Synthetic methods in biotechnology

A.Y. 2016/2017
Overall hours
Learning objectives
The course aims to provide students with the elements to understand and evaluate some modern chemical technologies applied to biotechnological processes, at the same time providing the basics of chemistry useful in understanding these technologies.
Expected learning outcomes
Course syllabus and organization

Single session

Lesson period
Second semester
Course syllabus
The program is divided into five modules, all dealing with advanced synthetic methodologies useful in biotechnology. A first model deals with protective groups in organic synthesis, and is preparing the student to the second module - solid-phase synthesis. The third module deals with the identification, isolation, dereplication and structural determination of natural products from prokaryots, lower and higher eukaryots; the use of natural products in pharmaceutical research, and their usefulness as core scaffolds for the synthesis of natural products-inspired combinatorial libraries is also covered. The fourth module deals with methodologies and principles for the rational design of biologically active molecules, while the last module covers the research process used in drug discovery - target identification and validation, lead discovery and lead optimization.

Reference material
All material presented in the course and various articles and reviews related to it, can be found on the website ARIEL the course.

Assessment methods: written and oral
The exam can be taken in written form (for those who have attended the course assiduously, in appeals immediately following the end of the course). Alternatively, the exam can be taken orally in the following sessions. In any case, the candidate must to answer 1-2 questions - written or oral - on each of the 5 modules of the course itself. The total score will be calculated partially by attributing a rating to each answer - written or oral -, and averaging algebraic weight of 20% each of the five modules.

Suggested prerequisites
Organic Chemistry I and II

Language of instruction

Other information
Attendance: strongly recommended
Type of course: traditional
CHIM/06 - ORGANIC CHEMISTRY - University credits: 6
Lessons: 48 hours
Professor: Seneci Pierfausto