Clinical Research

Doctoral programme (PhD)
A.Y. 2019/2020
Course class
Classe per Dottorati di Ricerca
Study area
Medicine and Healthcare
Doctoral programme (PhD)
Dipartimento di Fisiopatologia medico-chirurgica e dei trapianti, Via F. Sforza, 35 - 20122 Milano
PhD Coordinator
Students will learn a correct research approach for studying the causes and the clinical-therapeutic management of diseases.
Specific objectives:
identify clinical issues and uncertainties in pathogenesis, diagnosis, prognosis and in therapeutic approaches in various diseases;
correctly apply different research methodologies (randomized trials, longitudinal, cross-sectional or transversal studies and case control studies);
identify and use biological and genetic markers for studying clinical syndromes, guiding diagnosis and assessing the clinical outcome of different pathologies;
develop critical skills to analyse and comment clinical research results published or presented at national and international conferences;
introduce students to independent clinical research methods and to the issues and critical points relating to ethics in clinical research.
The programme is entirely in English.
Dipartimento di Fisiopatologia medico-chirurgica e dei trapianti, Via F. Sforza, 35 - 20122 Milano
Title Professor(s)
1. Rare autoimmune diseases. 2. Rare skin tumours.
1. Epidemiology, diagnostic pathways and therapy of protozoan diseases (malaria, leishmaniasis, Chagas disease). 2. Antimicrobial stewardship routes.
Epidemiology, pathophysiology, clinics, therapy and complications of the hypotalamic-hypophysis diseases.
Morphological and functional adaptation of right ventricle ad different stages of pulmonary circulation involvement in heart failure patients with reduced ejection fraction.
1. Evaluation of new biomarkers of cardiovascular risk in subjects with non-alcoholic fatty liver disease (NAFLD) or diabetes mellitus identified in the general population. 2. Platelet function and cardiovascular risk.
1. Diseases of the pericardium. 2. Pregnancy in autoimmune diseases.
Neurodevelopmental disorders and epilepsy.
Image-guided percutaneous thermal ablation in the treatment of malignant and benign tumors.
Use of respiratory function tests for the diagnosis and follow-up of complex respiratory diseases.
Endocrine disorders in patients with common diseases (diabetes mellitus and/or obesity and/or hypertension).
Requirements: Knowledge of endocrinology and metabolism, basic-level skills in next-generation sequencing techniques and statistics applied to biomedical research.
1. Clinical methodology (critical evaluation of choosing in medicine and scientific literature). 2. Risk stratification in cardiovascular diseases and in emergency situations, expecially in syncope.
Study of microcirculation:pathophysiologic and clinical implications.
1. Immunopathogenesis of viral infections. 2. Role of the microbiome in MDR bacteria colonization. 3. Antimicrobial stewardship in medicine departments: role in the control of nosocomial infections.
Modulation of the metabolism of the malignancies through the use of metformina and fast mimicking diet.
1. Physiopathological mechanisms of insulin-resistance in obesity and diabetes. 2. Implications for atherosclerosis acceleration and microvascular complications.
Metabolic and cardiovascular complications in non- alcoholic fatty liver disease (NAFLD) from adolescence to adults.
The infection associated cryoglobulinemie: pathogenesis, genetic relates and therapy.
Retinal and choroidal disorders.
Immunotherapy in head and neck tumours.
1. Development of personalized therapies in tumors of the nervous system. 2. New knowledge and surgical therapies in movement disorders.
Use of transcranic electromagnetic stimulation for the treatment of the endocrino-metabolic diseases.
1. Urothelial cancer: new diagnostic and therapeutic approaches. 2. Translational analysis of the impact of HLA-G-related tolerance in overall health in infertile vs. fertile men.
Assesment and modulation of autonomic nervous system in acute and chronic diseases.
Multiparametric, vascular, structural and functional study with RMN in Parkinson's disease.
1. Pathophysiology, clinics and personalized therapeutic strategies in myelodisplastic syndrom and myelodisplastic/myeloproliferative disorders. 2. Allogeneic transplantation of hemopoietic stem-cells and cell therapy in onco-hematology.
1. Pathophysiology, diagnosis and therapy of esophageal diseases. 2. Endoscopic treatment of biliar diseases, especially of the biliar complications after liver transplantation.
