Physics protein 1
A.Y. 2017/2018
Learning objectives
In the course we shall discuss the physical principles that control the kinetic and the equilibrium properties of proteins from the perspective of statistical mechanics.
Expected learning outcomes
Undefined
Lesson period: First semester (In case of multiple editions, please check the period, as it may vary)
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Course syllabus and organization
Single session
Responsible
Lesson period
First semester
Course syllabus
- What proteins are; the thermodynamic hypothesis.
- Review of the main experimental results on proteins
- Phase transitions in proteins
- The beta-hairpin transition
- The protein folding phase transition
- The helix-coil transition
- Interactions among amino acids
- The hydrophobic force
- Polymer theory: the ideal chain, freely-rotating chain, torsional energy
- Interacting polymer: the Virial expansion, coil, theta point, globules, coil-globule transition
- Disordered interactions; the random energy model
- The energy landscape: replica calculations
- Proteins as result of evolution
- Dynamics: Langevin equations, stochastic differential equations and Brownian motion
- The Rouse chain
- The Fokker-Planck equation
- Jumping energy barriers: Kramers equation
- Stochastic processes, detailed balance, kinetics models for proteins
- Dimensional reduction
- Protein aggregation
- Review of the main experimental results on proteins
- Phase transitions in proteins
- The beta-hairpin transition
- The protein folding phase transition
- The helix-coil transition
- Interactions among amino acids
- The hydrophobic force
- Polymer theory: the ideal chain, freely-rotating chain, torsional energy
- Interacting polymer: the Virial expansion, coil, theta point, globules, coil-globule transition
- Disordered interactions; the random energy model
- The energy landscape: replica calculations
- Proteins as result of evolution
- Dynamics: Langevin equations, stochastic differential equations and Brownian motion
- The Rouse chain
- The Fokker-Planck equation
- Jumping energy barriers: Kramers equation
- Stochastic processes, detailed balance, kinetics models for proteins
- Dimensional reduction
- Protein aggregation
Professor(s)