Synthetic methods in biotechnology

A.Y. 2018/2019
6
Max ECTS
48
Overall hours
SSD
CHIM/06
Language
English
Learning objectives
The course aims to provide the student with elements to understand and evaluate several modern chemical technologies applied to biotechnological and pharmaceutical processes, meanwhile providing also the basic theoretical notions to understand the nature and the impact of such technologies.
Expected learning outcomes
The students will take advantage of this course, by gathering a general perspective regarding the role of synthetic organic chemistry in biotechnological and pharmaceutical research. Among the five selected applications dealt with in the course (protective groups, solid-phase synthesis, combichem & natural products, rational design in drug discovery and phases of pharma research), the student will get information about modern trends for each application, and will become knowledgeable about their scope, their advantages and their limitations.
Course syllabus and organization

Single session

Responsible
Lesson period
Second semester
Course syllabus
Goals
The course aims to provide the student with elements to understand and evaluate several modern chemical technologies applied to biotechnological and pharmaceutical processes, meanwhile providing also the basic theoretical notions to understand the nature and the impact of such technologies.


The students will take advantage of this course, by gathering a general perspective regarding the role of synthetic organic chemistry in biotechnological and pharmaceutical research. Among the five selected applications dealt with in the course (protective groups, solid-phase synthesis, combichem & natural products, rational design in drug discovery and phases of pharma research), the student will get information about modern trends for each application, and will become knowledgeable about their scope, their advantages and their limitations.


Course content
The program is divided into five modules, all dealing with advanced synthetic methodologies useful in biotechnology. A first model deals with protective groups in organic synthesis, and is preparing the student to the second module - solid-phase synthesis. The third module deals with the identification, isolation, dereplication and structural determination of natural products from prokaryots, lower and higher eukaryots; the use of natural products in pharmaceutical research, and their usefulness as core scaffolds for the synthesis of natural products-inspired combinatorial libraries is also covered. The fourth module deals with methodologies and principles for the rational design of biologically active molecules, while the last module covers the research process used in drug discovery - target identification and validation, lead discovery and lead optimization.


Suggested prerequisites
Organic Chemistry I and II


Reference material
The material presented during the course is made available to students on the course's ARIEL site.


Assessment method
Written (three essays during the course, 33% influence on final vote; or a written full exam/essay), until September. Alternatively, oral (later than September).

Language of instruction
English

Attendance Policy
Strongly suggested

Mode of teaching
Traditional

Website
https://ariel.unimi.it
CHIM/06 - ORGANIC CHEMISTRY - University credits: 6
Lessons: 48 hours
Professor: Seneci Pierfausto
Professor(s)