Basic sciences

A.Y. 2017/2018
Lesson for
5
Max ECTS
75
Overall hours
SSD
BIO/10 BIO/13 FIS/07
Language
Italian
Learning objectives
- Conoscere i fondamenti della chimica necessari alla comprensione della materia vivente e dei composti organici di interesse per la biochimica;
- Conoscere i meccanismi molecolari e biochimici che stanno alla base dei processi vitali e delle attività metaboliche connesse;
-Conoscere i concetti fondamentali della fisica utili per comprendere ed interpretare i fenomeni fisiologici;
- Conoscere la struttura e le funzioni della cellula eucariota;
- Conoscere i meccanismi di trasmissione e di espressione dell'informazione genetica.

Course structure and Syllabus

Sezione: Busto Arsizio
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Gioia Francesco
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professors: Serio Giovanni, Viale Giovanna
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Imperiale Paolo
Biochimica
Syllabus
Module program:
- Atom, molecules and ions. Chemical bonding: ionic and covalent bonding. Lewis symbols and structures. Electron configuration. The periodic table.
- Intermolecular bonds: hydrogen and van der Waals bonds.
- Solutions: solubility, property of solutions (osmotic pressure), properties of water, concentration.
- Chemical reactions:
-General concepts;
-Balancing chemical equations;
- Redox;
- Kinetics (factors affecting reactions rates, catalysis);
- fundamental equilibrium concepts (chemical equilibria, equilibrium constants, shifting equilibria, Le Chatelier's principle).
Acid-base equilibria:
-Arrhenius and Bronsted -Lowry acids and bases;
- PH and pOH;
- Relative strengths of acids and bases;
- Buffer.
- Introduction to organic molecules and functional groups.
Biomolecules, the molecules of life: carbohydrates, lipids, proteins and amino acids, nucleic acids.
Enzymes: catalytic power, specificity, and regulation.
-Introduction to enzyme kinetics;
-Kinetics of enzyme-catalyzed reactions;
-Enzyme inhibition;
-Controls over enzymatic activity: general considerations;
-The allosteric regulation of enzymatic activity.
ATP and Energy-rich compounds.
Metabolism and Its Regulation
Metabolism - An Overview
-Metabolism consists of catabolism and anabolism;
-Intermediary metabolism is a tightly regulated, integrated process.
Overview of glycolysis, the tricarboxylic acid cycle, electron transport and oxidative phosphorylation.
Overview of carbohydrates metabolism: digestion; origin and metabolic glucose fates; mechanisms of regulation of glucose metabolism.
Overview of lipid metabolism: digestion; origin and metabolic fatty acids fates; mechanisms of regulation of lipid metabolism, ketone bodies.
Overview of amino acid metabolism: digestion; origin and metabolic fates of amino acids; mechanisms of regulation of the metabolism of amino acids.
Biologia applicata
Syllabus
Module program:
- Characteristics of living organisms: cell theory; methods for the cell study; prokaryotic cells; eukaryotic cells; hierarchical organization in biology; evolution of organisms.
- Biological macromolecules: lipids, sugars, nucleic acids, proteins.
- Structure and organization of the eukaryotic cell: cell compartmentalization; cellular organelles; ribosomes; cytoskeleton; junctions; matrix.
- Structure and function of biological membranes: fluid mosaic model; transport through the membrane.
- Cellular communication: modes of communication between cells.
- Cell cycle and its regulation: phases of the cycle; control system; apoptosis; the cancer cell.
- The reproduction of living beings: asexual and sexual reproduction; mitosis, meiosis and their comparison; gametogenesis; fertilization; differentiation.
- DNA replication: central dogma of biology; Meselson and Stahl; replication at the molecular level; repair of DNA damage.
- Transcript: various types of RNA; RNA synthesis; maturation of RNA messengers.
- Translation and genetic code: the genetic code and its properties; protein synthesis mechanism; post-synthetic fate of proteins.
