Research and development of new diagnostic and therapeutic metodologies

A.Y. 2016/2017
Lesson for
6
Max ECTS
42
Overall hours
SSD
BIO/11 MED/08 MED/15 MED/36
Language
English
Learning objectives
The aims of this course will be to provide an up-date knowledge of novel, emerging basic and technical aspects in the diagnosis and therapeutic approaches in cancer.
In particular, the course will be focused on mouse models, organoids, relevance of NGS in the context of tumor heterogeneity, the emerging role of non coding RNAs as therapeutic platforms, the advance of minimal residual disease approaches in the management of patients in the era
of new drugs, and the physical bases and possible applications of the most important imaging techniques
In particular, by following this course it will be possible to learn about:
Animal models as diagnostic and therapeutic tools
Rationale for NGS studies in cancer
The clinical relevance of the non coding RNAs
Molecular monitoring of hematological malignancies
Imaging techniques for clinical and pre-clinical oncological studies

Course structure and Syllabus

Active edition
Yes
Responsible
Blood diseases
MED/15 - BLOOD DISEASES - University credits: 2
Lessons: 14 hours
Molecular biology
BIO/11 - MOLECULAR BIOLOGY - University credits: 2
Lessons: 14 hours
Professor: Testa Giuseppe
Pathology
MED/08 - PATHOLOGY - University credits: 1
Lessons: 7 hours
Professor: Pruneri Giancarlo
Radiology
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 7 hours
Professor: Ottobrini Luisa
Pathology
Syllabus
The pathology lab: a platform for patients' diagnosis and therapy
Technologies and methods for assessing predictive factors in cancer patients.
Molecular follow-up of tumor resistance: the liquid biopsy model.
Pathology in the multidisciplinary team: from morphology to genome.
Radiology
Syllabus
Optical Imaging: Principles, methods and relevant procedures; pre-clinical applications
RX/CT and Ultrasound: Principles and methods for ultrasound imaging; clinical and pre-clinical applications
Magnetic Resonance Imaging (MRI): methodology, and advanced applications
Nuclear based techniques: Principles and methods of single photon emission tomography (SPECT),
positron emission tomography (PET) imaging procedures.
Blood diseases
Syllabus
Clonal heterogeneity in blood cancers by NGS
Novel classifications and their biological and prognostic relevance in hematological tumors
based on NGs study
Use of murine models for the study of mutations affecting splicing factors in the pathogenesis
of myeloid disorders.
Monitoring the minimal residual disease in hematological neoplasms:
technical advances and clinical implications
Non coding RNA in blood cancers: from genetic associations, molecular mechanisms, and therapeutic strategies
Molecular biology
Syllabus
Patient-specific tumor models: from xenografts to organoids.
Cancer reprogramming: from mechanism to tool for the dissection of tumor pathogenesis
and the identification of draggable pathways
Cancer-specific epigenetic dysregulation and its therapeutic application.
Lesson period
Third trimester
Lesson period
Third trimester
Assessment methods
Esame
Assessment result
voto verbalizzato in trentesimi