Organic Chemistry 2 and Organic Chemistry Laboratory
A.Y. 2015/2016
Learning objectives
Undefined
Expected learning outcomes
Undefined
Lesson period: First semester (In case of multiple editions, please check the period, as it may vary)
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Course syllabus and organization
Linea A-K
Responsible
Lesson period
First semester
Organic Chemistry 2
Course syllabus
1- Amino acids and peptides: chemical-physical properties and synthesis of amino acids; protecting groups and peptide synthesis.
2- Aromatic compounds. Chemistry of benzene and naphthalene, aromaticity and substituent effects. Mechanisms of electrophilic substitution (halogenation, nitration, sulfonation, Friedel-Craft's alkylation and acylation) and nucleophilic substitution (SnAr, benzyne intermediate). Diazonium salts: synthesis and reactivity. Some classes of compounds will be studied in detail according to their particular importance.
3- Sulfur compounds
3- Enol and enolate chemistry, enamines: termodinamic and kinetic aspects of enolization, enolate and enamines formation and stabilization; synthetic application of base and acid catalyzed aldol reactions, Claisen and Dieckmann condensations. Alkylations, acetoacetic and malonic reactions. Mannich, Henry, Knoevenagel, Wittig reactions and Robinson annulation. Theoretical aspects and reactivity of electron-poor alkenes.
4- Heterocyclic compounds and their nomenclature. A general overview on the reactivity of the most important 5-member (pyrrole, thiophene, furan, oxazole, imidazole, thiazole, isoxazole) and 6-member (pyridine and quinoline) heterocyclic nucleus and their syntheses.
5- Some lessons will concern theoretical and practical exercises.
2- Aromatic compounds. Chemistry of benzene and naphthalene, aromaticity and substituent effects. Mechanisms of electrophilic substitution (halogenation, nitration, sulfonation, Friedel-Craft's alkylation and acylation) and nucleophilic substitution (SnAr, benzyne intermediate). Diazonium salts: synthesis and reactivity. Some classes of compounds will be studied in detail according to their particular importance.
3- Sulfur compounds
3- Enol and enolate chemistry, enamines: termodinamic and kinetic aspects of enolization, enolate and enamines formation and stabilization; synthetic application of base and acid catalyzed aldol reactions, Claisen and Dieckmann condensations. Alkylations, acetoacetic and malonic reactions. Mannich, Henry, Knoevenagel, Wittig reactions and Robinson annulation. Theoretical aspects and reactivity of electron-poor alkenes.
4- Heterocyclic compounds and their nomenclature. A general overview on the reactivity of the most important 5-member (pyrrole, thiophene, furan, oxazole, imidazole, thiazole, isoxazole) and 6-member (pyridine and quinoline) heterocyclic nucleus and their syntheses.
5- Some lessons will concern theoretical and practical exercises.
Organic Chemistry 2
CHIM/06 - ORGANIC CHEMISTRY - University credits: 6
Lessons: 48 hours
Professor:
Gelmi Maria Luisa
Organic Chemistry Laboratory
CHIM/06 - ORGANIC CHEMISTRY - University credits: 4
Single bench laboratory practical: 64 hours
Professors:
Erba Emanuela, Gelmi Maria Luisa
Shifts:
Turno 1
Professor:
Erba EmanuelaTurno 2
Professor:
Gelmi Maria LuisaLinea L-Z
Responsible
Lesson period
First semester
Organic Chemistry 2
Course syllabus
1- Amino acids and peptides: chemical-physical properties and synthesis of amino acids; protecting groups and peptide synthesis.
2- Aromatic compounds. Chemistry of benzene and naphthalene, aromaticity and substituent effects. Mechanisms of electrophilic substitution (halogenation, nitration, sulfonation, Friedel-Craft's alkylation and acylation) and nucleophilic substitution (SnAr, benzyne intermediate). Diazonium salts: synthesis and reactivity. Some classes of compounds will be studied in detail according to their particular importance.
3- Sulfur compounds
3- Enol and enolate chemistry, enamines: termodinamic and kinetic aspects of enolization, enolate and enamines formation and stabilization; synthetic application of base and acid catalyzed aldol reactions, Claisen and Dieckmann condensations. Alkylations, acetoacetic and malonic reactions. Mannich, Henry, Knoevenagel, Wittig reactions and Robinson annulation. Theoretical aspects and reactivity of electron-poor alkenes.
4- Heterocyclic compounds and their nomenclature. A general overview on the reactivity of the most important 5-member (pyrrole, thiophene, furan, oxazole, imidazole, thiazole, isoxazole) and 6-member (pyridine and quinoline) heterocyclic nucleus and their syntheses.
5- Some lessons will concern theoretical and practical exercises.
2- Aromatic compounds. Chemistry of benzene and naphthalene, aromaticity and substituent effects. Mechanisms of electrophilic substitution (halogenation, nitration, sulfonation, Friedel-Craft's alkylation and acylation) and nucleophilic substitution (SnAr, benzyne intermediate). Diazonium salts: synthesis and reactivity. Some classes of compounds will be studied in detail according to their particular importance.
3- Sulfur compounds
3- Enol and enolate chemistry, enamines: termodinamic and kinetic aspects of enolization, enolate and enamines formation and stabilization; synthetic application of base and acid catalyzed aldol reactions, Claisen and Dieckmann condensations. Alkylations, acetoacetic and malonic reactions. Mannich, Henry, Knoevenagel, Wittig reactions and Robinson annulation. Theoretical aspects and reactivity of electron-poor alkenes.
4- Heterocyclic compounds and their nomenclature. A general overview on the reactivity of the most important 5-member (pyrrole, thiophene, furan, oxazole, imidazole, thiazole, isoxazole) and 6-member (pyridine and quinoline) heterocyclic nucleus and their syntheses.
5- Some lessons will concern theoretical and practical exercises.
Organic Chemistry 2
CHIM/06 - ORGANIC CHEMISTRY - University credits: 6
Lessons: 48 hours
Professor:
Beccalli Egle Maria
Organic Chemistry Laboratory
CHIM/06 - ORGANIC CHEMISTRY - University credits: 4
Single bench laboratory practical: 64 hours
Professors:
Erba Emanuela, Rossi Elisabetta
Shifts:
Turno 3
Professor:
Rossi ElisabettaTurno 4
Professor:
Erba Emanuela