Organometallic chemistry and fine chemical applications

A.Y. 2019/2020
8
Max ECTS
64
Overall hours
SSD
CHIM/03 CHIM/06
Language
Italian
Learning objectives
The course aims at giving the basis of organometallic chemistry. It represents an evolution of inorganic and organic chemistry, focusing on transition metal complexes reactivity with organic and inorganic ligands, especially chiral ones. The course offers an overview of their application in homogeneous catalysis.
Furthermore, the course aims to show the applications of transition-metals complexes on organic synthesis, in particular the use of homogeneous catalysis for the preparation of biological active compounds and natural products.
Expected learning outcomes
The expected learning outcomes will be focalized on:
- the development of a solid know-how in the field of organometallic chemistry and in its applications in research laboratories in academia or in industrial reality.
- the knowledge of modern synthetic methods used in academia or in industrial reality, exploiting the transition metals catalysis.
Course syllabus and organization

Unique edition

Responsible
Lesson period
Second semester
Prerequisites for admission
Good knowledge of inorganic and organic chemistry I and II
Assessement methods and criteria
Presentation and discussion on a free topic part of the program
Organometallic chemistry
Course syllabus
- Classification of ligands as defined by the Hard and Soft Acid Base theory (HSAB). Crystal field theory. Trans effect in coordination chemistry. Backbonding and electroneutrality principle. The 18-electron rule and its limitations. Ligand-field d-orbital splitting in transition metal complexes' formation. Different types of coordination geometries. Chirality in coordination complexes. Different ligands and the importance of their properties in coordination chemistry. Oxidative-addition and reductive-elimination: study of mechanism. Migratory insertion and isomerization reactions of olefins
- Ruthenium, Rhodium and Iridium: reactivity and their application in asymmetric catalysis. Copper, Silver and Gold: reactivity and their application in asymmetric catalysis. Peptides as innovative ligands in transition metal complexes.- An insight into the reactivity of metal-based enzymes. Hybrid catalysts and artificial metalloenzymes.
Teaching methods
Lectures
Bibliography
"The organometallic chemistry of the transition metals", Robert H. Crabtree, Wiley-Interscience
Fine chemical applications
Course syllabus
Homogeneous and heterogeneous catalysis. Formation of C-C, C-N, C-O bonds by using transition metals complexes. Reactions catalyzed by Pd(0)-complexes: Heck, Buchwald-Hartwig, cross-coupling, stereoselective reactions. Reactions catalyzed by Pd(II)-complexes: C-H activation, formation of C-C, C-N, C-O bonds. Domino reactions. Metathesis reactions catalyzed by Rutenium. Catalysis of different transition metals (Pt, Au, Cu, Rh, Ru). Comparison of different transition metals, stability, costs and user-friendliness. Choice of different catalysts applied to the syntheis of alkaloids and pharmaceuticals.
Teaching methods
Lectures
Bibliography
"The organometallic chemistry of the transition metals", Robert H. Crabtree, Wiley-Interscience
Fine chemical applications
CHIM/06 - ORGANIC CHEMISTRY - University credits: 4
Lessons: 32 hours
Organometallic chemistry
CHIM/03 - GENERAL AND INORGANIC CHEMISTRY - University credits: 4
Lessons: 32 hours