Basic sciences

A.Y. 2018/2019
Lesson for
5
Max ECTS
75
Overall hours
SSD
BIO/10 BIO/13 FIS/07
Language
Italian
Learning objectives
- Conoscere i fondamenti della chimica necessari alla comprensione della materia vivente e dei composti organici di interesse per la biochimica;
- Conoscere i meccanismi molecolari e biochimici che stanno alla base dei processi vitali e delle attività metaboliche connesse;
-Conoscere i concetti fondamentali della fisica utili per comprendere ed interpretare i fenomeni fisiologici;
- Conoscere la struttura e le funzioni della cellula eucariota;
- Conoscere i meccanismi di trasmissione e di espressione dell'informazione genetica.

Course structure and Syllabus

Sezione: Busto Arsizio
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Gioia Francesco
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Professors: Gallina Andrea, La Piana Giuseppe, Re Francesco
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Sezione: Cernusco sul Naviglio
Active edition
Yes
Responsible
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Vitali Franco
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Sezione: Crema
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Sezione: Don Gnocchi
Active edition
Yes
Responsible
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Professor: Francolini Maura
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Giavazzi Fabio
Sezione: Fatebenefratelli
Active edition
Yes
Responsible
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Paroni Rita Clara
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Professor: Viale Giovanna
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Cerbino Roberto
Sezione: IEO
Active edition
Yes
Responsible
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Paroni Rita Clara
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Professor: Viale Giovanna
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Cerbino Roberto
Sezione: Istituto Tumori
Active edition
Yes
Responsible
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Sezione: Magenta
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Paroni Rita Clara
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Professor: Viale Giovanna
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Cerbino Roberto
Sezione: Niguarda
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Professor: Francolini Maura
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Giavazzi Fabio
Sezione: Policlinico
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Zampiero Alberto
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Biologia applicata
Syllabus
Program of the mode:
Characteristics of living organisms: cell theory; methods for studying cells; prokaryotic cells; eukaryotic cells; hierarchical organization in biology; evolution of organisms. Viruses are genetic parasites of bacterial and eukaryotic organisms

Informational macromolecules and the central dogma of biology: DNA, RNA, proteins.

Structure and organization of the eukaryotic cell: cell compartmentalization; membranous organelles and endosymbiotic organelles; ribosomes; cytoskeleton; junctions; extracellular matrix.

Cellular communication: mechanisms of communication between cells.

The eukaryotic cell cycle and its regulation: phases of the cycle; control mechanisms; apoptosis; the cancer cell.

The reproduction of living things: asexual and sexual reproduction; mitosis, meiosis and their comparison; gametogenesis; fertilization; differentiation.

DNA replication: Meselson and Stahl and the semiconservative replication of double helix; replication at the molecular level; repair of DNA damage.

Transcription: various types of RNA; RNA synthesis; maturation of messenger RNAs.

Translation and the genetic code: deciphering the genetic code; the ribosome and the protein synthesis mechanism; post-synthetic fate of proteins.

The genome of eukaryotes: the structure of nucleosomes and chromatin; structure of the gene (introns-exons); control of gene expression.

Mendel's laws
From gene to protein to phenotype: the genotype-phenotype relationship
Allelic interactions: dominant and recessive phenotypes; incomplete dominance and co-dominance
The law of segregation of characters and the law of independent assortment

The mode of transmission of Mendelian traits in humans
Modes of inheritance: autosomal dominant and recessive, X-linked, Y-linked, maternal (mitochondrial)
Examples of inherited monogenic diseases (sickle cell anemia, cystic fibrosis, Huntington's chorea, hemophilia B)
Locus heterogeneity
Penetrance and expressivity, multiple alleles (ABO and Rh blood groups)
Pedigrees

Brief of cytogenetics
The normal human karyotype
Chromosomal aberrations in number and structure
Examples of chromosomal aberration syndromes: Trisomy 21, 13 and 18; Klinefelter's syndrome and Turner's syndrome; Cri-du-chat syndrome.
Sezione: RHO
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Barocci Fiorella
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Sezione: S. Paolo
Active edition
Yes
Responsible
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Signorelli Paola
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Sezione: Sacco
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Ottria Roberta
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Porta Alberto
Sezione: San Carlo
Active edition
Yes
Responsible
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Paroni Rita Clara
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Professor: Viale Giovanna
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Professor: Cerbino Roberto
Sezione: San Donato
Active edition
Yes
Responsible
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Professor: Anastasia Luigi
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Sezione: San Giuseppe
Active edition
Yes
Biochimica
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 30 hours
Biologia applicata
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Online courses: 10 hours
Fisica applicata
FIS/07 - APPLIED PHYSICS - University credits: 1
Lessons: 15 hours
Lesson period
First semester
Assessment methods
Esame
Assessment result
voto verbalizzato in trentesimi