Pathogenesis and diagnostics

A.Y. 2018/2019
Lesson for
6
Max ECTS
90
Overall hours
SSD
BIO/12 MED/04 MED/07 MED/36
Language
Italian
Learning objectives
- Conoscere la struttura dei principali microrganismi patogeni per l'uomo
- Conoscere i meccanismi fisiologici di difesa dell'organismo
- Conoscere il rapporto tra microrganismi patogeni ed ospite nelle infezioni umane
- Conoscere le metodiche e dell'uso delle radiazioni
- Conoscere le metodiche della diagnostica di laboratorio
- Conoscere gli esami di laboratorio e le indagini di diagnostica per immagini tipici dei quadri patologici
- Conoscere i parametri di riferimento della diagnostica di laboratorio e della diagnostica per immagini
- Conoscere le norme di radioprotezione vigenti
- Conoscere le cause, i meccanismi patogenetici e fisiopatologici delle malattie
- Descrivere le principali alterazioni cellulari nel corso di malattie
- Conoscere il processi flogistico e di cicatrizzazione

Course structure and Syllabus

Sezione: Busto Arsizio
Active edition
Yes
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Gioia Francesco
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Della Bosca Elisa
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Pierdomenico Sandro
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Capra Riccardo
Sezione: Cernusco sul Naviglio
Active edition
Yes
Responsible
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Capitanio Daniele
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Secchi Francesco
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Bianchi Emanuela
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Mascherpa Mauro
Sezione: Crema
Active edition
Yes
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Valdameri Paolo
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Bonetti Cristina
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Inzoli Alessandro
Sezione: Don Gnocchi
Active edition
Yes
Responsible
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Braga Federica
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Xhepa Genti
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professors: Fenizia Claudio, Gnocchi Pierluigi Carlo
Sezione: Fatebenefratelli
Active edition
Yes
Responsible
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Goi Giancarlo
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Ceriani Giosue'
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Grande Romualdo
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Recalcati Stefania
Sezione: IEO
Active edition
Yes
Responsible
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Zorzino Laura
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Bellomi Massimo
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Morace Giulia
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Alcalay Myriam
Sezione: Istituto Tumori
Active edition
Yes
Responsible
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Cascella Tommaso
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Sisto Francesca
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Recalcati Stefania
Sezione: Magenta
Active edition
Yes
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Finazzi Sergio
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Gammella Elena
Sezione: Niguarda
Active edition
Yes
Responsible
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Pastori Stefano
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Bortolato Barbara
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Sezione: Policlinico
Active edition
Yes
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Paroni Rita Clara
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Triulzi Fabio Maria
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Arghittu Milena
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Fenizia Claudio
Biochimica clinica e biologia molecolare clinica
Syllabus
Program of the form:
· Clinical Biochemistry: introduction, purposes, definitions
· Laboratory intervention levels. Types of exams
· Blood sample, urine sample
· Other types of biological samples
· Total variability concept; Biological variability and factors that influence it
· Preparation of the subject / patient
· Pre-analytical variability: sampling, conservation, delivery transport
· Acceptability criteria of a biological sample
· Analytical variability
· Types of errors. Reliability of a dosing method
· Quality controls
· Post-analytical variability: diagnostic report
· Reference values
· Analytical goals and critical difference
· Diagnostic logic: sensitivity and clinical specificity, predictive values
· Deepening of some topics chosen by the teacher (The role of the Laboratory in the hearth infarct, in diabetes, in liver diseases, in dyslipidemia ..)
Microbiologia e microbiologia clinica
Syllabus
Program of the form:
Major differences in the cells of prokaryotes and eukaryotes including the structure, organization and reproduction - Differences among bacteria, fungi and viruses.
· Vertical and horizontal transmission of microorganisms and impact of vehicles and carriers - Principal characteristics of pathogenicity and virulence of microorganisms
