Pathogenetic basis of diseases

A.Y. 2019/2020
Lesson for
Overall hours
MED/04 MED/09
Learning objectives
The course aims to develop knowledge on the pathogenic basis of human diseases, with particular attention to limits and benefits of the main experimental models available and their correlation with clinical presentation of the disease. It is based on a series of lectures grouped on thematic sections and focusing on pathogenic mechanisms and experimental approaches. The course also includes two journal club sessions held by the students on selected scientific articles proposed by the Faculty, aimed at developing the student's ability to critical reading, presentation, and discussion of the scientific data.
Students will acquire an integrated comprehension of the pathogenic basis of human pathology and on the correlation of pathogenic mechanisms and clinical manifestations. They will also acquire information on potentials and limitations of experimental models available. The journal club sessions will allow them to develop critical reading, presentation, and scientific data discussion abilities.

Course structure and Syllabus

Active edition
General pathology and immunology
Lessons: 42 hours
Internal medicine
MED/09 - INTERNAL MEDICINE - University credits: 6
Lessons: 42 hours
General pathology and immunology
Immunomediated diseases
Pathogen recognition and septic shock
Immune escape mechanisms by pathogens
The inflammasome and auto-inflammatory syndromes
Inflammation resolution: molecular mechanisms and experimental models
Pathogenic mechanisms in allergic diseases
Pathogenic mechanisms in autoimmune diseases
Pathogenic mechanisms in primary and acquired immunodeficiencies
Transplantation immunology
Liver transplant rejection
The graft versus host disease: experimental models and implications for bone marrow transplant. Role of microbiota on immune activation

The immune contexture of solid tumors. Role of innate immunity in cancer
Experimental approaches to study the immune contexture of solid tumors
The immune contexture of solid tumors. Role of adaptive immunity in cancer
Ovary carcinoma: clinical presentation and experimental models
Molecular phenotypes of mammary carcinoma: clinical presentations and experimental models
In vivo imaging techniques (CT, MRI, PET, SPECT, ultrasound)

Infectious diseases
Pathogen recognition and septic shock
Immunothrombosis: hemostasis and innate immunity interplay
Soluble pathogen recognition receptors in infectious models
Immune escape mechanisms in experimental infectious models
Internal medicine
Iron metabolism and erythropoiesis
Iron overload disorders
Iron metabolism and hereditary hemochromatosis

Metabolic diseases
The metabolic syndrome and type 2 diabetes
Experimental models of insulin resistance and nonalcoholic fatty liver disease
Pathophysiology and genetics of a complex disease: nonalcoholic steatohepatitis

Liver and kidney diseases
Liver diseases (viral, cholestatic and autoimmune) and hepatocellular carcinoma
Human genetics and models of metabolic diseases
Kidney diseases
Seminars: applications of stem cells for in vitro modelling and treatment of human disorders, applications of cytofluorimetry and cell sorting for the study of human diseases

Diseases of the cardiovascular system
Thrombosis, thrombogenesis and thrombotic diseases
Atherosclerosis and arterial thrombosis: coronary heart disease and ischemic cerebrovascular disease
Venous thromboembolism
Heart remodeling in systemic hypertension, heart failure, coronary heart disease, and atrial fibrillation
Modeling biologic systems: network based simulation for translational medicine: an application to anticoagulation
Antithrombotic pharmacological and non-pharmacological therapy

Aging and age-related diseases
Immune senescence and inflammaging
Premature lung aging in the pathogenesis of respiratory diseases
Cerebral aging and neurodegenerative diseases
Alzheimer: pathogenesis and biomarkers

Journal Club Sessions
Lesson period
First trimester
Lesson period
First trimester
Assessment methods
Assessment result
voto verbalizzato in trentesimi
Educational website(s)
by appointment (e-mail request)
Marangoni pavilion, Policlinico IRCCS hospital, via F Sforza 35, Milan