Anatomical bases and molecular networks in the Central Nervous system and its pathologies

A.Y. 2015/2016
8
Max ECTS
60
Overall hours
SSD
VET/01 VET/03
Language
English
Learning objectives
Undefined
Expected learning outcomes
Undefined
Course syllabus and organization

Single session

Responsible
Lesson period
Second semester
ATTENDING STUDENTS
Unità didattica: Morphology and Function of the CNS
Course syllabus
Lectures
CNS organization; Neurons, Ganglia and Nerves (2 hours)
Internal capsule and ventricles; Willis circulatory system (1 hour)
CNS: Brain and cortical areas, pons, midbrain, diencephalon, basal ganglia, cerebellum (3 hours)
Neurotransmitters and neuromodulators of the SNC. Spinal cord (1 hour)
Ascending pathways, somatosensory systems. Descending pathways, motor systems (1 ora)
Development of the brain, spinal cord, and nerves. (1 hour)
Neurogenic areas in the brain (1 hour)
Gene regulation of neurogenesis, differentiation of neural progenitors. (1 hour)
The neurogenic niche. Engrafting and homing of neural progenitorsi. Neuro-phenotype-related experiments using knock -out mice (2 hours)
Sympathetic System (1 hour),
Paraympathetic System (1 hour),
Enteric (1 hour);
Neuroendocrine: Hypotalamus, Pituitary and Pineal glands (2 hours);
Action Potentials and nervous transmission. Myelinization and salutatory transmission (2 hours)
Synapsis. Neuro-muscular junctions; Eccitatoty and inhibitory Neurotransmitters, Reuptake (3 hours)

Practical training
Microscopy session on Neurons, Ganglia and Nerves (2 hours)
Microscopy session on Neural tissue sections (2 hours)
Microscopy session on Spinal cord (C3;T2,L4) (2 hours)
Confocal images of Pituitary and Pineal glands (2 hours)
Microscopy session on Sciatic Nerve (2 hours)
Gap junctions and Synapsis (2 hours)
Data acquisition and analysis from confocal images (2 hours)
Data acquisition and analysis from MRI images (2 hours)
Unita' didattica: Molecular pathology of the CNS
Course syllabus
Lectures:
1. Ageing and Oxidative stress
2. Conformational diseases 1: the Transmissible Spongiform encephalopaties
3. Conformational diseases 2: Alzheimer diseases
4. Conformational diseases 3: Parkinson/Huntington disease
5. Degenerative diseases affecting motoneurons: Amyothrophic Lateral Sclerosis
6. Demyelination diseases: Multiple sclerosis

Practices
- Determination of oxidative stress in tissues and biological fluids
- Determination of apoptosis on cells and tissues
- Specific lectures on neuropathology
NON-ATTENDING STUDENTS
Unità didattica: Morphology and Function of the CNS
Course syllabus
Lectures
CNS organization; Neurons, Ganglia and Nerves (2 hours)
Internal capsule and ventricles; Willis circulatory system (1 hour)
CNS: Brain and cortical areas, pons, midbrain, diencephalon, basal ganglia, cerebellum (3 hours)
Neurotransmitters and neuromodulators of the SNC. Spinal cord (1 hour)
Ascending pathways, somatosensory systems. Descending pathways, motor systems (1 ora)
Development of the brain, spinal cord, and nerves. (1 hour)
Neurogenic areas in the brain (1 hour)
Gene regulation of neurogenesis, differentiation of neural progenitors. (1 hour)
The neurogenic niche. Engrafting and homing of neural progenitorsi. Neuro-phenotype-related experiments using knock -out mice (2 hours)
Sympathetic System (1 hour),
Paraympathetic System (1 hour),
Enteric (1 hour);
Neuroendocrine: Hypotalamus, Pituitary and Pineal glands (2 hours);
Action Potentials and nervous transmission. Myelinization and salutatory transmission (2 hours)
Synapsis. Neuro-muscular junctions; Eccitatoty and inhibitory Neurotransmitters, Reuptake (3 hours)

Practical training
Microscopy session on Neurons, Ganglia and Nerves (2 hours)
Microscopy session on Neural tissue sections (2 hours)
Microscopy session on Spinal cord (C3;T2,L4) (2 hours)
Confocal images of Pituitary and Pineal glands (2 hours)
Microscopy session on Sciatic Nerve (2 hours)
Gap junctions and Synapsis (2 hours)
Data acquisition and analysis from confocal images (2 hours)
Data acquisition and analysis from MRI images (2 hours)
Unita' didattica: Molecular pathology of the CNS
Course syllabus
Lectures:
1. Ageing and Oxidative stress
2. Conformational diseases 1: the Transmissible Spongiform encephalopaties
3. Conformational diseases 2: Alzheimer diseases
4. Conformational diseases 3: Parkinson/Huntington disease
5. Degenerative diseases affecting motoneurons: Amyothrophic Lateral Sclerosis
6. Demyelination diseases: Multiple sclerosis

7. Determination of oxidative stress in tissues and biological fluids
8. Apoptosis
Unità didattica: Morphology and Function of the CNS
VET/01 - VETERINARY ANATOMY - University credits: 0
VET/03 - VETERINARY PATHOLOGY - University credits: 0
Practicals: 12 hours
Lessons: 24 hours
Professor: Brevini Tiziana
Unita' didattica: Molecular pathology of the CNS
VET/01 - VETERINARY ANATOMY - University credits: 0
VET/03 - VETERINARY PATHOLOGY - University credits: 0
Practicals: 12 hours
Lessons: 12 hours
Professor: Ceciliani Fabrizio
Professor(s)
Reception:
After scheduling via mail
Department of Veterinary Medicine - Room 172