The programme contains a general section and a systematic section. The latter, besides showing the main goals achieved by the medicinal chemistry research, is meant to give a practical application of the concepts presented in the general section. The two sections can be summarized as follows:
General Section Aspects and aims of the medicinal chemistry research. Drug design: modern and traditional approach. New technologies. Prodrugs. Receptors and enzymes. Drug-target interaction. Pharmacophore. Pharmacokinetics (ADMET), general concepts. Chirality in medicinal chemistry. Intellectual property and market.
Systematic section Chemotherapeutics: general considerations and classification. Antimetabolites. Sulfonamides. Antitubercolosis drugs. Antimalarial drugs. Antifungal drugs. Quinolone derivatives. Antibiotics: inhibitors of the bacterial wall synthesis, protein synthesis inhibitors, nucleic acid synthesis inhibitors, compound which act on the bacterial cell membrane. Antitumor drugs. Antiviral drugs. Antidiabetics. Steroids. Vitamines. Natural compounds as a source for new drugs.
At the end of the course the student will sustain a written and an oral exam.