Physics protein 1

A.Y. 2018/2019
6
Max ECTS
42
Overall hours
SSD
FIS/03
Language
Italian
Learning objectives
In the course we shall discuss the physical principles that control the kinetic and the equilibrium properties of proteins from the perspective of statistical mechanics.
Expected learning outcomes
Undefined
Course syllabus and organization

Single session

Responsible
Lesson period
First semester
Course syllabus
- What proteins are; the thermodynamic hypothesis.
- Review of the main experimental results on proteins
- Phase transitions in proteins
- The beta-hairpin transition
- The protein folding phase transition
- The helix-coil transition
- Interactions among amino acids
- The hydrophobic force
- Polymer theory: the ideal chain, freely-rotating chain, torsional energy
- Interacting polymer: the Virial expansion, coil, theta point, globules, coil-globule transition
- Disordered interactions; the random energy model
- The energy landscape: replica calculations
- Proteins as result of evolution
- Dynamics: Langevin equations, stochastic differential equations and Brownian motion
- The Rouse chain
- The Fokker-Planck equation
- Jumping energy barriers: Kramers equation
- Stochastic processes, detailed balance, kinetics models for proteins
- Dimensional reduction
- Protein aggregation
FIS/03 - PHYSICS OF MATTER - University credits: 6
Lessons: 42 hours
Professor: Tiana Guido
Professor(s)
Reception:
Friday, h. 11-13