The course aims to provide the student with a good knowledge of the main industrial sectors where synthetic organic chemistry is relevant. Some meaningful examples are presented and thoroughly discussed during the theoretical part of the course. Several intermediates and compounds with industrial relevance will be prepared and characterized during the experimental/laboratory module.
The students will take advantage of this course, as i twill provide a general overview of the industrial applications of synthetic organic chemistry. Among the five selected industrial applications dealt with in the theoretical course (pharma, agro, catalysis, renewable energies and nanotech), the student will get information about modern trends for each sector, and will become ready to consider each of them for his/her future working experiences.
Ist Module (Prof. Pierfausto Seneci)
Applied Organic Chemistry - theoretical (6 CFU, 48 hours)
Course content [required]
Pharmaceutical research - 24 hours: identification of a target, discovery of hits and leads, structural optimization of active leads, synthetic strategies on a large scale. Identification of kinesins as anticancer targets through chemical genetics, development of MK-731 as an anticancer compound. Identification of kinase inhibitors using fragment-based drug discovery, development of AT519 as an antitumor compound. Discovery of statins as drugs against hypercholesterolemia, development and commercialization of fluvastatin-LescolTM. Discovery of beta-lactams and cephalosporins, industrial synthesis of ceftibuten. Agro research - 6 hours: herbicides, fungicides and insecticides. Field use, industrial and environmental issues. Rational design and synthesis of neonicotinoid insecticides, development and commercialization of imidacloprid. Homogeneous, heterogeneous, and bio-catalysis - 6 hours. Guiding principles in the design of new catalysts. Monsanto process for the synthesis of L-DOPA. DIPAMP, DuPHOS and BINAP in asymmetric reductions. Energy and Environment - 6 hours: renewable energy, greenhouse effect, carbon sources. Methanol fuel cells, dye-sensitized solar cells. Complexes of Ru and organic ligands as dye-sensitizers. Nanotechnology - 6 hours: definitions, physical and chemical phenomena at the nano-scale, industrial applications. Fullerenes, carbon nanotubes and graphene: synthesis using physical and organic-chemical methods, covalent and noncovalent functionalization, properties.
IInd Module (Prof. Dario Perdicchia)
Applied Organic Chemistry - laboratory (3 CFU, 24 hours)
The laboratory experiences will include the synthesis of organic molecules useful for industrial applications, their purification and characterization using simple analytical techniques.
Organic Chemistry I and II
The material presented during the course is made available to students on the course's ARIEL site.
Theoretical part: written, 3 intermediate essays, during the course or immediately after (up to September). Final vote, theoretical, results from the avg mark in pharma (40%), agro, catalysis, renewable energies and nanotech (15% each).
Laboratory part: written, depending on a final Report of performed activities, provided to the teacher after the lab experiences, including theory (description of reactions, explanation of findings) and experimental results (yields, analytical characterizations).
Overall mark: obtained as an average between theoretical (66.6%) and lab mark (33,3%).
Language of instruction
Strongly suggested (theoretical)
Mode of teaching