The course aims to provide: (1) an introduction to nanotechnology and to fabrication and characterization methods for nano and microstructured systems and (2) basic knowledge on the use of nano-scale aggregates of synthetic and natural polymers for diagnostic or therapeutic purposes.
Expected learning outcomes
Lesson period: First semester
(In case of multiple editions, please check the period, as it may vary)
Introduction to nanotechnology. Definition, classification and structure of nanostructured systems, Nanofabrication methods. Nanoparticles production, characterization and assembling. Optical properties of nanoparticles. Nanostructured system imaging: scanning probe microscopies. Atomic force microscopy for bioapplications. Biocompatible nanostructured materials. Microfabrications: an introduction. Lab-on chip: integration of micro- and nanosystems.
Basic concepts in polymer science: definition of macromolecule, molecular weight distribution, chemical and physico-chemical properties of polymers. Nanostructured polymers for biotechnological applications: polymer stabilized liposomes, polymeric micelles, bioerodible nano- and microparticles, dendrimers, nanogels for controlled delivery of drugs and diagnostic probes. DNA-polymer complexes ("polyplexes") for gene therapy. Nano- and micropatterned hydrogels in tissue engieneering and microfluidics.