
CHIM/08
Language
Italian
Learning objectives
The lectures are aimed at providing the student with background knowledge and understating
- of how drugs interacts with their biological targets
- of how drugs get to their targets (ADMET)
- of the main principles of drug design and development
- of the issues in drug design (SAR and QSAR)
- of some classes of drugs, such as antibacterial, antiprotozoal, antiviral and anticancer agents.
At the end of the course, the student is expected:
- to know the principles and the strategies applied in the rational drug design;
- to critically evaluate the chemico-physical properties and the structure-activity relationships for the considered classes of drugs
- to gain the theoretical bases to understand how the pharmacokinetic profile influences the activity of a given drug
- to reach lifelong learning skills involving a multifaceted knowledgebase on how the chemical properties impact on drug activity. These skills will be useful for further student's personal study and will allow a proper evaluation of the new drugs that will reach the market.

Course structure and Syllabus

Linea AL
Active edition
Yes
Responsible
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 10
Lessons: 80 hours
Professor: Pallavicini Marco
Lesson period
year
Linea MZ
Active edition
Yes
Responsible
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 10
Lessons: 80 hours
Professor: Vistoli Giulio
Syllabus
General topics
Introduction to the medicinal chemistry
The drug discovery e development process
The three phases of drug action
Pharmaceutical phase
Pharmacokinetic Phase
Drug metabolism and toxicity
Pharmacodynamic Phase: mechanism of action
Thermodynamics of ligand binding
Rational design of a new drug: basic principles
The role of conformational and configurational effects
The concept of isosterism and bioisosterism
Structure activity relationships
Quantitative Structure activity relationships (QSAR)
Molecular descriptors: focus on lipophilicity
Structure-based and ligand-based drug design

Systematic topics
Disinfectants and antiseptics
Synthetic antibacterial drugs
Antibiotics
Antimycobacterial drugs
Pesticides
Antimalarial drugs
Antiviral drugs
Anticancer drugs
Lesson period
year
Lesson period
year
Assessment methods
Esame
Assessment result
voto verbalizzato in trentesimi