- The genome of eukaryotes: structure of chromatin, the nucleosome; structure of the gene (introns-exons); control of gene expression.
Virus: structure; bacterial viruses, animals and plants; virus-cell interactions.
Human chromosomes and their mode of segregation during mitosis and meiosis
- Organization of DNA in chromosomes and chromatin
- The equational division of somatic cells
- The reduction division of the germ cells
- Gametogenesis and fertilization
The Mendelian laws that regulate the transmission of genes: correlation between genotype and phenotype
- From gene to protein and phenotype: genotype and phenotype relationship
- allelic Interactions: dominant alleles, recessive alleles and codominance
- Law of segregation and independent assortment of characters principle
The mode of transmission of monogenic traits in humans
- Examples of hereditary pathologies monogenic Mendelian transmission (cystic fibrosis, thalassemia, deafness)
- Dominant and autosomal recessive inheritance
- Penetrance and expressivity, multiple alleles (ABO blood groups, Rh).
- Inheritance linked to sex
- Mitochondrial Inheritance
- Genetic heterogeneity
- Family Trees.
Fisica applicata
Syllabus
Module program:
- Introduction - Definition of measure. Fundamental and derived physical quantities. The International System of Units. Basic concepts on vectors (addition, subtraction, decomposition).
- Kinematics - Trajectory, displacement, velocity, acceleration, uniform rectilinear motion, uniformly accelerated motion.
- Dynamics - Principles of dynamics, gravitational force, force field, the work of a force, mechanical energy, power.
- Statics - Equilibrium conditions of a material point, rigid body, a couple of forces, moment of a force, moment of a couple of forces, a condition of equilibrium of a rigid body, center of gravity, stability of equilibrium, the levers with examples in the human body.
- Fluid statics and dynamics - Aggregation states of matter, density, pressure, and its unit of measurement, the principle of isotropy, Pascal's, Stevino's and Archimedes' laws, flotation, hydraulic jacks, pressure gauges, flow rate and the law of Hagen-Poiseuille
- Calorimetry - Temperature, dilatometric thermometer, ideal gas law, heat, mechanical equivalent of heat, specific heat, conduction, convection, radiation.
- Electrostatics and electric currents - Electric charge, Coulomb's law, potential and potential energy, potential difference, conductors and insulators, capacitance of a capacitor, electric current, Ohm's law, resistors in series and in parallel, thermal effect.
- Radiation - Ionizing radiation, natural and artificial sources, radioactivity, decay, X-ray.
Sezione: Cernusco
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Vitali Franco
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: Fontana Paolo
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Sezione: Crema
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Carioni Vienna Anna
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: La Piana Giuseppe
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Nosue' Samanta
Sezione: Don Gnocchi
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: Viale Giovanna
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Gramatica Furio
Sezione: Fatabenefratelli
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: Viale Giovanna
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Cravero Silvio
Sezione: IEO
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Zorzino Laura
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: Rescigno Maria
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Cirillo Ugo
Sezione: Istituto Tumori
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: Mastroianni Antonio
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Carrara Mauro
Sezione: Magenta
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Covini Nevie
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: Galli Laura Morena
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Benedetti Gianluca
Sezione: Niguarda
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Masarin Adriano
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: Francolini Maura
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Badi Carlo Maria
Sezione: Policlinico
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: Villa Stefania
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Ranieri Paolo
Sezione: Rho
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Tinti Stefania
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professors: Olivieri Giulia, Zampiero Alberto
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: De Maria Beatrice
Sezione: Sacco
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professors: Infusino Concetta Ylenia, Ottria Roberta
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: Tonello Cristina
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Porta Alberto
Biochimica
Syllabus
Module program:
Atom, molecules and ions. Chemical bonding: ionic and covalent bonding. Lewis symbols and structures. Electron configuration. The periodic table.
Intermolecular bonds: hydrogen and van der Waals bonds.
Solutions: solubility, property of solutions (osmotic pressure), properties of water, concentration.
