The course aims to develop knowledge on the pathogenic basis of human diseases, with particular attention to limits and benefits of the main experimental models available and their correlation with clinical presentation of the disease. It is based on a series of lectures grouped on thematic sections and focusing on pathogenic mechanisms and experimental approaches. The course also includes two journal club sessions held by the students on selected scientific articles proposed by the Faculty, aimed at developing the student's ability to critical reading, presentation, and discussion of the scientific data.
Students will acquire an integrated comprehension of the pathogenic basis of human pathology and on the correlation of pathogenic mechanisms and clinical manifestations. They will also acquire information on potentials and limitations of experimental models available. The journal club sessions will allow them to develop critical reading, presentation, and scientific data discussion abilities.
Immunomediated diseases Pathogen recognition and septic shock Immune escape mechanisms by pathogens The inflammasome and auto-inflammatory syndromes Inflammation resolution: molecular mechanisms and experimental models Pathogenic mechanisms in allergic diseases Pathogenic mechanisms in autoimmune diseases Pathogenic mechanisms in primary and acquired immunodeficiencies Transplantation immunology Liver transplant rejection The graft versus host disease: experimental models and implications for bone marrow transplant. Role of microbiota on immune activation
Oncology The immune contexture of solid tumors. Role of innate immunity in cancer Experimental approaches to study the immune contexture of solid tumors The immune contexture of solid tumors. Role of adaptive immunity in cancer Ovary carcinoma: clinical presentation and experimental models Molecular phenotypes of mammary carcinoma: clinical presentations and experimental models In vivo imaging techniques (CT, MRI, PET, SPECT, ultrasound)
Infectious diseases Pathogen recognition and septic shock Immunothrombosis: hemostasis and innate immunity interplay Soluble pathogen recognition receptors in infectious models Immune escape mechanisms in experimental infectious models
Iron metabolism and erythropoiesis Anemias Iron overload disorders Iron metabolism and hereditary hemochromatosis
Metabolic diseases The metabolic syndrome and type 2 diabetes Experimental models of insulin resistance and nonalcoholic fatty liver disease Pathophysiology and genetics of a complex disease: nonalcoholic steatohepatitis
Liver and kidney diseases Liver diseases (viral, cholestatic and autoimmune) and hepatocellular carcinoma Human genetics and models of metabolic diseases Kidney diseases Seminars: applications of stem cells for in vitro modelling and treatment of human disorders, applications of cytofluorimetry and cell sorting for the study of human diseases
Diseases of the cardiovascular system Thrombosis, thrombogenesis and thrombotic diseases Atherosclerosis and arterial thrombosis: coronary heart disease and ischemic cerebrovascular disease Venous thromboembolism Heart remodeling in systemic hypertension, heart failure, coronary heart disease, and atrial fibrillation Modeling biologic systems: network based simulation for translational medicine: an application to anticoagulation Antithrombotic pharmacological and non-pharmacological therapy
Aging and age-related diseases Aging Immune senescence and inflammaging Premature lung aging in the pathogenesis of respiratory diseases Cerebral aging and neurodegenerative diseases Alzheimer: pathogenesis and biomarkers