Experimental immunology and immunobiotechnology

A.Y. 2018/2019
Lesson for
6
Max ECTS
42
Overall hours
SSD
MED/04 MED/16 MED/46 VET/05
Language
English
Learning objectives
The course aims at providing a general understanding of potentials and limitations of experimental immunology approaches to the understanding on molecular and cellular mechanisms underlying human immunopathology, here developed approaching a selection of immunological diseases as cases of study.
The students will learn how to investigate on the pathogenesis of models of human diseases starting from the unanswered clinical and biological questions. The knowledge of the advanced biotechnologies and of animal models will make it possible to understand what technical tools and approaches are currently available to disclose the cellular and molecular mechanisms of human diseases.

Course structure and Syllabus

Active edition
Yes
Responsible
Domestic animal infectious diseases
VET/05 - INFECTIOUS DISEASES OF DOMESTIC ANIMALS - University credits: 2
Lessons: 14 hours
Professor: Riva Federica
General pathology and immunology
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 1
Lessons: 7 hours
Professor: Locati Massimo
Laboratory medicine
MED/46 - BIOTECHNOLOGY AND METHODS IN LABORATORY MEDICINE - University credits: 2
Lessons: 14 hours
Professor: Mavilio Domenico
Reumatology
MED/16 - RHEUMATOLOGY - University credits: 1
Lessons: 7 hours
General pathology and immunology
Syllabus
Potential and Limitations of modern biotechnologies to be used to investigate on the pathogenesis of the above-mentioned autoimmune diseases (Flow Cytometry - Omics - Gene Therapies - Approaches of Translational Medicine).
Reumatology
Syllabus
Lessons introducing the current knowledge in regard to the physiopathology of the following auto-immune diseases:
a) Systemic Lupus Erythematosus (SLE);
b) Antiphospholipid Syndrome (APS);
c) Systemic Sclerosis (SSc);
d) Vasculitis. (Cellular and molecular mechanisms - Biomarkers and autoantibodies - Novel therapeutic approaches - Transplant in autoimmunity - Biological Therapies).
Laboratory medicine
Syllabus
Each student will be asked to focus on a specific aspect related to experimental immunology and immunobiotechnology implications for each defined theme working on a selection of research articles indicated by the Faculty. This step will be developed in a series of meetings with the tutor.
Domestic animal infectious diseases
Syllabus
Potential and Limitations of the murine models associated to the above-mentioned autoimmune disorders (Production and analysis of transgenic animals - Gene targeting technologies - Production and analysis of knock out animals - Conditional gene targeting - In vivo experiment planning - Legislation - Models of experimental pathology in autoimmunity and transplantation - Production and analysis of bone marrow chimeras - Xenografts and humanized mice).
Lesson period
Third trimester
Lesson period
Third trimester
Assessment methods
Esame
Assessment result
voto verbalizzato in trentesimi
Professor(s)
Reception:
On Appointment
Istituto Clinico Humanitas, Via A. ;anzoni 113, Rozzano, Milano