The course aims at providing students with the most important concepts, the knowledge of the basic principles and fundamentals related to nanoparticles and their applications.
The skills that are acquired by students at the end of the course consist in the knowledge of the methods of synthesis of inorganic nanoparticles and their functionalization for biomedical applications in the scientific discipline.
Part I, Daniela Maggioni Basic concepts on the nanoparticles, their physico-chemical properties and how these latter can be modulated changing nano particles size will be presented In particular, the synthetic procedures (using both top-down and bottom-up approaches) for the preparation of different nanoparticle classes (metallic, semiconductors and quantum dots) will be described. The peculiar properties of the different types of nanoparticles (absorption, emission, modulation of the nanosized semiconductors band gap etc.) will be described. Methods for the preparation of inorganic core/shell nanoparticles (like for example Au@SiO2, CoFe2O4@Au, Fe3O4@SiO2) will be described, as materials for biomedical uses as well as the techniques most commonly employed for their characterization in the solid state (TEM, SEM and AFM) and in suspension (DLS and Z-Potential). Some recent applications will be discussed. TOTAL 24 h.
Part II, Emanuela Licandro This part is mainly focused on superparamagnetic iron oxide nanoparticles such as maghemite and magnetite, for which fundamental principles are described. In particular, definitions, characteristics and potential applications are presented. In detail, magnetic characteristics, synthesis and stabilization methods are illustrated. Organic reactions useful for the functionalization of nanoparticles surface with organic molecules and biomolecules are presented. Basic principles of biomedical applications are also described: 1] in diagnostics, through the use of nanoparticles as contrast agents for magnetic resonance imaging and 2] in therapy, thanks to their ability to give hyperthermia, drug transport, vector fo cells uptake. In the last part of the course basic principles of Halloysite nanotubes are described, as innovative nanosystems for potential applications in diagnostics and therapy. TOTAL 24h