HIV infection: clinical, metabolic and pharmacological correlates and focus on genotypic and phenotypic resistance.
Setup of a national database for the functional, respiratoty and clinical characterization in a wide population of patients suffering from cronic obstructive broncho-pulmonary disease.
Impact of hypophysis disease on morbility, wellness, physical and working performance.
Evaluation of the cardiovascular autonomic control in patients suffering from systemic sclerosis.
New pathophysiological knowledge for the design of endovascular treatment of thoracic and abdominal aorta diseases.
1. Safety and efficacy of the Thulium laser system for endoscopic therapy of gastrointestinal lesions: a multicenter study. 2. Novel biomarkers for complicated and non-responsive celiac disease.
1. Epileptic encephalopathies: clinics and traditional and innovative therapeutic approach. 2. Glucose transporter type 1 deficiency syndrome (Glut 1 disease): physiopathology, clinics and therapy.
1. Analysis of the functional outcome in the treatment of inferior alveolar nerve lesions with autologous nerve graft (sural nerve), processed heterologous nerve graft (cryopreserved), and alloplastic graft (collagen tubule). 2. Use of ultrasonic method in the intraoperative evaluation of surgical resection margins of extracranic artero-venous malformations of the cranial-facial region.
Radioprotection in medicine concerning diagnosis treatment and therapy. Risks and benefits evaluation regarding patient characteristics.
1. Development and clinical application of new collagen xenogenous matrices for the regeneration of intra-oral soft tissues. 2. Development and clinical applications of customized Cad/cam titanium meshes for guided bone regeneration of atrophic edentulous jaws.
Autologous dentin matrix and platelet concentrates for alveolar site preservation and bone defects reconstruction procedures in oral surgery.
Morphofunctional analyses of organs and tissues of the oral system.
Development of diagnostic, prognostic and therapeutic programmes using three-dimensional digital and radiographic images in dentistry.
1. Nasal Function. 2. Sleep disorders in ENT.
Modern therapeutic approaches for periodontal and peri-implant diseases.
Biological and imaging markers for differential diagnosis and prognosis of neurodegenerative and demyelinating diseases of the central nervous system.
Custom-made maxillary and mandibular reconstructions prior to implant surgery and maxillofacial oncologic surgery.
Role of the autologous adipose tissue in tissue regeneration, in fibrosis reduction and in scar-pain control.
Etiopathogenesis, diagnosis, treatment and prognosis of mucosal lesions with particular attention towards potentially malignant ones.
Use of titanium grids for the pre-implant bone regeneration.
1. Recurrent infective-inflammatory disease of the upper airways. 2. Mini-invasive surgery for airways obstructions.
Single edentulism treatment through implant-supported rehabilitation with autologous connective or heterologous matrix graft. Multicentric, randomized controlled study.
1. Effects of biophysical stimolation on musculo-skeletal tissues. Experimental study on the osteo-reparative response in the Zebra Fish. 2. Evaluation of transendothelial migration of monocytes in joints of obese patients with osteoarthrosis: prospective randomized clinical study.
Diagnostic, interventional and quantitative radiology of the musculoskeletal system.
Evaluation of molecules with anti-biofilm activity for the prevention and treatment of peri-implantitis.
Efficacy of laser biostimulation in pain and oedema reduction after impacted mandibular third molar extraction: multicentric, randomized study.
1. Study and treatment of the pathologies of cornea and ocular surface. 2. The eye: a window to the soul of the immune system.
Study of the progression of reticular drusen.
The complications in clinical trial: management and medical liability.
1. Regeneration of Periodontal and peri-implant tissues, in particular surgical techniques, scaffolds and growth factors. 2. Development of 3D printed scaffolds for the regeneration of maxillary processes.


Places available: 10

Call for applications: how to do, attachment 1, Qualifications assessment and exam schedule

Application period: from 06-03-2019 to 07-05-2019
Enrolment period: from 09-23-2019 to 09-27-2019
Please note:
The English version of Public Competition for Admission to Doctoral Research Programme in Clinical Research at the University of Milan a.y. 2019/2020 (35th cycle) will be published as soon as possible.