Fundamental definitions and concepts in Analytical Chemistry; Elements of statistics applied to analytical chemistry; interpretation of acid/base, precipitation, complexation and redox equilibria, with application to volumetric analysis; electroanalysis: conductimetry, potentiometry, voltammetry, amperometry.
Criteria for evaluating the reliability of analytical data; ability to interpret acido/base, precipitation, complexation and redox equilibria, particularly concerning titration curves; basic knowledge of the fundamental electroanalytic techniques (conductimetry, potentiometry, voltammetry, amperometry)
Course content [required]
Part 1 Propedaeutic concepts Analytical Chemistry: definition, history, significance. Analytical methods. Sequence of steps in a typical quantitative analysis. Sampling. Elements of theory of errors applied to analytical chemistry; criteria for data treatment and statistical tests. Concentration scales, ionic strength, activities, activity coefficients. Equilibrium constants, standard states. Nernst law, galvanic cells, ion-reversible electrodes, electrode potential scale.
Part 2 Volumetric analysis. Titration methods: definitions, classification, standards. Acid/base, precipitation, complessation and redox titrations: mathematical descriptions of the corresponding equilibria and titration diagrams; in particular, De Levie method for easy unapproximated simulation of acid/base equilibria and titration curves even in very complex cases.
Part 3 Electroanalysis. Conductimetry, potentiometry (ion-selective electrodes, pH-metry, p-Ionometry, redox potential, water hardness), voltammetry (cyclic voltammetry, polarography, pulsed techniques, stripping techniques for trace analysis), amperometry (trace water by Karl Fischer method, dissolved oxygen by Clark method), biosensors and electronic tongues/noses (hints). Fundamentals, instrumentation, protocols (standardization, direct measurements, instrumental titrations). Model cases in the analytical laboratory and in fundamental and applied research.
General and Inorganic Chemistry and General and Inorganic Chemistry Laboratory.
Lecture notes and model spreadsheets provided on the instructor's website.
Recommended textbook: Douglas A. Skoog, Donald M. West, F. James Holler, Fundamentals of Analytical Chemistry, Brooks Cole.
(or, as an alternative: Daniel C. Harris, Quantitative Chemical Analysis, W.H.Freeman & Co.)
Fundamentals of general and inorganic chemistry, basic stoichiometry, elements of mathematical analysis and of numerical methods.
Written examination (3 hours) on the whole program, divided into 3 sections, corresponding to the 3 parts of the course. The sections concerning propaedeutic concepts and volumetric analysis include several questions requiring short answers, plus a lot of short numerical exercises/little problems (requiring a pocket scientific calculator). The electroanalysis section includes three subsections with many questions requiring short answers (on i) conductimetry; ii) potentiometry; iii) voltammetry & complements).
Language of instruction
Attendance is strongly recommended
Mode of teaching