Medicine and pharmacology

A.Y. 2016/2017
Lesson for
8
Max ECTS
120
Overall hours
SSD
BIO/14 MED/09
Language
Italian

Course structure and Syllabus

Sezione: Busto Arsizio
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Professor: Mainardi Giovanna
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: Bonoldi Guido
Sezione: Cernusco
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Professor: Nisoli Enzo
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: Sampietro Maurizio
Sezione: Crema
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: Pedrinazzi Claudio
Sezione: Don Gnocchi
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Professor: Canti Gianfranco
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: Vismara Alessandro
Sezione: Fatebenefratelli
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: Longo Lisa
Sezione: IEO
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Professor: Camera Marina
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: De Pas Tommaso Martino
Sezione: Istituto Tumori
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professors: Bossi Paolo, Guidetti Anna, Lucini Daniela
Sezione: Magenta
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: Faccendini Maria Ester
Sezione: Niguarda
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Professors: Ferruzzi Marcello, Lesma Elena Anna
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: Broccolino Marco Pier
Sezione: Policlinico
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: Froldi Marco
Farmacologia
Syllabus
Module program:
General Pharmacology
1. Definition of Pharmacology
2. Pharmacodynamics
- Drug Receptors
- Agonists (full, partial, inverse) and antagonists (competitive and noncompetitive)
- Drug-receptor interactions - affinity, intrinsic activity
- The dose-response relationship(s)
3. Pharmacokinetics
- Routes of administration of the drugs
- Absorption, distribution metabolism and elimination of the drugs.
- Plasma drug concentration as a function of time
- Dose-response relationships
- Efficacy, potency
- Long-term effects of drugs (including tolerance and regulation of gene expression)
4. Principles of Pharmacogenetics and Pharmacogenomics
5. Development, Evaluation and Control of Drugs (including principles of Pharmacovigilance)
6. Clinical trials and placebo effect
Special Pharmacology
1. The neurotransmission
- Adrenergic and cholinergic neurotransmission
- Dopaminergic neurotransmission
- Serotoninergic neurotransmission
- Histaminergic neurotransmission
- GABA-ergic neurotransmission
Drugs used to treat the diseases of the different organs and systems
2. Gastrointestinal system
- Drugs used to treat peptic ulcer
- Prokinetics,
- Emetics and antiemetics,
- Laxatives and anti-diarrheal drugs
3. Drugs used to treat diabetes mellitus (insulin and oral hypoglycemic agents)
4. Drugs used to regulate the fertility
5. Respiratory system
- Drugs used to treat asthma, COPD and and allergic rhinitis
- Anti cough drugs and mucolytics
6. Cardiovascular system
- Antihypertensives
- Antianginal drugs
- Antiarrhythmics
- Drugs used in heart failure
- Drugs for blood disorders
7. Musculoskeletal system
- Nonsteroidal anti-inflammatory drugs
- Glucocorticoids
8. Central nervous system
- Central analgesics
- Anxiolytic - hypnotics
- Antidepressants
- Pain therapy
- Drugs used in Parkinson's disease
- Drugs used in Alzheimer's disease
- Antipsychotic drugs
- Anticonvulsants
9. Antimicrobial chemotherapy
10. General principles of cancer chemotherapy.
Sezione: Rho
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Professor: Bottai Daniele
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: De Angelis Giuseppe
Sezione: Sacco
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professors: Arquati Massimo, Castelli Roberto
Farmacologia
Syllabus
Module program:
General pharmacology
- What is it and what does it involve pharmacology
- Drug / toxic Concept
- Discovery and development of new drugs and research phases
- Pharmacovigilance
- Definition of pharmacodynamics and pharmacokinetics
Pharmacodynamics
- Receptor Concept
- Receptor drug interaction: types of bonds
- Efficiency, Power, dose-response curve
- Therapeutic Index
- Drugs agonists and antagonists
- Antagonism competitive and non-competitive, chemical and functional
- The four superfamilies of receptors, channels, linked to G proteins, enzymes, and intracellular signal transduction
- Concept of receptor desensitization
Pharmacokinetics
- Routes of drug administration.
- Pharmaceutical Preparations
- Consumption of drugs
- Distribution of medicines
- Biotransformation of drugs
- Elimination of drugs.
- Main pharmacokinetic parameters.
Individual variability in drug response
- Placebo effect. Hypersensitivity. addiction
Interactions between drugs and between drugs and foods.
Special Pharmacology
1. Autonomic Nervous System
sympathetic and parasympathetic system. Adrenergic and cholinergic neurotransmission
agonists and antagonists that interfere with adrenergic transmission
agonists and antagonists that interfere with cholinergic transmission
Other Neurotransmission Systems
to. dopaminergic
b. serotonergic
c. histaminergic
d. GABAergic
2. Drugs used in diseases of the different apparatus and systems
For each system: Major classes of drugs, mechanisms of action, pharmacokinetics, methods of therapeutic use, side / toxic effects
Gastrointestinal system
- Drugs used in ulcer therapy,
- prokinetic drugs,
- Drugs emetics and antiemetics,
- Laxatives and anti-diarrheal drugs (outline)
Drugs used in the treatment of diabetes (insulin and oral hypoglycemic agents)
Respiratory system
- Drugs used in asthma therapy. and allergic rhinitis
- Drugs against the cough. and mucolytics (outline)
cardiovascular system
- Antihypertensive
- antianginal drugs
- antiarrhythmic drugs (outline)
- Drugs used in heart failure
- Drugs for blood disorders
Musculoskeletal system
- Nonsteroidal anti-inflammatory drugs
- Glucocorticoids.
Central nervous system
- Drugs central analgesics
- antianxiety drugs - hypnotic.
- Antidepressant medications.
- Pain therapy
- Drugs used in Parkinson's disease
- Drugs used in Alzheimer's disease
antimicrobial chemotherapy
- Main classes of antibacterial drugs and their clinical use
- Drugs active against the main protozoa, fungi, viruses
General principles of cancer chemotherapy and major classes of drugs.
Sezione: San Carlo
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: Lucini Daniela
Sezione: San Donato
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Professors: Pietrini Grazia, Vallar Lucia, Vicentini Lucia
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: Sampietro Maurizio
Sezione: San Giuseppe
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Professor: Lucini Valeria
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: Froldi Marco
Sezione: San Paolo
Active edition
Yes
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 60 hours
Professor: Lesma Elena Anna
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 4
Lessons: 60 hours
Professor: Faioni Elena Maria
Lesson period
year
Assessment methods
Esame
Assessment result
voto verbalizzato in trentesimi