Chemical reactions:
-general concepts;
-balancing chemical equations;
-redox;
-kinetics (factors affecting reactions rates, catalysis);
-fundamental equilibrium concepts (chemical equilibria, equilibrium constants, shifting equilibria, Le Chatelier's principle).
Acid-base equilibria:
-Arrhenius and Bronsted -Lowry acids and bases;
-pH and pOH;
-relative strengths of acids and bases;
-buffer.
Introduction to organic molecules and functional groups.
Biomolecules, the molecules of life: carbohydrates, lipids, proteins and amino acids, nucleic acids.
Enzymes: catalytic power, specificity, and regulation.
-Introduction to enzyme kinetics;
-kinetics of enzyme-catalyzed reactions;
-enzyme inhibition;
-controls over enzymatic activity: general considerations;
-the allosteric regulation of enzymatic activity.
ATP and Energy-rich compounds.
Metabolism and Its Regulation
Metabolism - An Overview
-metabolism consists of catabolism and anabolism;
-intermediary metabolism is a tightly regulated, integrated process.
Overview of glycolysis, the tricarboxylic acid cycle, electron transport and oxidative phosphorylation.
Overview of carbohydrates metabolism: digestion; origin and metabolic glucose fates; mechanisms of regulation of glucose metabolism.
Overview of lipid metabolism: digestion; origin and metabolic fatty acids fates; mechanisms of regulation of lipid metabolism, ketone bodies.
Overview of amino acid metabolism: digestion; origin and metabolic fates of amino acids; mechanisms of regulation of the metabolism of amino acids.
Biologia applicata
Syllabus
Module program:
Characteristics of living organisms: cell theory; methods for the cell study; prokaryotic cells; eukaryotic cells; hierarchical organization in biology; evolution of organisms.
Biological macromolecules: lipids, sugars, nucleic acids, proteins.
Structure and organization of the eukaryotic cell: cell compartmentalization; cellular organelles; ribosomes; cytoskeleton; junctions; matrix.
Structure and function of biological membranes: fluid mosaic model; transport through the membrane.
Cellular communication: modes of communication between cells.
Cell cycle and its regulation: phases of the cycle; control system; apoptosis; the cancer cell.
The reproduction of living beings: asexual and sexual reproduction; mitosis, meiosis and their comparison; gametogenesis; fertilization; differentiation.
DNA replication: central dogma of biology; Meselson and Stahl; replication at the molecular level; repair of DNA damage.
Transcript: various types of RNA; RNA synthesis; maturation of RNA messengers.
Translation and genetic code: the genetic code and its properties; protein synthesis mechanism; post-synthetic fate of proteins.
The genome of eukaryotes: structure of chromatin, the nucleosome; structure of the gene (introns-exons); control of gene expression.
Virus: structure; bacterial viruses, animals and plants; virus-cell interactions.
Human chromosomes and their mode of segregation during mitosis and meiosis
- Organization of DNA in chromosomes and chromatin
- The equational division of somatic cells
- The reduction division of the germ cells
- Gametogenesis and fertilization
The Mendelian laws that regulate the transmission of genes: correlation between genotype and phenotype
- From gene to protein and phenotype: genotype and phenotype relationship
- Allelic Interactions: dominant alleles, recessive alleles and codominance
- Law of segregation and independent assortment of characters principle
The mode of transmission of monogenic traits in humans
- Examples of hereditary pathologies monogenic Mendelian transmission (cystic fibrosis, thalassemia, deafness)
- Dominant and autosomal recessive inheritance
- Penetrance and expressivity, multiple alleles (ABO blood groups, Rh).
- Inheritance linked to sex
- Mitochondrial Inheritance
- Genetic heterogeneity
- Family Trees.
Fisica applicata
Syllabus
Module program:
- Introduction - Definition of measure. Fundamental and derived physical quantities. The International System of Units. Basic concepts on vectors (addition, subtraction, decomposition).
