Physiopathology, introduction in biotechnologies diagnostic and therapy

A.Y. 2015/2016
Overall hours
MED/06 MED/09 MED/13 MED/15 MED/18 MED/26
Learning objectives
The training course has the following aims:
- Comprehension of the main physiological systems and their related pathophysiology
- Comprehension of the principles of diagnostic and therapy in liquids and solids tumors
Expected learning outcomes
The course aims to provide students with the basic knowledge of the major human diseases and the processes that cause them, in order to provide the necessary background for understanding the role of the biotechnology tools employed in diagnostics and therapy of these alterations. To this end, the course is structured in a series of lectures regarding the pathophysiology of the main systems complemented by lectures on the possible biotechnological approaches related to the diagnostics and treatment of the analyzed diseases.
Course syllabus and organization

Single session

Lesson period
First semester
Modulo: Fisiopatologia medica
Course syllabus
Pathophysiology of the Nervous System:
- Neurodegenerative diseases
Alzheimer's disease and frontotemporal dementia
Parkinson's disease
- Motor neuron diseases:
Amyotrophic lateral sclerosis (ALS)
Kennedy disease
Spinal muscular atrophy (SMA)
Hereditary spastic paraplegia

Pathophysiology of the Cardiovascular System:
The heart as a pump and the valvular heart diseases
The heart rhythm disorders
Heart failure
Ischemic heart disease
The Hypertension
The vascular occlusive disease
The vascular system

Pathophysiology of the Respiratory System:
The acute respiratory failure
The chronic respiratory failure

Pathophysiology of the Endocrine:
Role of biotechnology in the management of endocrine tumors (oncogenes and tumor suppressor);
Premature ovarian failure: menopausal age prediction and tools for fertility preservation;
Pathophysiology of GnRH neuron: molecular diagnostics and fertility biotech drugs;
Sensitivity problems and promiscuity hormonal action

Pathophysiology and clinical surgery of the urinary apparatus: Acute renal failure and chronic

Pathophysiology of the liver: Hepatitis viruses and viral hepatitis

Pathophysiology of the Hematopoietic System:
Iron metabolism and related conditions
Modulo: Principi di diagnostica e terapia biotecnologica
Course syllabus
Principles of diagnostics and therapy in hematology:
Hematopoiesis and its diagnostics
New methods to study tumor transformation in hematology
Haemostasis and Thrombosis
The hematopoietic stem cell
Myeloproliferative diseases
Lymphoproliferative diseases
Plasma cells disorders
Concepts of hematopoietic stem cell transplantation
Minimal residual disease in onco-hematology: methods and applications;
Molecular therapy in hematology: new drugs and monoclonal antibodies;
Outline of methodology in clinical research

Principles of diagnostics and therapy in oncology:
Principles of tumor biology: mechanisms of neoplastic transformation
Cancer stem cells
New drugs and monoclonal antibodies
Modulo: Fisiopatologia medica
MED/09 - INTERNAL MEDICINE - University credits: 0
MED/13 - ENDOCRINOLOGY AND METABOLISM - University credits: 0
MED/15 - BLOOD DISEASES - University credits: 0
Informal teaching: 8 hours
Lessons: 45 hours
Professors: Corradini Paolo, Neri Antonino, Persani Luca, Sampietro Maurizio
Modulo: Principi di diagnostica e terapia biotecnologica
MED/06 - MEDICAL ONCOLOGY - University credits: 0
MED/18 - GENERAL SURGERY - University credits: 0
MED/26 - NEUROLOGY - University credits: 0
Informal teaching: 8 hours
Lessons: 35 hours
Professors: Carlo Stella Carmelo, Ferraresso Mariano, Ratti Antonia