Methods in pharmacology and toxicology

A.Y. 2015/2016
6
Max ECTS
48
Overall hours
SSD
BIO/14
Language
Italian
Learning objectives
The aim of this course is to present the key experimental technologies and approaches to investigate pharmacological and toxicologies pathways in the context of cardiometabolic disorders.
Expected learning outcomes
Undefined
Course syllabus and organization

Single session

Lesson period
Second semester
Course syllabus
-Regulation and guidelines for the use animal models in experimental research.
-Regulation and guidelines for clinical and genetic studies.
-Physiopathology of cardiovascular and immunometabolic diseases.
-Animal models for the study of obesity and metabolic diseases.
-Animal models for the study of atherosclerosis.
-Platelet aggregation and models for the study of arterial thrombosis.
-Experimental approaches for the study of endothelial function and angiogenesis.
-Immune diseases.
-Experimental approaches for the study of leukocytes subsets in humans and animal models.
-Investigation of oxidative stress in the heart.
-Imaging procedures in vascular biology.
-Imaging procedures in metabolic disorders.
-Clinical Studies
-Pharmacogenetics
-Biothecnological drugs
-From gene identification to target therapies: the example of humanized monoclonal antibodies
-Tests for mutagenesis
-Tests for cancerogenesis
-Teratogenesis
-Drug toxicity
-Pharmacovigilance



Modalities of examination
The examination will consist of an oral discussion of the topics of the programme.

Material
The slides of the course are available on the Ariel platform.
Suggested books:
Tossicologia molecolare e cellulare, Paoletti et al UTET
Tossicologia-Helmut Greim Zanichelli
Elementi di Tossicologia. Casarett and Doull, casa Editrice Ambrosiana

Additional information
http://www.ccdbiol.unimi.it
BIO/14 - PHARMACOLOGY - University credits: 6
Lessons: 48 hours
Professor(s)