System medicine

Dottorati
Doctoral programme (PhD)
A.Y. 2020/2021
Study area
Medicine and Healthcare
Inter-university
Università degli Studi di Napoli Federico II
Doctoral programme (PhD)
4
Years
Dipartimento di Oncologia ed Emato-Oncologia - Via Festa del Perdono, 7 - Milano
English
PhD Coordinator
The Medicine field is going through a cultural revolution, pressed by the new knowledge emerging from the fundamental biology (molecular biology, and, more recently, genomics). This knowledge has brought to the development of the Personalized Medicine, based on the identification of the mechanisms in the disease, specific to the given disease and to the patient, and the consequent molecular treatments. Although the Personalized Medicine changed the story of some diseases, for some others there exists a rising discrepancy between the scientific discoveries and their turning into a benefit for the patient. This discrepancy is considered a problem by both the scientific community and the society. The aim of the PhD course is the training of a new generation of basic researchers, able to follow the changes occurring in the biomedicine.

The fundamental elements of the training program are:

· the introduction of basic subjects (mathematics, physics, informatics, statistics);
· the teaching of new models of Translational Research, where the basic researchers work along with the clinicians on the same biomedical problems;
· the foundation of a humanistic culture of the new scientific discoveries (foundational, ethical and sociological basis) and the operative tools (cognitive sciences) which allow the new scientists to interact with the society (patients, policy-makers).
Tutte le classi di laurea magistrale - All classes of master's degree
Dipartimento di Oncologia ed Emato-Oncologia - Via Festa del Perdono, 7 - Milano
Title Professor(s)
Understanding the molecular role of tumor BRCA suppressor genes
Curriculum: Molecular Oncology
The role of DNA repair and DNA damage response proteins in vertebrate stem cells, embryonic development and cancer
Curriculum: Molecular Oncology
Molecular mechanisms ensuring genome stability altered in cancer and stem cells
Curriculum: Molecular Oncology
Metabolismo del DNA
Curriculum: Molecular Oncology
How organelle communication regulates EGFR endocytosis and signaling: relevance to physiology and cancer
Curriculum: Molecular Oncology
Endocytosis, signaling and cancer
Curriculum: Molecular Oncology
Role of Epsin3-mediated endocytosis in cell plasticity, breast cancer progression and metastasis
Curriculum: Molecular Oncology
Molecular and structural investigation of the p53 regulatory pathway mediated by the numb isoforms
Curriculum: Molecular Oncology
Upstream and downstream mechanisms linked to the loss of the tumor suppressive function of Numb in bladder carcinogenesis: therapeutic and clinical implications
Curriculum: Molecular Oncology
Upstream and downstream mechanisms linked to the loss of the tumor suppressive function of Numb in bladder carcinogenesis: therapeutic and clinical implications
Curriculum: Molecular Oncology
Shaping of iNKT cells cytotoxic functions during CRC progression
Curriculum: Molecular Oncology
F. Facciotti
Mucosal immunology
Curriculum: Molecular Oncology
F. Facciotti
Role of IL-10 producing regulatory T-cells in cancer
Curriculum: Molecular Oncology
Regulatory and helper T-cell subsets in health and disease
Curriculum: Molecular Oncology
Mechanisms controlling morphology of neural progenitor cells during brain development
Curriculum: Molecular Oncology
N. Kalebic
Molecular mechanisms underlying brain development and evolution
Curriculum: Molecular Oncology
N. Kalebic
Clonal tracking in vivo in melanoma patient-derived xenografts
Curriculum: Molecular Oncology
L. Lanfrancone
Modeling and Targeting Metastatic Cancer in vivo and in vitro
Curriculum: Molecular Oncology
L. Lanfrancone
Metabolic and epigenetic control of innate immunity in cancer
Curriculum: Molecular Oncology
L. Mazzarella
Predictors of response to combined immunological + epigenetic therapy
Curriculum: Computational Biology
L. Mazzarella
Machine learning-based methods for interpreting cancer-associated germline and somatic variants
Curriculum: Computational Biology
L. Mazzarella
Integration of transcriptional and metabolic control in inflammatory responses
Curriculum: Molecular Oncology
G. Natoli
Transcriptional Control in Inflammation and Cancer
Curriculum: Molecular Oncology
G. Natoli
Noncoding RNA Mechanisms involved in transcriptional and epigenetic plasticity of cancer cells
Curriculum: Molecular Oncology
F. Nicassio
Detection and quantification of RNA profiles and RNA modifications from Nanopore direct RNA sequencing data in human disease
Curriculum: Computational Biology
F. Nicassio
Noncoding Genome in Development and Disease
