Pharmacology and pharmacotherapy

A.Y. 2019/2020
8
Max ECTS
64
Overall hours
SSD
BIO/14
Language
Italian
Learning objectives
The course aims to prepare the student to understand the pharmacological basis of the therapy and the pharmacological profiles of the most commonly used drugs. Every single topic will be treated in terms of the pathophysiological description of the disease, the mechanism of action of the mainly used drugs and their profile of side effects.
Expected learning outcomes
The candidate must be able to demonstrate that he/she has understood the pharmacological profile and the rationale for each drug, demonstrating the ability to assess the benefit/risk ratio inherent to their use.
Course syllabus and organization

Linea AK

Linea AK
Responsible
Lesson period
First semester
Syllabus
General Pharmacology - Pharmacokinetics: absorption, distribution, biotransformation, elimination, interactions.
Central Nervous System drugs - Etiology of psychiatric disorders, mood disorders and antidepressant drugs; Schizophrenia and antipsychotic drugs; Bipolar disorder - antimanic medications and mood stabilizers; Anxiolytic and sedative-hypnotic drugs; Substances of abuse and drug addiction; Pharmacotherapy of Parkinson's disease; Pharmacotherapy of Alzheimer's disease and dementia; Pharmacotherapy of epilepsy: anticonvulsant drugs
Anesthetic drugs; Pain pharmacotherapy: narcotic and opioid analgesics.
Cardiovascular drugs - Atherosclerosis and ischemic heart disease. Lipid-lowering drugs. Treatment of obesity, diabetes mellitus, gout. Antihypertensive drugs: adrenergic agonists and antagonists; calcium channel blockers; modulators of potassium channels; nitro; diuretics; inhibitors of the renin-angiotensin-aldosterone system. Thrombolytics, antithrombotics and anticoagulants. Therapy of acute coronary syndromes and heart failure.
Autacoids and Inflammation - Non-steroidal anti-inflammatory drugs and steroids. Asthma therapy.
Gastrointestinal system drugs - Emetic and antiemetic drugs, drugs of gastric secretion and intestinal motility.
Chemotherapy - Immunomodulating agents. Antineoplastic agents: alkylating agents, antimetabolites, topoisomerase inhibitors, alkaloids, novel approaches to the therapy of neoplastic diseases. Antiviral agents. Antimicrobial agents: general considerations; sulfonamides and trimethoprim; agents affecting the synthesis of bacterial cell wall; agents inhibiting bacterial protein synthesis: aminoglycosides, tetracyclines, chloramphenicol, macrolides, oxazolidinones. Agents affecting nucleic acid synthesis: rifamycins, quinolones and fluoroquinolones.

Drugs for eating disorders
Pharmacology of the female gonadal axis
Pharmacology of the adrenal gland
Prerequisites, exams and assessment
General knowledge of physiology, pathology and biochemistry
Teaching methods
The aim of the course is make students able to understand the general mechanisms that regulate the drug-organism relationship and the action of drugs in different pathologies. At the end of the course the student should be able to know and understand the general and specific mechanisms of action of drugs and the pharmacotherapeutic guidelines in the main diseases. It should also have the cultural tools that make it able to independently study the areas of pharmacology not covered during the course, to follow the evolution of a discipline in continuous and rapid renewal, and to understand the rationale behind the development of new drugs.
The course provides notions on the action of drugs in pharmacokinetic terms (absorption, distribution, biotransformation, excretion), pharmacodynamics (mechanism of molecular, cellular, organ and apparatus action; toxicity) and pharmacotherapeutics (posology; combined therapies; notions of special pathology, indications, side effects, contraindications).
Teaching resources and bibliography
Farmacologia Generale e Clinica XIII Edizione
Katzung, Masters, Trevor
Editore: Piccin
Exam
Oral examination. The vote will be recorded in thirtieths.
BIO/14 - PHARMACOLOGY - University credits: 8
Lessons: 64 hours
Professor: Fumagalli Fabio

Linea LZ

Linea LZ
Responsible
Lesson period
First semester
Syllabus
General principles - Pharmacokinetics: drug absorption, distribution, metabolism, elimination. Drug interactions.

Drugs acting on the central nervous system - Etiology of psychiatric disorders, mood disorders and antidepressants; Schizophrenia and antipsychotic drugs; Bipolar disorder - antimanic drugs and mood stabilizers; Anxiolytic and sedative-hypnotic drugs; Substances of abuse and drug addiction; Parkinson's disease pharmacy; Pharmacotherapy of Alzheimer's and dementias; Pharmacotherapy of epilepsy: anticonvulsant drugs; Anesthetic drugs; Pain pharmacotherapy: narcotic and opioid analgesics.

Drugs affecting cardiovascular function - Atherosclerosis and ischemic heart disease. Drugs affecting lipid metabolism. Therapy of obesity, diabetes mellitus, and gout. Anti-hypertensive drugs: adrenergic agonists and antagonists, calcium channel blockers, potassium channel modulators, NO donors, diuretics, inhibitors of the renin-angiotensin-aldosterone system. Thrombolytic, antithrombotic and anticoagulant agents. Treatment of acute coronary syndromes and of heart failure.

Autacoids and inflammation - Steroidal and nonsteroidal anti-inflammatory agents. Treatment of asthma.

Drugs affecting gastrointestinal function - Emetics and anti-emetics, drugs affecting gastric acidity and intestinal motility.

Chemotherapy - Immunomodulating agents. Antineoplastic agents: alkylating agents, antimetabolites, topoisomerase inhibitors, alkaloids, novel approaches to the therapy of neoplastic diseases. Antiviral agents. Antimicrobial agents: general considerations; sulfonamides and trimethoprim; agents affecting the synthesis of bacterial cell wall; agents inhibiting bacterial protein synthesis: aminoglycosides, tetracyclines, chloramphenicol, macrolides, oxazolidinones. Agents affecting nucleic acid synthesis: rifamycins, quinolones and fluoroquinolones.

Drugs for eating disorders
Pharmacology of the female gonadal axis
Pharmacology of the adrenal gland
Prerequisites, exams and assessment
General knowledge of physiology, pathology and biochemistry
Teaching methods
Frontal lessons
Teaching resources and bibliography
Recommended books
· Basic and Clinical Pharmacology 14/e (LANGE Basic Science) 2018
Bertram Katzung
· Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e 2017
Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann
Exam
Examination At once
Methods of assessing knowledge Oral examination
Vote Vote verbalized (from 1/30 to 30/30)
BIO/14 - PHARMACOLOGY - University credits: 8
Lessons: 64 hours
Professor: Corsini Alberto