To provide the student with the basic tools necessary to tackle and solve problems of introductory organic chemistry.
In particular: presentation of nomenclature, physical chemical properties of organic compounds and reactivity of functional groups, C-C bond formation basic reactions; development of a rational approach to the organic synthesis through the disconnection methodology; description of the concepts of chemio- and stereoselective reactions.
The student will be able to:
give the correct name to an organic molecule; individuate the functional groups and stereogenic elements of an organic compound;
use and convert functional groups, also through oxidation and reduction reactions;
know the basic reactivity of organic molecules and the fundamental reactions for C-C bond formation;
tackle the synthesis of simple, functionalized molecules, by exploiting the principles of the retro-synthetic approach.
This course aims at providing the student with the knowledge required to tackle all the fundamental problems of organic chemistry, with particular emphasis focussed on the study and the understanding of the chemical properties and reactivity of aliphatic compounds.
In the theory part of the course the concepts of chemical bonding and atom ibridization will be briefly summarized, followed by an introduction to stereochemistry and conformational analysis (10 hours).
Then, the standard classification of organic compounds on the basis of their reactivity deriving from the presence of functional groups will be presented in the following sequence: alkanes, haloalkanes, alchools, thiols, amines, alkenes, alkynes, polyenes, allylic and other delocalized systems (12 hours).
Carbonyl compounds and their reactivity (10 hours).
Carboxylic acids and their derivatives (12 hours).
Retrosynthetic analysis (4 hours).
With the in-class exercises (16 hours) the student will be trained in solving simple problems of organic chemistry and of retro-synthetic analysis of relatively complex structures.
Basic knowledge of general and inorganic chemistry
Brown, Foote, Iverson, Anslyn: Organic Chemistry V Ed., Thomson Learning, Inc., Glendale, CA, USA.
Written and oral examination: the written tesxt will include problems related to all the topics discussed in the course; after passing the written exam, the student will take an oral examination that involves the discussion on the synthesis of an organic molecule on the blackboard and, possibly, some questions on the theory (reaction mechanisms, characteristics and properties of organic molecules and reagents).
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