Developmental biology

A.Y. 2016/2017
6
Max ECTS
48
Overall hours
SSD
BIO/01 BIO/06
Language
Italian
Learning objectives
The course will introduce the student to the most important aspects of the developmental Biology and to the most significative model organisms employed in developmental studies. The course will also discuss the use of mutants and the most important techniques daily used by the researchers in this field.
Expected learning outcomes
Undefined
Course syllabus and organization

A - L

Responsible
Lesson period
First semester
Course syllabus
Animal developmental biology:
- From fertilized egg to the individual: developmental genetic and epigenetic program.
- Tissue differentiation and stem cells.
- Animal models used in developmental biology.
- Fertilization.
- Developmental phases: segmentation, gastrulation, organogenesis, morphogenesis.
- Body axis formation: antero-posterior and dorso-ventral development.
- Induction: insights on embryonic cell-cell communication.
- Vertebrate limb development.
- Experimental embryology: normal and abnormal development.

Plant developmental biology:
- Differences and similarities between plant and animal development
- Plant model systems
- Developmental drivers: asymmetric cell division, morphogenic gradients and transcriptional regulation
- Embryo development
- Development and maintenance of the shoot apical meristem
- Development of the root apical meristem
- Positioning of lateral organs on the main stem and acquisition of leaf identity and polarity
- Floral transition in response to seasonal cues (cold and photoperiod)
- Flower development


Tutorials
Reference Material S.F. Gilbert, Biologia dello sviluppo. Zanichelli; J. M. W. Slack, Fondamenti di Biologia dello sviluppo, Zanichelli; Le Moigne-Foucrier, Biologia dello Sviluyppo, EdiSES
M.M. Altamura, S. Biondi, L. Colombo, F. Guzzo. Elementi di Biologia dello sviluppo delle piante Ed. Edises,
Lecture notes and slides
Review papers on specific subjects will be provided by the teacher


Prerequisites and examination procedures written exam
Teaching Methods lectures


Language of instruction
Italian


Recommended Prerequisites
Cell biology, Plant Biology and Systematic
BIO/01 - GENERAL BOTANY - University credits: 0
BIO/06 - COMPARATIVE ANATOMY AND CYTOLOGY - University credits: 0
Lessons: 48 hours

M - Z

Responsible
Lesson period
First semester
Course syllabus
Animal Developmental Biology:
An introduction to Developmental Biology: from egg to embryo. Cellular and molecular techniques for the study of development. Egg and sperm cells: structure of gametes and gametogenesis. Fertilization: species-specific interaction, cellular and molecular mechanisms regulating sperm-egg interaction. Embryonic development: maternal inheritance, cleavage, gastrulation and outlines of organogenesis. The three germ layers: ectoderm, mesoderm and endoderm. Morphogenesis of the Central Nervous System. Regeneration.
Animal models: Drosophila, Zebrafish, Xenopus, Chick and Mouse. Embryonic axes: the lesson from the Drosophila embryo.
The paradigm of differential gene expression. Homeobox genes and body plan. Stem Cells.
Introduction to plant development: differences between animal and plant development. Model system in plant. Embryo development, meristems organization, flower development. Hormonal control of differentiation.

Plant Developmental biology:
- comparison betwennn plant and animal developmental
- model plant organisms
- i meccanismi di differenziamento: asymmetric divisions, gradients, transcriptional regulation
- morphogens and embriool,ogy
- the apical meristem
- the radical meristem
-axillary meristems and lateral organs
- plant-environment
- organogenesis in root and flowers


Tutorials
Gilbert SF Developmental Biology Sinauer Ass ed. 8° Editino 2006
Altamura et al., Elementi di Biologia dello Sviluppo delle piante Edises


Reference Material
The supporting materials of each teaching line, including papers and slides will be available at the course web-page: http://ariel.unimi.it/


Prerequisites and examination procedures
Written tests with open questions


Teaching Methods
Traditional (lectures)


Language of instruction
Italian


Recommended Prerequisites
Cytology and histology, molecular biology genetics


Program information
web-page: http://ariel.unimi.it/
BIO/01 - GENERAL BOTANY - University credits: 0
BIO/06 - COMPARATIVE ANATOMY AND CYTOLOGY - University credits: 0
Lessons: 48 hours
Professor(s)
Reception:
On appointment (email)
Torre C 7th floor