Advanced molecular biology

A.Y. 2016/2017
Overall hours
Learning objectives
The course of Advanced Molecular Biology aims at providing a deep overview of the mechanisms controlling cell division and proliferation and how the cell cycle mechanisms are integrated with processes required to maintain the integrity of the genome. These topics will be discussed in model organims and in mammalian cells, with a particular focus on human pathologies linked to alterations in the molecular mechanisms of these processes.
Expected learning outcomes
Course syllabus and organization

Single session

Lesson period
First semester
Course syllabus
- The Cell Cycle
- Model organisms in the cell cycle analysis
- The cell cycle control systems
- The control of S phase
- Molecular mechanisms and control of mitosis
- Completion of mitosis and cell division
- Control of cell proliferation and growth
- Processes that compromise genome integrity
- DNA repair and DNA damage tolerance mechanisms
- Pathologies related to increased genome instability
- Cell cycle checkpoints in physiological and pathological conditions
- The cell cycle in cancer and other human diseases.
- Mechanisms responsible for the maintenance of genome integrity as targets for anticancer therapy

Reference Material
-D.O. Morgan. The Cell Cycle: principles of control New Science Press.
-Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A. & Ellenberger, T. DNA repair and mutagenesis (ASM Press).
-Friedberg E.C., Elledge S.J, Lehmann A.R., Lindahl T., Muzi Falconi M. DNA Repair, Mutagenesis, and Other Responses to DNA Damage: A Subject Collection from Cold Spring Harbor Perspectives in Biology
Scientific papers and reviews will be indicated during the course

Prerequisites and examination procedures
Good knowledge of Molecular Biology, Genetics and Biochemistry is required.
Written exam (open questions); students that regularly attend the course will have the possibility to go through an intermediate exam covering approximately half the program and then a final exam at the end of the course.

Recommended Prerequisites

Teaching Methods
Traditional lectures supported by slides
Regular attendance is strongly suggested.

Language of instruction

Program information
Copies of the slides used during the lectures will be available through the Ariel platform

WEB pages
BIO/11 - MOLECULAR BIOLOGY - University credits: 6
Lessons: 48 hours
Professor: Muzi Falconi Marco