Organic Chemistry 2 and Organic Chemistry Laboratory

1- Amino acids and peptides: chemical-physical properties and synthesis of amino acids; protecting groups and peptide synthesis.
2- Aromatic compounds. Chemistry of benzene and naphthalene, aromaticity and substituent effects. Mechanisms of electrophilic substitution (halogenation, nitration, sulfonation, Friedel-Craft's alkylation and acylation) and nucleophilic substitution (SnAr, benzyne intermediate). Diazonium salts: synthesis and reactivity. Some classes of compounds will be studied in detail according to their particular importance.
3- Sulfur compounds
3- Enol and enolate chemistry, enamines: termodinamic and kinetic aspects of enolization, enolate and enamines formation and stabilization; synthetic application of base and acid catalyzed aldol reactions, Claisen and Dieckmann condensations. Alkylations, acetoacetic and malonic reactions. Mannich, Henry, Knoevenagel, Wittig reactions and Robinson annulation. Theoretical aspects and reactivity of electron-poor alkenes.
4- Heterocyclic compounds and their nomenclature. A general overview on the reactivity of the most important 5-member (pyrrole, thiophene, furan, oxazole, imidazole, thiazole, isoxazole) and 6-member (pyridine and quinoline) heterocyclic nucleus and their syntheses.
5- Some lessons will concern theoretical and practical exercises.

1- Amino acids and peptides: chemical-physical properties and synthesis of amino acids; protecting groups and peptide synthesis.
2- Aromatic compounds. Chemistry of benzene and naphthalene, aromaticity and substituent effects. Mechanisms of electrophilic substitution (halogenation, nitration, sulfonation, Friedel-Craft's alkylation and acylation) and nucleophilic substitution (SnAr, benzyne intermediate). Diazonium salts: synthesis and reactivity. Some classes of compounds will be studied in detail according to their particular importance.
3- Sulfur compounds
3- Enol and enolate chemistry, enamines: termodinamic and kinetic aspects of enolization, enolate and enamines formation and stabilization; synthetic application of base and acid catalyzed aldol reactions, Claisen and Dieckmann condensations. Alkylations, acetoacetic and malonic reactions. Mannich, Henry, Knoevenagel, Wittig reactions and Robinson annulation. Theoretical aspects and reactivity of electron-poor alkenes.
4- Heterocyclic compounds and their nomenclature. A general overview on the reactivity of the most important 5-member (pyrrole, thiophene, furan, oxazole, imidazole, thiazole, isoxazole) and 6-member (pyridine and quinoline) heterocyclic nucleus and their syntheses.
5- Some lessons will concern theoretical and practical exercises.