- Kinematics - Trajectory, displacement, velocity, acceleration, uniform rectilinear motion, uniformly accelerated motion.
- Dynamics - Principles of dynamics, gravitational force, force field, the work of a force, mechanical energy, power.
- Statics - Equilibrium conditions of a material point, rigid body, a couple of forces, moment of a force, moment of a couple of forces, a condition of equilibrium of a rigid body, center of gravity, stability of equilibrium, the levers with examples in the human body.
- Fluid statics and dynamics - Aggregation states of matter, density, pressure, and its unit of measurement, the principle of isotropy, Pascal's, Stevino's and Archimedes' laws, flotation, hydraulic jacks, pressure gauges, flow rate and the law of Hagen-Poiseuille
- Calorimetry - Temperature, dilatometric thermometer, ideal gas law, heat, mechanical equivalent of heat, specific heat, conduction, convection, radiation.
- Electrostatics and electric currents - Electric charge, Coulomb's law, potential and potential energy, potential difference, conductors and insulators, capacitance of a capacitor, electric current, Ohm's law, resistors in series and in parallel, thermal effect.
- Radiation - Ionizing radiation, natural and artificial sources, radioactivity, decay, X-ray.
Sezione: San Carlo
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Paroni Rita Clara
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: Perin Silvana
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Totaro Domenico
Sezione: San Donato
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Anastasia Luigi
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professors: Rigolini Roberta, Viale Giovanna
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Ardu Veronica
Biologia applicata
Syllabus
Module program:
- Characteristics of living organisms: cell theory; methods for the cell study; prokaryotic cells; eukaryotic cells; hierarchical organization in biology; evolution of organisms.
- Biological macromolecules: lipids, sugars, nucleic acids, proteins.
- Structure and organization of the eukaryotic cell: cell compartmentalization; cellular organelles; ribosomes; cytoskeleton; junctions; matrix.
- Structure and function of biological membranes: fluid mosaic model; transport through the membrane.
- Cellular communication: modes of communication between cells.
- Cell cycle and its regulation: phases of the cycle; control system; apoptosis; the cancer cell.
- The reproduction of living beings: asexual and sexual reproduction; mitosis, meiosis and their comparison; gametogenesis; fertilization; differentiation.
- DNA replication: central dogma of biology; Meselson and Stahl; replication at the molecular level; repair of DNA damage.
- Transcript: various types of RNA; RNA synthesis; maturation of RNA messengers.
- Translation and genetic code: the genetic code and its properties; protein synthesis mechanism; post-synthetic fate of proteins.
- The genome of eukaryotes: structure of chromatin, the nucleosome; structure of the gene (introns-exons); control of gene expression.
- Virus: structure; bacterial viruses, animals and plants; virus-cell interactions.
Human chromosomes and their mode of segregation during mitosis and meiosis
- Organization of DNA in chromosomes and chromatin
- The equational division of somatic cells
- The reduction division of the germ cells
- Gametogenesis and fertilization
The Mendelian laws that regulate the transmission of genes: correlation between genotype and phenotype
- From gene to protein and phenotype: genotype and phenotype relationship
- Allelic Interactions: dominant alleles, recessive alleles and codominance
- Law of segregation and independent assortment of characters principle
The mode of transmission of monogenic traits in humans
- Examples of hereditary pathologies monogenic Mendelian transmission (cystic fibrosis, thalassemia, deafness)
- Dominant and autosomal recessive inheritance
- Penetrance and expressivity, multiple alleles (ABO blood groups, Rh).
- Inheritance linked to sex
- Mitochondrial Inheritance
- Genetic heterogeneity
- Family Trees.
Sezione: San Giuseppe
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: Viale Giovanna
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Bari Vlasta
Sezione: San Paolo
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Signorelli Paola
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
E-learning: 10 hours
Professor: Gallina Andrea
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Castelli Mario Ambrogio
Lesson period
First semester
Assessment methods
Esame
Assessment result
voto verbalizzato in trentesimi