Toxicology

A.Y. 2019/2020
8
Max ECTS
64
Overall hours
SSD
BIO/14
Language
Italian
Learning objectives
- Characterize the manifestation and mechanisms of toxicity
- Provide scientific basis for experimental toxicology and criteria for evaluating and extrapolating toxicity data to humans
- Provide adequate toxicological knowledge and valid bases for defining the criteria for protecting human health from the risks deriving from the direct (drugs, food additives, etc.) or indirect exposure (environmental pollutants, industrial solvents, etc.) of substances (chemical and biological).
Expected learning outcomes
Knowledge and understanding of the main aspects of toxicology with particular reference to general and organ toxicity of xenobiotics
Course syllabus and organization

Linea AK

Linea AK
Responsible
Lesson period
Second semester
Syllabus
GENERAL PRINCIPLES OF TOXICOLOGY
· Principles of Toxicology
· Mechanisms of Toxicity
· Methods of in vitro toxicology
NON-ORGAN-DIRECTED TOXICITY
· Developmental toxicology
· Genetic toxicology
· Carcinogenesis
TARGET ORGAN TOXICITY
· Toxic responses of the respiratory system
· Toxic responses of the immune system
· Toxic responses of the Nervous System
· Toxic responses of the kidney
· Toxic responses of the liver
· Toxic responses of the skin
· Toxic responses of the heart
· Toxic responses of the ocular and visual system
CHEMICAL AND PHYSICAL AGENTS TOXICITY
· Pesticides
· solvents
· radioactivity
· Metals
· Natural Toxins
RISK ASSESSMENT
· Risk assessment
Prerequisites, exams and assessment
Knowledge of basic human anatomy and principles of biology
Teaching methods
The course is based on both lessons and active discuss on the content of each general chapter.
Slides of the course are provided on Ariel web-site: https://ariel.unimi.it
Teaching resources and bibliography
· Tossicologia, Galli-Corsini-Marinovich, editore PICCIN, 2 Edizione (2008)
· Casarett & Doull's -Tossicologia, Ed. Curtis D.Klaassen, 5° edizione (vers. italiana) EMSI - Roma
· Tossicologia cellulare e molecolare, Ed. G. Cantelli Forti, P. Hrelia, C.L.Galli, M. Marinovich, UTET (2000)
· Casarett & Doull's -Toxicology, The basic science of poisons, Fifth edition (1999), Ed. C.D. Klaassen , J.B. Watkins III°, McGraw Hill
· General & Applied Toxicology, Ed. B. Ballantyne, T. Marrs, P. Turner, MacMillan Press
Exam
Aim of the course is to provide basic knowledge on the principles of toxicology through the characterization of the main mechanisms of toxicity at both cellular and organ level and through the mechanisms of differente classes of chemicals. Acquisition of these competences will be evaluated by oral examination on any topic of the program.
BIO/14 - PHARMACOLOGY - University credits: 8
Lessons: 64 hours
Professor: Viviani Barbara

Linea LZ

Linea LZ
Responsible
Lesson period
Second semester
Syllabus
· Principles of Toxicology
· Understanding of the concepts of general pharmacology applied to toxicology (relationship dose-effect, risk, local and systemic effects, secondary effects, and toxic effects of drugs and other xenobiotics.
· Toxicokinetics and Toxicodynamics
· Concepts related to the absorption and the biotransformation of drugs and other xenobiotics and their elimination.
· Molecular mechanisms of toxicity
· Understanding of the primary mechanisms of cellular toxicity, definition of apoptosis and necrosis and markers of cellular damage.
· Relevant classes of toxicants (metals, natural toxins, pesticides, solvents, etc..)
· Main systems and target organs of toxic substances (including the effects of genotoxicants, carcinogens and teratogens)
· Pre-Clinical experiments and main toxicological tests
· Diet-drugs interactions
· Concept of human risk
· Definition of the protection criteria of human health from the risk deriving from the direct intake (drugs, food additives, etc.) or indirect intake (environmental pollution, industrial solvents, etc.) of chemical and biological substances.
Prerequisites, exams and assessment
Basic knowledge of biochemistry, physiology, cell biology and pharmacology
Teaching methods
Lectures
Teaching resources and bibliography
Tossicologia, Galli-Corsini-Marinovich, editore PICCIN, 3 Edizione (2016)
· Casarett & Doull's -Tossicologia, Ed. Curtis D.Klaassen, 5° edizione (vers. italiana) EMSI - Roma
· Tossicologia cellulare e molecolare, Ed. G. Cantelli Forti, P. Hrelia, C.L.Galli, M. Marinovich, UTET (2000)
· Casarett & Doull's -Toxicology, The basic science of poisons, Fifth edition (1999), Ed. C.D. Klaassen , J.B. Watkins III°, McGraw Hill
· General & Applied Toxicology, Ed. B. Ballantyne, T. Marrs, P. Turner, MacMillan Press
Exam
The exam consists of an oral discussion which focuses on topics covered in the course
BIO/14 - PHARMACOLOGY - University credits: 8
Lessons: 64 hours
Professor: Marinovich Marina