Curriculum: Computational Biology
F. Nicassio
Noncoding Elements and Transcriptional plasticity in advanced cancer
Curriculum: Molecular Oncology
F. Nicassio
Exploring molecular and cellular mechanisms of cancer progression and metastases
Curriculum: Molecular Oncology
Phenotypic and functional adaptation of cancer cells to the tumor microenvironment as a leading cause of metastatic dissemination
Curriculum: Molecular Oncology
Role of asymmetric/symmetric division in normal and cancer stem cells
Curriculum: Molecular Oncology
Analyses of the genetic and phenotypic evolution at single-cell level of normal and cancer stem cells
Curriculum: Computational Biology
EV-based liquid biopsy in Glioblastoma
Curriculum: Molecular Oncology
Multimodel approach on risk factors and management of cardiotoxicity in cancer patients
Curriculum: Medical Humanities
Clinical Decision Support system for data interpretation and shared decision-making in oncology
Curriculum: Medical Humanities
Modelling shared decision making in health care
Curriculum: Medical Humanities
Developing integrated health behavioural models to prevent cancer disease
Curriculum: Medical Humanities
Tumor ecosystem evolution
Curriculum: Computational Biology
M. Schaefer
Detection of causative cancer drivers beyond point mutations
Curriculum: Computational Biology
M. Schaefer
Microenvironmental exposure and tumor evolution
Curriculum: Computational Biology
M. Schaefer
Computational cancer biology
Curriculum: Computational Biology
M. Schaefer
Organoid-based single cell deconvolution of the health impact of endocrine disruptors
Curriculum: Molecular Oncology
Single-cell-omic deconvolution of druggable circuits in patient-derived ovarian cancer organoids
Curriculum: Molecular Oncology
Epigenetic dysregulation in Weaver syndrome: single-cell-omic deconvolution in patient-specific brain organoids
Curriculum: Molecular Oncology
Single-cell multi-omics deconvolution of neurodevelopmental disorders
Curriculum: Computational Biology
Stem Cell and Organoid Epigenetics
Curriculum: Molecular Oncology
Epigenetics of Weaver syndrome
Curriculum: Molecular Oncology
Solid-to-liquid-like transition during cancer progression
Curriculum: Molecular Oncology
Mechanisms of Tumor Cell Migration
Curriculum: Molecular Oncology
Structural and functional role of TFIIIC in genome architecture
Curriculum: Molecular Oncology
A. Vannini
Structural studies of protein complexes associated with intellectual disabilities and cancer
Curriculum: Molecular Oncology
A. Vannini
Study of Ezrin\TSC\mTORC1 pathway in retina: a new therapeutic target to treat retinal degeneration
Curriculum: Human Genetics
A. Auricchio
AAV-mediated genome editing for therapy of inherited blindness and of lysosomal storage diseases
Curriculum: Human Genetics
A. Auricchio
Gene Therapy of Severe Inherited Photoreceptor Diseases
Curriculum: Human Genetics
A. Auricchio
Elucidating the mechanisms underlying kidney cystogenesis and tumorigenesis
Curriculum: Human Genetics
A. Ballabio
Transcriptional regulation of autophagy and lysosomal function
Curriculum: Human Genetics
A. Ballabio
Development of novel therapies for inborn errors of metabolism
Curriculum: Human Genetics
N. Brunetti-Pierri
New therapies for inborn errors of metabolism
Curriculum: Human Genetics
N. Brunetti-Pierri
Cloud computing for high-throughput genomics applications
Curriculum: Human Genetics
D. Cacchiarelli
Genomic medicine
Curriculum: Human Genetics
D. Cacchiarelli
Understanding and treating neurodegeneration in lysosomal storage diseases
Curriculum: Human Genetics
A. Fraldi
Molecular Theraphy
Curriculum: Human Genetics
A. Fraldi
Investigation of the role of tmem175 in lysosomal and autophagic pathways
Curriculum: Human Genetics
D. Medina
Cell Biology and desease Mechanisms
Curriculum: Human Genetics
D. Medina
One gene several diseases: why and how?
Curriculum: Human Genetics
B. Franco
Can down regulation of miR181 be beneficial in Friedreich Ataxia?
Curriculum: Human Genetics
B. Franco
Cilia and Human Diseases
Curriculum: Human Genetics
B. Franco
Tracking the intracellular trafficking pathways of structural proteins of SARS-COVs
Curriculum: Human Genetics
A. De Matteis
Kidney Organoids for the Modeling of inherited renal diseases
Curriculum: Human Genetics
A. De Matteis
Signaling in membrane trafficking
Curriculum: Human Genetics
A. De Matteis
Role of ionocytes in the the physiology of the airway epithelium
Curriculum: Human Genetics
L. Galieta
Pharmacological modulation of ion transport to treat the basic defect in cystic fibrosis and other genetic diseases
Curriculum: Human Genetics
L. Galieta
Translational studies to impair breast cancer metabolism: a focus on TNBC
Curriculum: Molecular Oncology
M. Zollo

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