Pathogenetic basis of diseases

A.Y. 2017/2018
Overall hours
MED/04 MED/09
Learning objectives
The course aims to develop knowledge on the pathogenic basis of human diseases, with particular attention to limits and benefits of the main experimental models available and their correlation with clinical presentation of the disease. It is based on a series of lectures grouped on thematic sections and focusing on pathogenic mechanisms and experimental approaches. The course also includes two journal club sessions held by the students on selected scientific articles proposed by the Faculty, aimed at developing the student's ability to critical reading, presentation, and discussion of the scientific data.
Expected learning outcomes
Students will acquire an integrated comprehension of the pathogenic basis of human pathology and on the correlation of pathogenic mechanisms and clinical manifestations. They will also acquire information on potentials and limitations of experimental models available. The journal club sessions will allow them to develop critical reading, presentation, and scientific data discussion abilities
Course syllabus and organization

Single session

Lesson period
First trimester
General pathology and immunology
Course syllabus
Immunomediated diseases
Pathogenic mechanisms in allergic diseases
Pathogenic mechanisms in primary and acquired immunodeficiencies
The inflammasome and autoinflammatory syndromes
Inflammation resolution: molecular mechanisms and experimental models
Transplantation immunology
The graft versus host disease: experimental models and implications for bone marrow transplant
Role of the immune response in liver transplant rejection
Role of microbiota on immune response and autoimmune diseases

Immunity and cancer: Role of adaptive immunity in cancer
Inflammation and cancer: intrinsic and extrisic inflammation in cancer promotion
Inflammation and cancer in experimental models
Ovary carcinoma: clinical presentation and experimental models
Molecular phenotypes of mammary carcinoma: clinical presentations and experimental models
In vivo imaging techniques (CT, MRI, PET, SPECT, ultrasound)
Optical in vivo imaging
Metastasis experimental models and their visualization in vivo

Infectious diseases
Pathogen recognition and septic shock
Immunothrombosis: hemostasis and innate immunity interplay
Soluble pathogen recognition receptors in infectious models
Immune escape mechanisms in experimental infectious models
Internal medicine
Course syllabus
Iron metabolism and erythropoiesis:
The anemias;
Iron overload disorders;
Iron metabolism and hereditary hemochromatosis

Metabolic diseases:
The metabolic syndrome and type 2 diabetes;
Experimental models of insulin resistance and nonalcoholic fatty liver disease;
Pathophysiology and genetics of a complex disease: nonalcoholic steatohepatitis.

Liver and kidney disease
Liver diseases and hepatocellular carcinoma
Human genetics and models of metabolic diseases
Kidney diseases
Experimental models for study the life cycle and therapeutic approaches to hepatitis C virus infection

Diseases of cardiovascular system: the crosstalk between haemostasis, immune and inflammatory response, and damage repair:
Thrombosis, thrombogenesis and thrombotic diseases;
Aterosclerosis and arterial thrombosis: coronary heart disease and ischemic cerebrovascular disease;
Venous thromboembolism;
Heart remodeling in systemic hypertension, heart failure, coronary heart disease, and atrial fibrillation;
Seminar: Modeling biologic systems: network based simulation for translational medicine: an application to anticoagulation;
Antithrombotic pharmacological and non-pharmacological therapy.

Aging and age-related diseases between genetics, epigenetics and enviromental noxae:
Seminar: Cerebral aging and neurodegenerative diseases. Alzheimer disease and biomarkers;
Inflammaging, immune senescence and premature lung aging in the pathogenesis of respiratory diseases: COPD and interstitial lung diseases.
General pathology and immunology
Lessons: 42 hours
Professors: Balsari Andrea, Locati Massimo, Marchesi Federica, Sfondrini Lucia
Internal medicine
MED/09 - INTERNAL MEDICINE - University credits: 6
Lessons: 42 hours
by appointment (e-mail request)
Marangoni pavilion, Policlinico IRCCS hospital, via F Sforza 35, Milan