Toxicology

A.Y. 2018/2019
8
Max ECTS
64
Overall hours
SSD
BIO/14
Language
Italian
Learning objectives
- Caratterizzare le manifestazioni e i meccanismi di tossicità
- Fornire basi scientifiche della Tossicologia sperimentale ed i criteri di valutazione ed estrapolazione all'uomo dei dati di tossicità
- Fornire adeguate conoscenze tossicologiche e valide basi per la definizione dei criteri di protezione della salute dell'uomo dai rischi derivanti dall'assunzione diretta (medicamenti, additivi alimentari, ecc.) o indiretta (inquinanti ambientali, solventi industriali, ecc.) di agenti chimici, fisici e biologici.
Expected learning outcomes
Undefined
Course syllabus and organization

Linea AK

Responsible
Lesson period
Second semester
Course syllabus
· Principles of Toxicology
· Understanding of the concepts of general pharmacology applied to toxicology (relationship dose-effect, risk, local and systemic effects, secondary effects, and toxic effects of drugs and other xenobiotics.
· Toxicokinetics and Toxicodynamics
· Concepts related to the absorption and the biotransformation of drugs and other xenobiotics and their elimination.
· Molecular mechanisms of toxicity
· Understanding of the primary mechanisms of cellular toxicity, definition of apoptosis and necrosis and markers of cellular damage.
· Relevant classes of toxicants (metals, natural toxins, pesticides, solvents, etc..)
· Main systems and target organs of toxic substances (including the effects of genotoxicants, carcinogens and teratogens)
· Pre-Clinical experiments and main toxicological tests
· Diet-drugs interactions
· Concept of human risk
· Definition of the protection criteria of human health from the risk deriving from the direct intake (drugs, food additives, etc.) or indirect intake (environmental pollution, industrial solvents, etc.) of chemical and biological substances.
BIO/14 - PHARMACOLOGY - University credits: 8
Lessons: 64 hours
Professor: Viviani Barbara

Linea LZ

Responsible
Lesson period
Second semester
Course syllabus
· Principles of Toxicology
· Understanding of the concepts of general pharmacology applied to toxicology (relationship dose-effect, risk, local and systemic effects, secondary effects, and toxic effects of drugs and other xenobiotics.
· Toxicokinetics and Toxicodynamics
· Concepts related to the absorption and the biotransformation of drugs and other xenobiotics and their elimination.
· Molecular mechanisms of toxicity
· Understanding of the primary mechanisms of cellular toxicity, definition of apoptosis and necrosis and markers of cellular damage.
· Relevant classes of toxicants (metals, natural toxins, pesticides, solvents, etc..)
· Main systems and target organs of toxic substances (including the effects of genotoxicants, carcinogens and teratogens)
· Pre-Clinical experiments and main toxicological tests
· Diet-drugs interactions
· Concept of human risk
· Definition of the protection criteria of human health from the risk deriving from the direct intake (drugs, food additives, etc.) or indirect intake (environmental pollution, industrial solvents, etc.) of chemical and biological substances.
BIO/14 - PHARMACOLOGY - University credits: 8
Lessons: 64 hours
Professor: Marinovich Marina