· Main interactions host - infectious agent: colonization, symbiosis, commensalism, infection and disease - Host factors that can influence the infectious process
· Criteria for the collection and transport of biological samples for microbiological diagnosis in the laboratory. Direct and indirect diagnosis of infection
· Main direct and indirect microbiological investigations - Investigations in relation to the stage of infection (recently, pregressed or chronic) and therapy (drug susceptibility tests for antimicrobial drugs)
· Morphology, ultrastructure and functions of the different components of the bacterial cell, chemical composition and cell wall structure of Gram-positive and Gram negative bacteria. Bacterial replication.
· Mechanism of action of antibacterial drugs: cell wall synthesis, cytoplasmic membrane function, protein and nucleic acids synthesis inhibitors. Microbial drug-resistance mechanisms in MDR
· Morphology, ultrastructure and function of the components of the fungal cell, sexual and asexual reproduction -Main drugs with antifungal activity, mechanism of action and possible development of resistance - Morphology, functions, and reproduction mode in Protozoa
· Origin, organization and mode of replication of human viruses. Persistent, slow, latent viral infection. Antiviral drugs and mechanisms of action
· Normal resident microbiota composition
· Staphylococcus aureus, coagulase-negative staphylococci, Streptococcus spp, pathogenic Neisseria, Enterobacteriaceae, spore-forming bacilli, mycobacteria
· Morphological characteristics, culture and pathogenicity of the main fungal agents with particular reference to the genera Candida, Cryptococcus and Aspergillus
· Protozoa of human interest
· Main agents of viral infections (Herpesviridae, Orthomyxoviridae, Paramyxoviridae, Picornaviridae) Retroviridae and hepatitis viruses).
· Nosocomial infections: definition, risk factors and major pathogens
Diagnostica per immagini e radioterapia
Syllabus
Program of the form:
· Physics: ionizing radiations and the electromagnetic spectrum , the corpuscolar radiations, the sources of ionizing radiation , principles of dosimetry.
· Radiobiology: the effects of ionizing radiations on the physic matter, general principles. The effects of the ionizing radiation on the biological systems, the dose related effects, and the stochastic effects
· Radioprotection: the general principles of radioprotection and the National reference legislation. The role of the Medical Physicist. The practical aspects of radioprotection in the clinical setting
· Radiodiagnostic: the techniques based on X ray, conventional radiology, computerized tomography and angiography. The interventional techniques. The iodinate contrast media and the potential adverse reactions
· Nuclear Medicine: main techniques in Nucelr Medicine, SPECT, PET, and PET CT
· Radiotherapy: main techniques in Radiotherapy, patient positioning techniques
· Magnetic Resonance Imaging: general principles and the potential risk of high field magnet. Paramagnetic contrast media, indications and potential adverse effects
Sezione: RHO
Active edition
Yes
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Braga Federica
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Mauri Carla
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Giuliani Giuseppe
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Bollina Roberto
Sezione: S. Paolo
Active edition
Yes
Responsible
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Barassi Alessandra
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Borghi Elisa
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Scita Giorgio
Sezione: Sacco
Active edition
Yes
Responsible
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Braga Federica
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Vanzulli Angelo
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Mariotti Massimo
Sezione: San Carlo
Active edition
Yes
Responsible
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Paroni Rita Clara
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Zoffoli Elena
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Sezione: San Donato
Active edition
Yes
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Professor: Gelfi Cecilia
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Gaia Paola
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Pastorelli Luca
Sezione: San Giuseppe
Active edition
Yes
Biochimica clinica e biologia molecolare clinica
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 1
Lessons: 15 hours
Diagnostica per immagini e radioterapia
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 1
Lessons: 15 hours
Professor: Motta Fabio Angelo
Microbiologia e microbiologia clinica
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Deflorio Loredana
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 30 hours
Professor: Baravelli Massimo
Lesson period
Second semester
Assessment methods
Esame
Assessment result
voto verbalizzato in trentesimi