The course aims to develop knowledge on the pathogenic basis of human diseases, with particular attention to limits and benefits of the main experimental models available and their correlation with clinical presentation of the disease. It is based on a series of lectures grouped on thematic sections and focusing on pathogenic mechanisms and experimental approaches. The course also includes two journal club sessions held by the students on selected scientific articles proposed by the Faculty, aimed at developing the student's ability to critical reading, presentation, and discussion of the scientific data.
Students will acquire an integrated comprehension of the pathogenic basis of human pathology and on the correlation of pathogenic mechanisms and clinical manifestations. They will also acquire information on potentials and limitations of experimental models available. The journal club sessions will allow them to develop critical reading, presentation, and scientific data discussion abilities
Immunomediated diseases Pathogenic mechanisms in allergic diseases Pathogenic mechanisms in primary and acquired immunodeficiencies The inflammasome and autoinflammatory syndromes Inflammation resolution: molecular mechanisms and experimental models Transplantation immunology The graft versus host disease: experimental models and implications for bone marrow transplant Role of the immune response in liver transplant rejection Role of microbiota on immune response and autoimmune diseases
Oncology Immunity and cancer: Role of adaptive immunity in cancer Inflammation and cancer: intrinsic and extrisic inflammation in cancer promotion Inflammation and cancer in experimental models Ovary carcinoma: clinical presentation and experimental models Molecular phenotypes of mammary carcinoma: clinical presentations and experimental models In vivo imaging techniques (CT, MRI, PET, SPECT, ultrasound) Optical in vivo imaging Metastasis experimental models and their visualization in vivo
Infectious diseases Pathogen recognition and septic shock Immunothrombosis: hemostasis and innate immunity interplay Soluble pathogen recognition receptors in infectious models Immune escape mechanisms in experimental infectious models
Iron metabolism and erythropoiesis: The anemias; Iron overload disorders; Iron metabolism and hereditary hemochromatosis
Metabolic diseases: The metabolic syndrome and type 2 diabetes; Experimental models of insulin resistance and nonalcoholic fatty liver disease; Pathophysiology and genetics of a complex disease: nonalcoholic steatohepatitis.
Liver and kidney disease Liver diseases and hepatocellular carcinoma Human genetics and models of metabolic diseases Kidney diseases Experimental models for study the life cycle and therapeutic approaches to hepatitis C virus infection
Diseases of cardiovascular system: the crosstalk between haemostasis, immune and inflammatory response, and damage repair: Thrombosis, thrombogenesis and thrombotic diseases; Aterosclerosis and arterial thrombosis: coronary heart disease and ischemic cerebrovascular disease; Venous thromboembolism; Heart remodeling in systemic hypertension, heart failure, coronary heart disease, and atrial fibrillation; Seminar: Modeling biologic systems: network based simulation for translational medicine: an application to anticoagulation; Antithrombotic pharmacological and non-pharmacological therapy.
Aging and age-related diseases between genetics, epigenetics and enviromental noxae: Aging; Seminar: Cerebral aging and neurodegenerative diseases. Alzheimer disease and biomarkers; Inflammaging, immune senescence and premature lung aging in the pathogenesis of respiratory diseases: COPD and interstitial lung diseases.