Main goals The course aims to give students a good understanding of the main application areas in which organic chemistry plays an important role. The teaching module provides several examples of industrial scale synthesis, and industrial application, of active principles. Some products and intermediates of industrial interest will be prepared and characterized in the laboratory module.
Program Pharmaceutical research - 24 hours: identification of a target, discovery of hits and leads, structural optimization of active leads, synthetic strategies on a large scale. Identification of kinesins as anticancer targets through chemical genetics, development of MK-731 as an anticancer compound. Identification of kinase inhibitors using fragment-based drug discovery, development of AT519 as an antitumor compound. Discovery of statins as drugs against hypercholesterolemia, development and commercialization of fluvastatin-LescolTM. Discovery of -lactams and cephalosporins, industrial synthesis of ceftibuten. Agro research - 6 hours: herbicides, fungicides and insecticides. Field use, industrial and environmental issues. Rational design and synthesis of neonicotinoid insecticides, development and commercialization of imidacloprid. Homogeneous, heterogeneous, and bio-catalysis - 6 hours. Guiding principles in the design of new catalysts. Monsanto process for the synthesis of L-DOPA. DIPAMP, DuPHOS and BINAP in asymmetric reductions. Energy and Environment - 6 hours: renewable energy, greenhouse effect, carbon sources. Methanol fuel cells, dye-sensitized solar cells. Complexes of Ru and organic ligands as dye-sensitizers. Nanotechnology - 6 hours: definitions, physical and chemical phenomena at the nano-scale, industrial applications. Fullerenes, carbon nanotubes and graphene: synthesis using physical and organic-chemical methods, covalent and noncovalent functionalization, properties. The laboratory module will include the synthesis of ferrocene, and its functionalization with chemical groups useful for the synthesis of industrially relevant ferrocenic compounds. Supporting material - The full contents of the teaching- theoretical module are provided as electronic pdf files downloadable by students at the ARIEL UniMi Website. - The same ARIEL site also contains several recent papers and reviews which are cited and descrive throughout the teaching module. - Supporting material for the lab module will be provided by the teacher at the start of the lab module.
Propedeutic courses, assessment methods Principles of organic and industrial chemistry Assessment methods - theoretical module: oral Students will have to provide the lab teacher with a final report at the end of the lab module.
Additional information Attendance: highly recommended Course level: advanced