System medicine

Dottorati
Doctoral programme (PhD)
A.Y. 2019/2020
Course class
Classe per Dottorati di Ricerca
Study area
Medicine and Healthcare
Inter-university
Università degli Studi di Napoli Federico II
Doctoral programme (PhD)
4
Years
Dipartimento di Oncologia ed Emato-Oncologia - Via Festa del Perdono, 7 - Milano
English
PhD Coordinator
The Medicine field is going through a cultural revolution, pressed by the new knowledge emerging from the fundamental biology (molecular biology, and, more recently, genomics). This knowledge has brought to the development of the Personalized Medicine, based on the identification of the mechanisms in the disease, specific to the given disease and to the patient, and the consequent molecular treatments. Although the Personalized Medicine changed the story of some diseases, for some others there exists a rising discrepancy between the scientific discoveries and their turning into a benefit for the patient. This discrepancy is considered a problem by both the scientific community and the society. The aim of the PhD course is the training of a new generation of basic researchers, able to follow the changes occurring in the biomedicine.

The fundamental elements of the training program are:

· the introduction of basic subjects (mathematics, physics, informatics, statistics);
· the teaching of new models of Translational Research, where the basic researchers work along with the clinicians on the same biomedical problems;
· the foundation of a humanistic culture of the new scientific discoveries (foundational, ethical and sociological basis) and the operative tools (cognitive sciences) which allow the new scientists to interact with the society (patients, policy-makers).
Dipartimento di Oncologia ed Emato-Oncologia - Via Festa del Perdono, 7 - Milano
Title Professor(s)
Unraveling the epigenetic role of DNA transposable elements (TEs) in cancer immunoediting of intratumoral lymphocytes
Systematic dissection of the methyl-proteome by Mass Spectrometry to characterise the molecular impact of protein methylation on stress response and global protein-RNA dynamics
T. Bonaldi
Mass Spectrometry-based profiling of epigenetic marks in breast cancer, for patient stratification and novel target identification
T. Bonaldi
Deciphering the code of protein methylation by MS-Proteomics
T. Bonaldi
Nuclear proteomics to investigate multi-layered gene expression regulation
T. Bonaldi
Genetic analysis of the role of YAP/TAZ in cancer stem cells and chemoresistance
S. Campaner
Genetic and epigenetic analysis of tumor progression in vivo
S. Campaner
Cancer stem cells as drivers and therapeutic targets in ovarian carcinoma
U. Cavallaro
Novel ovarian cancer biomarkers and potential targets
U. Cavallaro
Understanding the molecular role of tumor BRCA suppressor genes
The role of DNA repair and DNA damage response proteins in vertebrate stem cells, embryonic development and cancer
How organelle communication regulates EGFR endocytosis and signaling: relevance to physiology and cancer
Endocytosis, signaling and cancer
Genetic analysis of the replication stress response at mammalian telomeres
Y. Doksani
Replication Stress Response
Y. Doksani
Role of the gut microbiota in the shaping of iNKT cells cytotoxic functions during CRC progression
F. Facciotti
Role of the intestinal microbiota in modulating iNKT cell functions during colorectal cancer progression
F. Facciotti
Epigenomics and regulatory alterations in cancer and genetics diseases
F. Ferrari
Chromatin organization and epigenetics in gene expression regulation
F. Ferrari
Microbiome, serum biomarkers and cancer eatiology/prognosis
S. Gandini
Microbiome, Vitamin D and Colorectal cancer
S. Gandini
High precision radiotherapy: technological and biological aspects
Radiomics and radiogenomics:
Fasting mimicking diet: effects on cancer iron metabolism and sensitization to new anti-tumor therapy.
V. Longo
Fasting mimicking diet as adjuvant therapy in hormone dependent breast and prostate cancer.
V. Longo
Mechanisms of aging and their role in cancer
V. Longo
Studies on the connection between dietary components and signaling pathways
V. Longo
Enhancing tumor T cell infiltration to enable cancer immunotherapy.
T. Manzo
Epigenetic control of CD8+ T cells metabolism to improve pancreatic cancer response to immunotherapy
T. Manzo
Metabolic and epigenetic control of innate immunity in cancer
L. Mazzarella
Predictors of response to combined immunological+epigenetic therapy
L. Mazzarella
Tracing the roots of immune suppression in cancer by single cell multiomics and perturbation analyses
Role of chromatin remodelling activities in adult tissue homeostasis
Dissecting the role of different Polycomb Repressive Complexes 1 activities in transcriptional control
Exploring molecular and cellular mechanisms of cancer progression and metastases
Phenotypic and functional adaptation of cancer cells to the tumor microenvironment as a leading cause of metastatic dissemination
Architectural role of general transcription factor TFIIIC in the human genome
Deconvolution of multilayered networks in single-cell-multiomics
Predictive interpretable models of cancer vulnerabilities via network based integration of multi-omic data
Role of SETDB1- ATF7IP complex in p53-induced senescence.
Dissecting the role of NEDD4 HECT E3 ligase in the pathogenesis of Non Small Cell Lung Cancer.
Ubiquitin and signal trasduction
Role of ubiquitin in endocytosis
Multimodel approach on risk factors and management of cardiotoxicity in cancer patients
Clinical Decision Support system for data interpretation and shared decision-making in oncology
Molecular understanding of aneuploid cell clearance
The role of genome instability in conferring resistance to chemotherapy
Mechanistic insights into the consequences of chromosome segregation errors on cell physiology
Tissue- and environment-specific selection in cancer (epi-)genomes
M. Schaefer
Detection of causative cancer drivers beyond point mutations
M. Schaefer
Microenvironmental exposure and tumor evolution
M. Schaefer
Organoid-based single cell deconvolution of the health impact of endocrine disruptors
Post translational modification crosstalk drives mitotic progression
R. Visintin
Chromosome segregation
R. Visintin
Transcriptional regulation of autophagy and lysosomal function
A. Ballabio
Integrative analysis of cellular reprograming with Single Cell Genomics
D. Cacchiarelli
Genomics analysis of cell fate decisions during pluripotent stem cell differentiation
D. Cacchiarelli
Geen therapy of inherited retinal degenerations
A. Auricchio
Gene editing in retinal and liver for therapy of inherited human diseases
A. Auricchio
The role of autophagy in renal cystic disease
B. Franco
Mitochondrial mediated cell death:implication for neurodegenerative and developmental disorders
B. Franco
Dissection of a novel cell death pathway
B. Franco
Functional and molecular characterization of the channelome in human airway epithelial cells
L. Galietta
New therapies for inborn errors of metabolism
N. Brunetti Pierri
Cargo-specific lysosomal response controls collagen homeostasis and skeletal growth
C. Settembre

Courses list

Not specified period
Courses or activities Professor(s) ECTS Total hours Language
Optional
Biochemistry and molecular biology techniques
4 20 English
Cancer Genetics
2 10 English
Genomics & Proteomics
5 25 English
Science communication
2 10 English
Scientific writing
2 10 English
Statistics
5 25 English
Not specified period
Courses or activities Professor(s) ECTS Total hours Language
Optional
Genomics & Proteomics
5 25 English
Science communication
2 10 English
Scientific writing
2 10 English
Statistics
5 25 English
Not specified period
Courses or activities Professor(s) ECTS Total hours Language
Optional
Science communication
2 10 English
Scientific writing
2 10 English
Not specified period
Courses or activities Professor(s) ECTS Total hours Language
Critical thinking
2 10 English
Science communication
2 10 English
Scientific writing
2 10 English

Enrollment

Call for applications: how to do


Please note:
To apply for admission to the phd System Medicine use the following site: http://www.semm.it