Pharmacology and Toxicology

A.Y. 2017/2018
Lesson for
10
Max ECTS
80
Overall hours
SSD
BIO/14
Language
Italian
Learning objectives
Questo insegnamento consente di acquisire un linguaggio e nozioni di base attraverso cui xenobiotici e molecole di sintesi o di origine naturale interagiscono esercitano attività farmacologica e caratteristiche tossicologiche su cellule, organi, tessuti o organismi viventi.

Course structure and Syllabus

Active edition
Yes
Responsible
Pharmacology
BIO/14 - PHARMACOLOGY - University credits: 6
Lessons: 48 hours
Professor: Camera Marina
Toxicology
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 32 hours
Professor: Lecca Davide
ATTENDING STUDENTS
Pharmacology
Syllabus
General Pharmacology
· The areas of pharmacology. Development of new compounds.
· Insights in Clinical Pharmacology.
· Pharmacokinetics and Pharmacodynamics : The dynamic of drug absorption, distribution, action, and elimination.
· Drug biotransformation (metabolism).
· Receptors: classification-structural and functional families.
· Quantitation of drug-receptor interactions and effects.
· Signal transduction and second messengers.
· Chemical mediators
· Inflammation and antiinflammatory drugs. 1
· Inflammation and antiinflammatory drugs. 2

Neurotransmission: the autonomic and somatic motor nervous system
- Drugs acting at synaptic and neuroeffector junctional sites
Neurotransmission and the central nervous system
- Anesthetics, Hypnotics and Sedatives
- Drug therapy of depression and anxiety disorders
- Treatment of Central Nervous System Degenerative disorders
- Opioid Analgesic
- Drug Addiction and Drug Abuse
The cardiovascular and renal systems

- Treatment of myocardial ischemia
- Diuretics
- Therapy of Hypertension
- Renin/Angiotensin system and drugs
- Lipid metabolism and atherosclerosis: General principles.
- Cardiovascular risk factors and prevention. Drugs affecting lipid metabolism.
- Antithrombotic drugs.
- Pharmacotherapy of congestive heart failure.
Gastrointestinal tract
- Gastrointestinal physiology.
- Drugs affecting the gastric secretion.
- Treatment of gastrointestinal motility.
The respiratory system
Physiology and pharmacotherapy of asthma.
Lifestyle, sport and drugs
Pharmacological effects of food components
- the example of polyunsaturated fatty acids for the treatment of cardiovascular and neurodegenerative disorders.

The examination consists in an oral exam with aimed at verifying the following aspects:
- Knowledge and understanding;
- Making judgements;
- Communication skills;
- Learning skills.
Toxicology
Syllabus
- Principles of toxicology
- Mechanisms of toxicity and reparative mechanisms
- Toxicity of drugs and herbal remedies
- Food toxicology
- Toxicity tests
- Genotoxicity and carcinogenicity
- Immunotoxicity
- Skin toxicity
- Eye toxicity
- Liver toxicity
- Kidney toxicity
- Neurotoxicity
- Developmental toxicity
- Lung toxicity
- Risk assessment
- Environmental contamination and toxicology
- Metal toxicity
- Solvent toxicity
- Pesticide poisoning
- Natural toxins
NON-ATTENDING STUDENTS
Pharmacology
Syllabus
General Pharmacology
· The areas of pharmacology. Development of new compounds.
· Insights in Clinical Pharmacology.
· Pharmacokinetics and Pharmacodynamics : The dynamic of drug absorption, distribution, action, and elimination.
· Drug biotransformation (metabolism).
· Receptors: classification-structural and functional families.
· Quantitation of drug-receptor interactions and effects.
· Signal transduction and second messengers.
· Chemical mediators
· Inflammation and antiinflammatory drugs. 1
· Inflammation and antiinflammatory drugs. 2

Neurotransmission: the autonomic and somatic motor nervous system
- Drugs acting at synaptic and neuroeffector junctional sites
Neurotransmission and the central nervous system
- Anesthetics, Hypnotics and Sedatives
- Drug therapy of depression and anxiety disorders
- Treatment of Central Nervous System Degenerative disorders
- Opioid Analgesic
- Drug Addiction and Drug Abuse
The cardiovascular and renal systems

- Treatment of myocardial ischemia
- Diuretics
- Therapy of Hypertension
- Renin/Angiotensin system and drugs
- Lipid metabolism and atherosclerosis: General principles.
- Cardiovascular risk factors and prevention. Drugs affecting lipid metabolism.
- Antithrombotic drugs.
- Pharmacotherapy of congestive heart failure.
Gastrointestinal tract
- Gastrointestinal physiology.
- Drugs affecting the gastric secretion.
- Treatment of gastrointestinal motility.
The respiratory system
Physiology and pharmacotherapy of asthma.
Lifestyle, sport and drugs
Pharmacological effects of food components
- the example of polyunsaturated fatty acids for the treatment of cardiovascular and neurodegenerative disorders.

The examination consists in an oral exam with aimed at verifying the following aspects:
- Knowledge and understanding;
- Making judgements;
- Communication skills;
- Learning skills.
Toxicology
Syllabus
- Principles of toxicology
- Mechanisms of toxicity and reparative mechanisms
- Toxicity of drugs and herbal remedies
- Food toxicology
- Toxicity tests
- Genotoxicity and carcinogenicity
- Immunotoxicity
- Skin toxicity
- Eye toxicity
- Liver toxicity
- Kidney toxicity
- Neurotoxicity
- Developmental toxicity
- Lung toxicity
- Risk assessment
- Environmental contamination and toxicology
- Metal toxicity
- Solvent toxicity
- Pesticide poisoning
- Natural toxins
Lesson period
Second semester
Lesson period
Second semester
Assessment methods
Esame
Assessment result
voto verbalizzato in trentesimi