Cancer immunology (ONC)

A.A. 2019/2020
6
Crediti massimi
42
Ore totali
SSD
MED/04 MED/06 MED/15
Lingua
Inglese
Obiettivi formativi
Acquisition of immunosurveillance and immunoevasion concepts, knowledge of the biological basis of the tumor escape mechanisms, understanding of the biological rational understanding of the most used approaches for the modulation of the immune response with anti-cancer purposes.
Risultati apprendimento attesi
Specific knowledge on the relationship between the host's immune system and the tumor and the main anti-tumor approaches based on immunomodulatory strategies.
Programma e organizzazione didattica

Edizione unica

Responsabile
Periodo
Terzo trimestre
Programma
General pathology and immunology:
The immune system in the tumor microenvironment: Inflammation in tumor progression; Functional role of tumor-associated leukocytes and other host cells; Immune infiltrate and tumor angiogenesis; Effects of the tumor on local and systemic immune regulation; Tumor-associated regulatory T cells; Tumor-associated suppressor cells of the myeloid lineage (MDSC, TAM, TAN); Tertiary lymphoid structures in the tumor; Therapeutic approaches targeting the tumor microenvironment.
Medical oncology:
Cancer immunology and immunotherapy in solid tumors: History and principles of immune cancer treatment; Predictors of response to immune therapies; Development of anticancer immune agents;
Evidence of efficacy of immune therapies; Immunotherapies in different models of solid cancers; T-cell therapies; Cancer vaccines; Future trends in cancer immune therapy; Toxicity of cancer immune therapies; Sustainability of anticancer agents.
Blood diseases:
Cancer immunology and immunotherapy in hematological tumors: The role of checkpoint inhibitors in Lymphomas; Adoptive immunotherapy for cancer (CAR T cells); Allogenic hematopoietic stem cell transplantation as adoptive immunotherapy in cancer; The targeting of cancer microenvironment (T-reg, MDSC, NK, Dendritic, macrophages): the paradigma of multiple myeloma; The role of the B-cell receptor signaling in lymphoid malignancies.
Prerequisiti
There is no specific preliminary knowledge
Metodi didattici
Frontal lessons based on teaching material available on the Ariel platform or provided directly in the classroom to students.
Class attendance is free.
Materiale di riferimento
PDF files of the lessons. Review article on different topics.
Modalità di verifica dell’apprendimento e criteri di valutazione
Exam based on a written test consisting of 30 closed-ended questions relating to different modules of the program. The test takes place in 1 hour. The basic knowledge of the discipline is assessed. The evaluation is expressed in thirtieths, the results are communicated through the University registration system.
Moduli o unità didattiche
Blood diseases
MED/15 - MALATTIE DEL SANGUE - CFU: 2
Lezioni: 14 ore

General pathology and immunology
MED/04 - PATOLOGIA GENERALE - CFU: 2
Lezioni: 14 ore

Medical oncology
MED/06 - ONCOLOGIA MEDICA - CFU: 2
Lezioni: 14 ore

Docente/i
Ricevimento:
Appuntamento su richiesta telefonica o via email
Dipartimento di Scienze della Salute, Ospedale San Paolo, via di Rudinì 8, Milano. Blocco C, 7° piano.
Ricevimento:
previo appuntamento da concordare via e-mail
Ricevimento:
previo appuntamento da concordare via e-mail
Laboratori area Pieve c/o Istituto Clinico Humanitas
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previo appuntamento da concordare via e-mail
Ricevimento:
su appuntamento +39 02 6444.2291
Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano