- Conoscere i principi della farmacodinamica, della farmacocinetica e le principali interazioni farmacologiche; - Conoscere le patologie umane rilevanti in ambito internistico e il loro approccio terapeutico; - Conoscere i meccanismi di azione e gli effetti collaterali delle principali classi di farmaci; - Conoscere i meccanismi di azione e gli effetti delle sostanze d'abuso; - Conoscere il concetto di farmaco-vigilanza.
Module program: General Pharmacology 1. Definition of Pharmacology 2. Pharmacodynamics - Drug Receptors - Agonists (full, partial, inverse) and antagonists (competitive and noncompetitive) - Drug-receptor interactions - affinity, intrinsic activity - The dose-response relationship(s) 3. Pharmacokinetics - Routes of administration of the drugs - Absorption, distribution metabolism and elimination of the drugs. - Plasma drug concentration as a function of time - Dose-response relationships - Efficacy, potency - Long-term effects of drugs (including tolerance and regulation of gene expression) 4. Principles of Pharmacogenetics and Pharmacogenomics 5. Development, Evaluation and Control of Drugs (including principles of Pharmacovigilance) 6. Clinical trials and placebo effect Special Pharmacology 1. The neurotransmission - Adrenergic and cholinergic neurotransmission - Dopaminergic neurotransmission - Serotoninergic neurotransmission - Histaminergic neurotransmission - GABA-ergic neurotransmission Drugs used to treat the diseases of the different organs and systems 2. Gastrointestinal system - Drugs used to treat peptic ulcer - Prokinetics, - Emetics and antiemetics, - Laxatives and anti-diarrheal drugs 3. Drugs used to treat diabetes mellitus (insulin and oral hypoglycemic agents) 4. Drugs used to regulate the fertility 5. Respiratory system - Drugs used to treat asthma, COPD and and allergic rhinitis - Anti cough drugs and mucolytics 6. Cardiovascular system - Antihypertensives - Antianginal drugs - Antiarrhythmics - Drugs used in heart failure - Drugs for blood disorders 7. Musculoskeletal system - Nonsteroidal anti-inflammatory drugs - Glucocorticoids 8. Central nervous system - Central analgesics - Anxiolytic - hypnotics - Antidepressants - Pain therapy - Drugs used in Parkinson's disease - Drugs used in Alzheimer's disease - Antipsychotic drugs - Anticonvulsants 9. Antimicrobial chemotherapy 10. General principles of cancer chemotherapy.
Module program: General pharmacology - What is it and what does it involve pharmacology - Drug / toxic Concept - Discovery and development of new drugs and research phases - Pharmacovigilance - Definition of pharmacodynamics and pharmacokinetics Pharmacodynamics - Receptor Concept - Receptor drug interaction: types of bonds - Efficiency, Power, dose-response curve - Therapeutic Index - Drugs agonists and antagonists - Antagonism competitive and non-competitive, chemical and functional - The four superfamilies of receptors, channels, linked to G proteins, enzymes, and intracellular signal transduction - Concept of receptor desensitization Pharmacokinetics - Routes of drug administration. - Pharmaceutical Preparations - Consumption of drugs - Distribution of medicines - Biotransformation of drugs - Elimination of drugs. - Main pharmacokinetic parameters. Individual variability in drug response - Placebo effect. Hypersensitivity. addiction Interactions between drugs and between drugs and foods. Special Pharmacology 1. Autonomic Nervous System sympathetic and parasympathetic system. Adrenergic and cholinergic neurotransmission agonists and antagonists that interfere with adrenergic transmission agonists and antagonists that interfere with cholinergic transmission Other Neurotransmission Systems to. dopaminergic b. serotonergic c. histaminergic d. GABAergic 2. Drugs used in diseases of the different apparatus and systems For each system: Major classes of drugs, mechanisms of action, pharmacokinetics, methods of therapeutic use, side / toxic effects Gastrointestinal system - Drugs used in ulcer therapy, - prokinetic drugs, - Drugs emetics and antiemetics, - Laxatives and anti-diarrheal drugs (outline) Drugs used in the treatment of diabetes (insulin and oral hypoglycemic agents) Respiratory system - Drugs used in asthma therapy. and allergic rhinitis - Drugs against the cough. and mucolytics (outline) cardiovascular system - Antihypertensive - antianginal drugs - antiarrhythmic drugs (outline) - Drugs used in heart failure - Drugs for blood disorders Musculoskeletal system - Nonsteroidal anti-inflammatory drugs - Glucocorticoids. Central nervous system - Drugs central analgesics - antianxiety drugs - hypnotic. - Antidepressant medications. - Pain therapy - Drugs used in Parkinson's disease - Drugs used in Alzheimer's disease antimicrobial chemotherapy - Main classes of antibacterial drugs and their clinical use - Drugs active against the main protozoa, fungi, viruses General principles of cancer chemotherapy and major classes of drugs.