Organ physiopathology and histopathology

A.A. 2016/2017
Insegnamento per
10
Crediti massimi
96
Ore totali
SSD
BIO/09 MED/04 VET/03
Lingua
Inglese

Struttura insegnamento e programma

Edizione attiva
Responsabile
Moduli o unità didattiche
Lab of Comparative Histopathology
VET/03 - PATOLOGIA GENERALE E ANATOMIA PATOLOGICA VETERINARIA - CFU: 3
Laboratory individual activity: 16 ore
Lectures: 16 ore

Organ Physiology and Pathology
BIO/09 - FISIOLOGIA - CFU: 0
MED/04 - PATOLOGIA GENERALE - CFU: 0
: 16 ore
Lectures: 48 ore

Prerequisiti e modalità di esame
Each course module is followed by a specific exam aimed to verify that the objectives of each module have been achieved. Exams will cover all the topics presented in each specific module.
The exam of the module "Organ Physiology" consists in an oral examination. For students participating in itinere to the lab tests, their personal outcome will concur to the final evaluation.
The exam of the module "Organ Physiopathology " consists in a written part (3 open questions and short answers (15-30 lines) for each question. Time allotted: 60 minutes) and a subsequent oral part (including a brief discussion of the student's written answers and 2 questions on different topics).
The exam of the module "Histopathology" consists in a written part: 3 open questions and short answer (5-10 lines) for each question. Time allotted: 30 minutes total. Students passing the written part, undergo the oral part consisting in a discussion, mainly based on the written part of each candidate.
Final mark will be the weighted average of module grades.
Organ Physiology and Pathology
Programma
This module will face the basic mechanisms and processes regulating the function of most important organs in humans, such as liver, kidney, lung, skin, gut and nervous system.

Principal of general and cellular physiology
Membrane transports, toxicant metabolism, excretion
Liver physiology
Hepatic functions secretion, clearance
Kidney physiology
Renal filtration, excretion, secretion, clearance
Respiratory physiology
Lung functions, gas exchange, oxygen transport
Acid/Base control, renal and lung buffer systems
Skin physiology: absorption, metabolism
Nervous system physiology, potential, conduction
Autonomic, somatic, motor nervous system
Digestive system physiology
Gastric/gut, motility, secretion, digestion
Materiale didattico e bibliografia
- Guyton and Hall Textbook of Medical Physiology, Author John E. Hall, Ed. Saunders, ISBN 9781455770052
- Human Physiology, L. Sherwood, ISBN-13: 978-1133104551
- Human Physiology: an integrated approach (7th ed. ), D.U. Silverthorn, ISBN-13: 978-0321981226
Lab of Comparative Histopathology
Programma
1. Introduction (2 hours)
· Introduction to the course
· Veterinary pathology: an introduction
· In vivo studies in laboratory animals: the role of pathology
2. General anatomic pathology (6 hours)
· Malformations
· Lesions due to physical agents
· Lesions due to chemical agents
· Nutritional diseases
· Modification of cellular growth
· Degeneration, distrophy, apoptosis, necrosis
· Pathological mineralization and pigmentation
· Circulatory disturbances
· Inflammation
· Tumors
3. Techniques in histology (4 h)
· Necropsy
· Sampling, fixation and processing for histopathology
· Special stainings in histopathology
· Immunohistochemistry (IHC), immunofluorescence (IF), fluorescent in situ hybridization (FISH), transmission and scanning electron microscopy (TEM and SEM)
· Scoring of lesions
· Digital image analysis (DIA)
4. Animal models (2 h)
· Models of cancer
· Models of angiogenesis
· Models of metastasis
· Models of inflammation
5. Spontaneous pathology of laboratory animals (2 h)
6. Special pathology (8 h)
· Liver
· Kidney
· Lung
· Intestine
· Nervous system
· Skin
· Others: bone marrow, lymphatic, genital
Periodo
Primo semestre
Periodo
Primo semestre
Modalità di valutazione
Esame
Giudizio di valutazione
voto verbalizzato in trentesimi
Docente/i
Ricevimento:
dal Lunedì al Venerdì, previo appuntamento
Via Balzaretti 9, Piano 3A
Ricevimento:
su appuntamento
Dipartimento di Scienze Farmacologioche e Biomolecolari
Ricevimento:
Lunedì 10-12
Anatomia patologica, Facoltà di Medicina Veterinaria, Via Celoria 10, Milano