Anatomical bases and molecular networks in the Central Nervous system and its pathologies

A.Y. 2018/2019
Lesson for
8
Max ECTS
60
Overall hours
SSD
VET/01 VET/03
Language
English
Learning objectives
The course aims to provide an understanding of aspects related to the two main integrative systems of the body, the nervous and endocrine systems. Anatomy, function and hormonal regulation of Central and Peripheral Nervous System is covered with developmental anatomy added when applicable.
The course will also provide information about pathogenesis of the most important neurological diseases, and on the animal models that are used for their study and comprehension.

Course structure and Syllabus

Active edition
Yes
Responsible
Unit: Molecular pathology of the CNS
VET/01 - VETERINARY ANATOMY - University credits: 0
VET/03 - VETERINARY PATHOLOGY - University credits: 0
Practicals: 12 hours
Lessons: 12 hours
Professor: Ceciliani Fabrizio
Unit: Morphology and Function of the CNS
VET/01 - VETERINARY ANATOMY - University credits: 0
VET/03 - VETERINARY PATHOLOGY - University credits: 0
Practicals: 12 hours
Lessons: 24 hours
Professor: Brevini Tiziana
ATTENDING STUDENTS
Unit: Morphology and Function of the CNS
Syllabus
Lectures
CNS organization; Neurons, Ganglia and Nerves (2 hours)
Internal capsule and ventricles; Willis circulatory system (1 hour)
CNS: Brain and cortical areas, pons, midbrain, diencephalon, basal ganglia, cerebellum (3 hours)
Neurotransmitters and neuromodulators of the SNC. Spinal cord (1 hour)
Ascending pathways, somatosensory systems. Descending pathways, motor systems (1 ora)
Development of the brain, spinal cord, and nerves. (1 hour)
Neurogenic areas in the brain (1 hour)
Gene regulation of neurogenesis, differentiation of neural progenitors. (1 hour)
The neurogenic niche. Engrafting and homing of neural progenitorsi. Neuro-phenotype-related experiments using knock -out mice (2 hours)
Sympathetic System (1 hour),
Paraympathetic System (1 hour),
Enteric (1 hour);
Neuroendocrine: Hypotalamus, Pituitary and Pineal glands (2 hours);
Action Potentials and nervous transmission. Myelinization and salutatory transmission (2 hours)
Synapsis. Neuro-muscular junctions; Eccitatoty and inhibitory Neurotransmitters, Reuptake (3 hours)

Practical training
Microscopy session on Neurons, Ganglia and Nerves (2 hours)
Microscopy session on Neural tissue sections (2 hours)
Microscopy session on Spinal cord (C3;T2,L4) (2 hours)
Confocal images of Pituitary and Pineal glands (2 hours)
Microscopy session on Sciatic Nerve (2 hours)
Gap junctions and Synapsis (2 hours)
Data acquisition and analysis from confocal images (2 hours)
Data acquisition and analysis from MRI images (2 hours)
Unit: Molecular pathology of the CNS
Syllabus
LECTURES
Lecture 1: ageing
Lecture 2: Brain inflammation
Lecture 3: Muscular Dystrophy
Lecture 4: Prion diseases
Lecture 5: Alzheimer disease
Lecture 6: Parkinson disease
Lecture 7: Multiple Sclerosis

PRACTICES
Histopathology of the main brain and Peripheral nervous tissue
Purification and activation of blood monocytes as model for working with brain mononuclear cells
NON-ATTENDING STUDENTS
Unit: Morphology and Function of the CNS
Syllabus
Lectures
CNS organization; Neurons, Ganglia and Nerves (2 hours)
Internal capsule and ventricles; Willis circulatory system (1 hour)
CNS: Brain and cortical areas, pons, midbrain, diencephalon, basal ganglia, cerebellum (3 hours)
Neurotransmitters and neuromodulators of the SNC. Spinal cord (1 hour)
Ascending pathways, somatosensory systems. Descending pathways, motor systems (1 ora)
Development of the brain, spinal cord, and nerves. (1 hour)
Neurogenic areas in the brain (1 hour)
Gene regulation of neurogenesis, differentiation of neural progenitors. (1 hour)
The neurogenic niche. Engrafting and homing of neural progenitorsi. Neuro-phenotype-related experiments using knock -out mice (2 hours)
Sympathetic System (1 hour),
Paraympathetic System (1 hour),
Enteric (1 hour);
Neuroendocrine: Hypotalamus, Pituitary and Pineal glands (2 hours);
Action Potentials and nervous transmission. Myelinization and salutatory transmission (2 hours)
Synapsis. Neuro-muscular junctions; Eccitatoty and inhibitory Neurotransmitters, Reuptake (3 hours)

Practical training
Microscopy session on Neurons, Ganglia and Nerves (2 hours)
Microscopy session on Neural tissue sections (2 hours)
Microscopy session on Spinal cord (C3;T2,L4) (2 hours)
Confocal images of Pituitary and Pineal glands (2 hours)
Microscopy session on Sciatic Nerve (2 hours)
Gap junctions and Synapsis (2 hours)
Data acquisition and analysis from confocal images (2 hours)
Data acquisition and analysis from MRI images (2 hours)
Unit: Molecular pathology of the CNS
Syllabus
LECTURES
Lecture 1: ageing
Lecture 2: Brain inflammation
Lecture 3: Muscular Dystrophy
Lecture 4: Prion diseases
Lecture 5: Alzheimer disease
Lecture 6: Parkinson disease
Lecture 7: Multiple Sclerosis

CLASSES
Papers describing in details the histopathological and molecular lesion in the Central and Peripheral nervous system will be uploaded onto ARIEL platform and provided to the students
Lesson period
Second semester
Lesson period
Second semester
Assessment methods
Esame
Assessment result
voto verbalizzato in trentesimi
Educational website(s)
Professor(s)
Reception:
Dipartimento di Scienze Veterinarie e Sanità Pubblica - Sezione Patologia Generale e Parassitologia