1. The Pharmacology of Food Nutraceuticals as therapeutic agents Cocoa components and their potential benefits for human health Cocoa polyphenols: action in cardiovascular disease, anti-inflammatory properties, action in cancer. Theobromine. Anandamide in chocolate: a debate. Resveratrol in red wine Effects of resveratrol on endothelial and cardiovascular function (NO, mitochondrial biogenesis, endothelial senescence and activation, effect on endothelial progenitor cells, endothelin, cholestreol efflux and anti-inflammatory properties). Beneficial effects of resveratrol on atherosclerosis. Resveratrol and cancer. Neuroprotective properties of resveratrol in neurodegenerative disorders (Alzheimer's Disease, Huntington's Disease, and Amyotrophic Lateral Sclerosis). Resveratrol and longevity. Resveratrol, obesity and diabetes. Resveratrol and osteoporosis. Absorption, bioavailability, and metabolism of resveratrol. Drug interactions. Green tea Epigallocatechin-3-gallate and its role in cardiovascular diseases, atherosclerosis, cancer, neurodegenerative disorders. Weight control and prevention of metabolic syndrome by green tea.
2. Food toxicology Introduction to toxicology Embryotoxic agents Alcohol abuse in pregnant women: molecular aspects of the actions of alcohol on the developing brain (alterations in gene expression regulation and homeobox genes, interference with growth factors, epigenetic alterations, adhesion molecules and oxidative stress, apoptosis, derangements in glial proliferation and functioning). Actions of alcohol on the adult brain (excitotoxicity, inflammation and gene expression). Food additives and contaminants Biotechnology and Genetically Modified Organisms (GMO) GMO and nutrition: risks and benefits.
Tutorials ppt presentation and videos
Reference Material Scientific articles and reviews
Prerequisites and examination procedures Students are expected to have basic knowledge of pharmacology. Oral examination.
Teaching Methods Traditional frontal lesson
Language of instruction Italian
Recommended Prerequisites none
Program information Ppt files and scientific articles will be available on Ariel 2.0 WebSite