Animal genetics and selection

A.Y. 2017/2018
10
Max ECTS
104
Overall hours
SSD
AGR/17
Language
Italian
Learning objectives
Fornire le conoscenze di base della genetica animale e della etnografia zootecnica, e i principi del miglioramento genetico nelle principali specie di interesse zootecnico, a livello sia teorico che applicato alla gestione delle popolazioni e degli allevamenti.
Expected learning outcomes
Undefined
Course syllabus and organization

Single session

Responsible
Lesson period
First semester
ATTENDING STUDENTS
Unita' didattica: Genetica di base
Course syllabus
BASIC GENETICS
The module aims to provide students with a basic understanding of animal genetics and is preparatory to the module/course of animal breeding. The module also aims to provide some elements of molecular genetics useful to the understanding of some solutions that DNA techniques offer to the selection and production.

STRUCTURE OF THE MODULE:
Lectures 24 hours 3CFU

Resuming concepts of euploidia, cell cycle, mitosis, meiosis and cell differentiation. Architecture of genomic and mitochondrial DNA, transcription, the genetic code, translation, RNA interfering, (2 hours)

Karyotype, speciation and genetic variability, homology, transmission of characters.
Concepts of locus, gene, gene mutation, alleles, SNP and genetic polymorphism, genotype, phenotype, homozygosity and heterozygosity. (4 hours)

Mendelian genetics with examples of transmission in different species of phenotypic traits. (4 hours)

Exceptions to Mendelian genetics (codominance, intermediate dominance, gender affected and limited characters, X-linked characters and genes, lethal genes). Family Tree analysis (4 hours)

Concepts of interaction, epistasis, pleiotropy, expressivity, penetrance, prevalence, and brief overview of epigenetic (genomic imprinting, methylation, acetylation, gene silencing). (4 hours)

Quantitative traits and heritability (definition, range, examples).
Calculating phenotype, genotype, allele frequency. What is a private allele
Molecular markers (microsatellites, SNPs and genetic profile) and their application for paterentage control, diagnosis of inherited diseases and genomic selection. Concepts of linkage, linkage disequilibrium and haplotype (6 hours)

Practice 16 hours 1CFU
Class exercises of classical genetics.
Practical demonstrations of: extraction of gDNA animal, PCR and agarose gel electrophoresis, fragment analysis and nucleotide sequencing
Unita' didattica: Zootecnica generale e principi di selezione
Course syllabus
DIDATICS
Specie and breed concepts. Main breeds of livestock: origin, physical characteristics, aptitude, yields (4 hours)
Breed organization and management, herdbook ana anagraphic register (1 hour)
The selected traits in the different species. Performkance recording (3 hours)
Qualiatative and quantitative traits (2 hours)
Infinitesimal model (2 hours)
Phenotype adjustment (2 hours)
Genetic parameters: heritability, repeatability, correlations (2 hours)

PRACTICE
Exercises and updating about the main topics developed in class lessons
Unita' didattica: Gestione genetica e miglioramento delle popolazioni
Course syllabus
Lectures

Principles of population genetics: genes and populations: Genotype and gene frequencies ; Hardy‐Weinberg law; Effects of selection, migation, mutation and genetic drift on gene freqeuncies (2 hrs.);
Kinship and inbreeding; computation from genealogies and genetic markers; Risks associated to high inbreeding; Population effective size and inbreeding rates (2 hrs.)
The selection index and its accuracy I momenti della selezione; dal fenotipo aggiustato all'indice genetico ; accuratezza dell'indice (2 hrs.);
Selection response; Progeny, Sib and Performance tests; Selection and inbreeding control (2 hrs.)
Genetic improvement in livestock populations in Italy: seminars in collaboration with the course "Zootecnica generale e principi di selezione" (4 hrs.)
Biodiversity, animal genetic resources conservation and valorization (2 hrs. )
Principles of genomic selection (2 hrs.)


Practice

Genotype and gene frequencies ; Hardy‐Weinberg law; Effects of selection, migation, mutation and genetic drift on gene freqeuncies (3 hrs.);
Kinship and inbreeding, computation from genealogies and from genetic markers; Population effective size (4 hrs.);
The selection index and its accuracy (5 hrs.);
Selection response (4 hrs.);
NON-ATTENDING STUDENTS
Unita' didattica: Genetica di base
Course syllabus
BASIC GENETICS
The module aims to provide students with a basic understanding of animal genetics and is preparatory to the module/course of animal breeding. The module also aims to provide some elements of molecular genetics useful to the understanding of some solutions that DNA techniques offer to the selection and production.

STRUCTURE OF THE MODULE:
Lectures 24 hours 3CFU

Resuming concepts of euploidia, cell cycle, mitosis, meiosis and cell differentiation. Architecture of genomic and mitochondrial DNA, transcription, the genetic code, translation, RNA interfering, (2 hours)

Karyotype, speciation and genetic variability, homology, transmission of characters.
Concepts of locus, gene, gene mutation, alleles, SNP and genetic polymorphism, genotype, phenotype, homozygosity and heterozygosity. (4 hours)

Mendelian genetics with examples of transmission in different species of phenotypic traits. (4 hours)

Exceptions to Mendelian genetics (codominance, intermediate dominance, gender affected and limited characters, X-linked characters and genes, lethal genes). Family Tree analysis (4 hours)

Concepts of interaction, epistasis, pleiotropy, expressivity, penetrance, prevalence, and brief overview of epigenetic (genomic imprinting, methylation, acetylation, gene silencing). (4 hours)

Quantitative traits and heritability (definition, range, examples).
Calculating phenotype, genotype, allele frequency. What is a private allele
Molecular markers (microsatellites, SNPs and genetic profile) and their application for paterentage control, diagnosis of inherited diseases and genomic selection. Concepts of linkage, linkage disequilibrium and haplotype (6 hours)

Practice 16 hours 1CFU
Class exercises of classical genetics.
Practical demonstrations of: extraction of gDNA animal, PCR and agarose gel electrophoresis, fragment analysis and nucleotide sequencing
Unita' didattica: Zootecnica generale e principi di selezione
Course syllabus
The course program is the same as described for attending students
Unita' didattica: Gestione genetica e miglioramento delle popolazioni
Course syllabus
The course program is the same as described for attending students
Unita' didattica: Genetica di base
AGR/17 - LIVESTOCK SYSTEMS, ANIMAL BREEDING AND GENETICS - University credits: 4
Practicals: 16 hours
Lessons: 24 hours
Professor: Longeri Maria Lina
Unita' didattica: Gestione genetica e miglioramento delle popolazioni
AGR/17 - LIVESTOCK SYSTEMS, ANIMAL BREEDING AND GENETICS - University credits: 3
Practicals: 16 hours
Lessons: 16 hours
Professor: Gandini Gustavo
Unita' didattica: Zootecnica generale e principi di selezione
AGR/17 - LIVESTOCK SYSTEMS, ANIMAL BREEDING AND GENETICS - University credits: 3
Practicals: 16 hours
Lessons: 16 hours
Professor: Rizzi Rita Maria