This course is designed to provide the fundamental knowledge to understand the concepts of biochemistry processes that control the functioning and homeostasis of cells and body in physiological and pathophysiological conditions.
ABC TRANSPORTERS Structure Mechanism of action Role in cell physiology Role in drug resistance
MEMBRANE LIPIDS: ARCHITECTURE, DYNAMICS AND BIOLOGICAL FUNCTIONS In/out asymmetry and lateral asymmetry in pathophysiological processes Aminophospholipids in membrane fusion, cytokinesis clotting, phagocytosis and apoptosis Phosphosinositides: compartimentalization, vesicular traffic and cell signaling (Glyco)sphingolipids: Lipid Microdomains, signaling platforms, cell-cell communication
Lipids and cell signaling Lipid mediators in the control of cell proliferation, death and migration: Ceramide , Sphingosine-1-phosphate and Diacylglicerol "Omics" in lipid signaling
HUMAN BIOCHEMISTRY Tissue-specific metabolic processes: Lipoproteins, structure, metabolism, and their role in the regulation of lipid homeostasis. Structural and metabolic alterations of lipoproteins and atherosclerosis. Liver, adipose tissue muscle metabolic adaptation in physiological conditions (metabolic diseases, aging....)
Biochemistry of the nervous system: Metabolism and functions: neurons-glia interactions. Specialized functions of cells of the nervous system Cell models for the study of biochemical processes in cells of the nervous system
Biochemistry of cancer: Metabolic processes in the tumor cells Aberrant glycosylation in the tumor Cell models
Laboratory sections: Characterization of lipid composition in cell extracts