Research and development of new diagnostic and therapeutic metodologies

A.A. 2018/2019
6
Crediti massimi
42
Ore totali
SSD
BIO/11 MED/08 MED/15 MED/36
Lingua
Inglese
Obiettivi formativi
The aims of this course will be to provide an up-date knowledge of novel, emerging basic and technical aspects in the diagnosis and therapeutic approaches in cancer.
In particular, the course will be focused on mouse models, organoids, relevance of NGS in the context of tumor heterogeneity, the emerging role of non coding RNAs as therapeutic platforms,
the advance of minimal residual disease approaches in the management of patients in the era of new drugs, and the physical bases and possible applications of the most important imaging techniques
Risultati apprendimento attesi
In particular, by following this course it will be possible to learn about:
Animal models as diagnostic and therapeutic tools
Rationale for NGS studies in cancer
The clinical relevance of the non coding RNAs
Molecular monitoring of hematological malignancies
Imaging techniques for clinical and pre-clinical oncological studies
Programma e organizzazione didattica

Edizione unica

Responsabile
Periodo
Terzo trimestre
Prerequisiti e modalità di esame
Classification and molecular mechanisms of major hematological and solid tumors
A basic knowledge of mechanisms of oncogenesis
Basic principles of next generation sequencing, RNA-seq and microarray
Basic principles of animal models
A basic physics knowledge about atoms and nuclear decays
Multiple Choice Test Questions
Pathology
Programma
The pathology lab: a platform for patients' diagnosis and therapy
Technologies and methods for assessing predictive factors in cancer patients.
Molecular follow-up of tumor resistance: the liquid biopsy model.
Pathology in the multidisciplinary team: from morphology to genome.
Materiale didattico e bibliografia
Students will receive pdf files of the presentations used during the lectures.
Moreover review articles will be available on the different topics.
Radiology
Programma
Optical Imaging: Principles, methods and relevant procedures; pre-clinical applications
RX/CT and Ultrasound: Principles and methods for ultrasound imaging; clinical and pre-clinical applications
Magnetic Resonance Imaging (MRI): methodology, and advanced applications
Nuclear based techniques: Principles and methods of single photon emission tomography (SPECT),
positron emission tomography (PET) imaging procedures.
Materiale didattico e bibliografia
Students will receive pdf files of the presentations used during the lectures.
Moreover review articles will be available on the different topics.
Blood diseases
Programma
Clonal heterogeneity in blood cancers by NGS
Novel classifications and their biological and prognostic relevance in hematological tumors
based on NGs study
Use of murine models for the study of mutations affecting splicing factors in the pathogenesis
of myeloid disorders.
Monitoring the minimal residual disease in hematological neoplasms:
technical advances and clinical implications
Non coding RNA in blood cancers: from genetic associations, molecular mechanisms, and therapeutic strategies
Materiale didattico e bibliografia
Students will receive pdf files of the presentations used during the lectures.
Moreover review articles will be available on the different topics.
Molecular biology
Programma
Patient-specific tumor models: from xenografts to organoids.
Cancer reprogramming: from mechanism to tool for the dissection of tumor pathogenesis
and the identification of draggable pathways
Cancer-specific epigenetic dysregulation and its therapeutic application.
Materiale didattico e bibliografia
Students will receive pdf files of the presentations used during the lectures.
Moreover review articles will be available on the different topics.
Moduli o unità didattiche
Blood diseases
MED/15 - MALATTIE DEL SANGUE - CFU: 2
Lezioni: 14 ore

Molecular biology
BIO/11 - BIOLOGIA MOLECOLARE - CFU: 2
Lezioni: 14 ore
Docente: Testa Giuseppe

Pathology
MED/08 - ANATOMIA PATOLOGICA - CFU: 1
Lezioni: 7 ore

Radiology
MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA - CFU: 1
Lezioni: 7 ore
Docente: Ottobrini Luisa

Docente/i
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