Developmental biology

A.Y. 2017/2018
6
Max ECTS
48
Overall hours
SSD
BIO/01 BIO/06
Language
Italian
Learning objectives
The course will introduce the student to the most important aspects of the developmental Biology and to the most significative model organisms employed in developmental studies. The course will also discuss the use of mutants and the most important techniques daily used by the researchers in this field.
Expected learning outcomes
Undefined
Course syllabus and organization

Edizione A - L

Responsible
Lesson period
First semester
Course syllabus
Animal developmental biology:
- From fertilized egg to the individual: developmental genetic and epigenetic program.
- Tissue differentiation and stem cells.
- Animal models used in developmental biology.
- Fertilization.
- Developmental phases: segmentation, gastrulation, organogenesis, morphogenesis.
- Body axis formation: antero-posterior and dorso-ventral development.
- Induction: insights on embryonic cell-cell communication.
- Vertebrate limb development.
- Experimental embryology: normal and abnormal development.

Plant developmental biology:
- Differences and similarities between plant and animal development
- Plant model systems
- Developmental drivers: asymmetric cell division, morphogenic gradients and transcriptional regulation
- Embryo development
- Development and maintenance of the shoot apical meristem
- Development of the root apical meristem
- Positioning of lateral organs on the main stem and acquisition of leaf identity and polarity
- Floral transition in response to seasonal cues (cold and photoperiod)
- Flower development


Reference Material
S.F. Gilbert, Biologia dello sviluppo. Zanichelli; J. M. W. Slack, Fondamenti di Biologia dello sviluppo, Zanichelli; Le Moigne-Foucrier, Biologia dello Sviluyppo, EdiSES
M.M. Altamura, S. Biondi, L. Colombo, F. Guzzo. Elementi di Biologia dello sviluppo delle piante Ed. Edises, lecture notes and slides, review papers on specific subjects will be provided by the teacher.


Prerequisites and examination procedures
Written exam with open questions related to both Animal and Plant Developmental Biology. Both sections need to be completed.


Teaching Methods
Lectures


Language of instruction
Italian


Recommended Prerequisites
Cell biology, Plant Biology and Systematic
BIO/01 - GENERAL BOTANY - University credits: 0
BIO/06 - COMPARATIVE ANATOMY AND CYTOLOGY - University credits: 0
Lessons: 48 hours

Edizione M - Z

Responsible
Lesson period
First semester
Course syllabus
Animal Developmental Biology:
An introduction to Developmental Biology: from egg to embryo. Cellular and molecular techniques for the study of development. Egg and sperm cells: structure of gametes and gametogenesis. Fertilization: species-specific interaction, cellular and molecular mechanisms regulating sperm-egg interaction. Embryonic development: maternal inheritance, cleavage, gastrulation and outlines of organogenesis. The three germ layers: ectoderm, mesoderm and endoderm. Morphogenesis of the Central Nervous System. Regeneration.
Animal models: Drosophila, Zebrafish, Xenopus, Chick and Mouse. Embryonic axes: the lesson from the Drosophila embryo.
The paradigm of differential gene expression. Homeobox genes and body plan. Stem Cells. Medical Embryology.

Plant Developmental biology:
- comparison between plant and animal developmental
- model plant organisms
- mechanisms for differentiation: asymmetric cell divisions, morphogen gradients, transcriptional regulation
- morphogens and embryology
- the apical meristem
- the radical meristem
-axillary meristems and lateral organs
- plant-environment interactions
- organogenesis in root and flowers


Tutorials
Gilbert SF Developmental Biology Sinauer Ass ed. 8° Editino 2006
Altamura et al., Elementi di Biologia dello Sviluppo delle piante Edises


Reference Material
The supporting materials of each teaching line, including papers and slides will be available at the course web-page: http://ariel.unimi.


Prerequisites and examination procedures
Written tests with open questions


Teaching Methods
Traditional (lectures)


Language of instruction
Italian


Recommended Prerequisites
Cytology and histology, molecular biology gentics


Program information web-page: http://ariel.unimi
BIO/01 - GENERAL BOTANY - University credits: 0
BIO/06 - COMPARATIVE ANATOMY AND CYTOLOGY - University credits: 0
Lessons: 48 hours
Professor(s)
Reception:
On appointment (email)
Torre C 7th floor